Michal Tomasz Marzec
Associate Professor
Molecular Cardiology and Membrane Proteins
Blegdamsvej 3, 2200 København N, 12.6, Building: 08
Date of birth: June 2, 1973, Wroclaw, Poland, married, two children
Education:
2011 Ph.D. Medical University of Bialystok, advisor prof. R. Bucki
2000 M.D. Medical University of Warsaw
Research Experience:
- 2019: Associate Professor, Department of Biomedical Sciences, University of Copenhagen
- 2015-2018: Assistant Professor, Department of Biomedical Sciences, University of Copenhagen
- 2010-2014: Research Associate II, Cell and Molecular Biology, Abramson Pediatric Research Center, Children’s Hospital of Philadelphia, USA
- 2006-2009:Research Associate, Cancer Biology, University of Pennsylvania, USA
- 2001-2006: Visiting Scholar, Cancer Biology, University of Pennsylvania, USA
Grants (Principal Investigator):
2018 Augustinus Fonden
2018 Private Foundations for purchase of lab equipment (OMIX application)
2018 DFF FTP Project 1 (Prof. Gourdon PI)
2017 ERC Starting grant 2nd round, not founded
2017-2018 EFSD/Lilly Programme
2017 Vissing Fonden
2017 Bjarne Jensen Fonden
2017 Poul og Erna Sehested Hansens Fond
2017 Eva og Hans Carl Holms Mindelegat
2016-2017 Kirsten og Freddy Johansens Fond
2016 A.P. Møller Fond
2016 Dagmar Marshall Fond
2015-2016 Augustinus Fonden
2015-2017 DFF Marie Curie Mobilex
2011-2016 National Institute on Aging, NIH
2011-2013 CTRC Junior Investigator Pilot Grant Program University of Pennsylvania and Children’s Hospital of Philadelphia
Biometrics:
H-index: 21 (Google scholar, Scopus)
i10-index: 24 (Google scholar)
Citations: 1950 (Google scholar), 1430 (Scopus)
Research Publications, peer reviewed: 30, 1 as a senior author, 13 as the first author
Teaching and Supervision
At UCPH:
- Male and female reproductive systems for non-medical students. Lectures during 2018.
- Sygdomslære for ikke-klinikere, Sundhed og Informatik, Kvantitativ biologi og sygdomsmodellering courses since 2017.
- Kursus i medicinsk fysiologi og patofysiologi Odontology since 2018.
- The main supervisor for PhD, six Master students (UCPH), one ERASMUS Master student and four BA students (UCPH, U. of California and U. of Michigan, USA)
At USA:
- I have daily supervised Master students as well as trained technicians
Pedagogical competences
Universitetspædagogikum (Higher Education) course 2017 at UCPH
Postdoctoral Research Leadership Course, May 2015 at Copenhagen Business School
Laboratory Animal Science Course, March 2015 at UCPH
Collaborations:
Prof. Marie-Pierre Bousquet, Toulouse, France
Prof. Peter Arvan U. of Michigan, USA
Prof. Anders Tengholm Uppsala University, Sweden
Prof. Sebastian Barg Uppsala University, Sweden
Prof. J. V. Rocheleau U. of Toronto, Canada
Prof. Bu Yeap U. of Western Australia, Australia
Prof. Pontus E. Gourdon UCPH, Denmark
Prof. Per A. Pedersen UCPH, Denmark
Prof. Soren Buus UCPH, Denmark
Prof. Flemming Pociot Herlev-Gentofte Hospital, Denmark
Meetings organizing:
- 2017 BioFrontiers Summit, University of Copenhagen
- 2016 “Single pancreatic islet transduction using HEAT-on-Chip device” Workshop. University of Copenhagen
Invited Lectures:
- 2018; 'Proinsulin processing and endoplasmic reticulum chaperones' Islet Study Group meeting, Potchdam 2018
- 2018: “How do proinsulin peptides become immunogenic“ EFSD, Lilly, Research grant program, Dresden, Germany
- 2013: “Variations in GRP94 gene in human centenarians’ populations” Gordon Research Conference Insulin-Like Growth Factors in Physiology & Disease; Ventura CA
- 2012: “Regulation of IGF-1 by Human GRP94” National Institute on Aging, NIH Bethesda Sixth Annual Division of Aging Biology New Investigators Forum
- 2009: “NPM/ALK mimics IL-2 type signaling in CD4+ T cells” University of Pennsylvania, Philadelphia, PA November 2009
Awards:
2013 IGF Society Award
2006 Medical University of Warsaw President’s award for research on B cell lymphomas
Professional Services:
Reviewer for Polish Ministry of Science and Higher Education
Reviewer for the journal of Blood, Laboratory Investigation, Leukemia, Oncogene
Memberships in Professional and Scientific Societies:
2016 Danish Society for Immunology
2016 European Association for the Study of Diabetes
2014 Danish Diabetes Academy
2013 Penn/CHOP Center for Orphan Disease Research and Therapy
2013 International Society for IGF Research
2005 American Society of Cell Biology
2000 The Polish Chamber of Physicians and Dentists
Symposia and Abstracts (2012-2018):
- October, 2017: “The role of GRP94 chaperone in proinsulin processing“ NovoNordisk Conference, Denmark
- May, 2017: “The role of GRP94 chaperone in proinsulin processing“ Beta Cell Workshop, Dresden, Germany
- May, 2016: “The role of GRP94 chaperone in proinsulin processing“ EASD 52nd Annual meeting, Munch, Germany
- May, 2015: “GRP94 as a regulator of insulin and IGF production“ The EASD Study Group on Genetics of Diabetes Krakow, Poland
- Nov, 2013: “Modulation of maturation and secretion of IGF-1 and -2 by genetic variants of GRP94 found in human populations” Copenhagen, Denmark “Genomics in Metabolism” 4th Copenhagen Bioscience Conference
- July, 2012: “Hypomorphic variants of human GRP94 affect the production of circulating IGF-1” Bregenz, Austria The 11th International Symposium on Neurobiology and Neuroendocrinology of Aging
- Feb, 2012: “IGF and human GRP94” GRC meeting Biology of Aging; Ventura CA
Publications:
- S.M. Ghiasi, T. Dahlby, C.H. Andersen, L. Haataja, S. Pedersen, M.O. Hmeadi, M. Yang, C. Pihl, S. Bresson, M. Khilji, K. Klindt, O. Cheta, M. J. Perone, B.Tyrberg, C. Prats, S. Barg, A. Tengholm, P. Arvan, T. Mandrup-Poulsen, M. Marzec. The role of GRP94 chaperone in proinsulin handling. Diabetes 2019, in press. IF: 8.6
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M. Marzec Students’ supervision and introduction during the initial period in the research laboratory: does it matter? Improving university Science Teaching and Learnig, Vol. 12 p. 107 2018
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M. Wątek, B. Durnaś, T. Wollny, M. Pasiarski, S. Góźdź, M. Marzec, A. Chabowska, P. Wolak, M. Żendzian-Piotrowska, R.Bucki. Unexpected profile of sphingolipid contents in blood and bone marrow plasma collected from patients diagnosed with acute myeloid leukemia. Lipids in Health and Disease. 16:235 2017 IF: 2
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M. Marzec, CP. Hawkes, D. Eletto, S. Boyle, R. Rosenfeld and V. Hwa, J-M. Wit, H A. van Duyvenvoorde, W. Oostdijk, M. Losekoot, LuCamp, BB. Yeap, L. Flicker, G. Atzmon, N. Barzilai, A. Grimberg, Y. Argon. A human variant of GRP94 that supports IGF production inefficiently. Endocrinology 2016. IF: 4.3
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Durnaś B, Wątek M, Wollny T, Niemirowicz K, Marzec M, Bucki R, Góźdź S. "Utility of blood procalcitonin concentration in the management of cancer patients with infections" OncoTargets and Therapy, Dec 2015. IF: 2.3
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Urszula Surel, Katarzyna Niemirowicz, Marzec M, Paul B. Savage and Robert Bucki. 2014 Ceragenins – a new promise to fight multidrug resistant bacterial infections. Studia Medyczne UJK 30 (3): 207–213 Review
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Marzec M, Liu X, Halasa K, Zhang Q, Odum N, Wasik MA. 2013. Malignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogramming. J.of Immunology Vol.191 (12) p.6200-7. IF: 4.9
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Lee SC, Marzec M, Liu X, Wehrli S, Kantekure K, Ragunath PN, Nelson DS, Delikatny EJ, Glickson JD, Wasik MA. 2013. Decreased lactate concentration and glycolytic enzyme expression reflect inhibition of mTOR signal transduction pathway in B-cell lymphoma. NMR Biomed. Vol.26 p.106-14 IF: 3
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Marzec M, Eletto D, Argon Y. 2012. GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum. Biochim Biophys Acta. Vol. 1823(3) p.774-787. IF: 4.9 Cited: 175
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Lee SC, Arias-Mendoza F, Poptani H, Delikatny EJ, Wasik M, Marzec M, Schuster SJ, Nasta SD, Svoboda J, O'Connor OA, Smith MR, Glickson JD. 2012. Prediction and Early Detection of Response by NMR Spectroscopy and Imaging. PET Clin. Vol.7 p.119-26 IF: 1
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Marzec M, Liu X, Wysocka M, Rook AH, Odum N, Wasik MA. 2011. Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells. PloS One. Vol. 6(9) e.24849 IF: 2.8
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Marzec M, Xiaobin Liu, Waihay Wong, Yusong Yang, Theresa Pasha, Kanchan Kantekure, Paul Zhang, Anders Woetmann, Mangeng Cheng, Niels Odum, and Mariusz A. Wasik. 2011. Oncogenic kinase NPM/ALK induces through STAT3 expression of HIF1a. Oncogene. Vol. 30(11) p. 1372-8 IF: 8.4
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Robert Bucki, Alina Kułakowska, Fitzroy J. Byfield, Małgorzata Żendzian-Piotrowska, Marcin Baranowski, M. Marzec, Jessamine P. Winer, Nicholas J. Ciccarelli, Jan Górski, Wiesław Drozdowski, Robert Bittman and Paul A. Janmey. 2010. Plasma gelsolin modulates cellular response to sphingosine 1-phosphate Am J Physiol Cell Physiology. Vol.299 p.1516-23 IF: 2.3
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M El-Salem, PN Raghunath, M Marzec, M Kasprzycka, X Liu, M A Wasik. 2009. Activation of mTORC1 signaling pathway in AIDS-related lymphomas (ARL). American Journal of Pathology. Vol.175 p.817-24 IF: 4.2
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MA Wasik, Q Zhang, M Marzec, M Kasprzycka, HY Wang, X Liu. 2009. Anaplastic lymphoma kinase (ALK)-induced malignancies: novel mechanisms of cell transformation and potential therapeutic approaches. Sem. Oncology. Vol.36 p.27-35 IF: 6.2
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Marzec M, Zhang Q, Goradia A, Raghunath PN, Liu X, Paessler M, Wang HY, Wysocka M, Cheng M, Ruggeri BA, Wasik MA. 2008. Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1). Proc Natl Acad Sci U S A. Vol. 105(52) p.20852-7 IF: 9.6 Cited: 344
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Kasprzycka M, Zhang Q, Witkiewicz A, Marzec M, Potoczek M, Liu X, Wang HY, Milone M, Basu S, Mauger J, Choi JK, Abrams JT, Hou JS, Rook AH, Vonderheid E, Woetmann A, Odum N, Wasik MA. 2008. Gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes. J Immunology. Vol. 181 p.2506-12 IF: 4.9
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Marzec M, K Halasa, M Kasprzycka, JS Yoon, X Liu, JW Tobias, D Baldwin, Q Zhang, N Odum, AH Rook, MA Wasik. 2008. Differential effects of IL-2 and IL-15 vs. IL-21 on malignant CD4+ T lymphocytes. Cancer Research Vol. 68 p.1083-91 IF: 9.3
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Marzec M, Xiaobin Liu, M. Kasprzycka, A. Witkiewicz, Puthiaveetil Raghunath, Mouna El-Salem, Erle Robertson, Niels Odum, Mariusz A. Wasik 2008. IL-2- and IL-15-induced activation of the rapamycin-sensitive mTORC1 pathway in malignant CD4+ T lymphocytes. Blood. Vol. 111 p.2181-9 IF: 13.1
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Marzec M, M Kasprzycka, X Liu, M El-Salem, K Halasa, PN Raghunath, R Bucki, P Wlodarski, MA Wasik. 2007. Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway. Oncogene. Vol. 26 p. 5606-14 IF: 8.4
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P Wlodarski, X Liu, Q Zhang, M Kasprzycka, M Marzec, and M A Wasik. 2007. PU.1 regulates transcription of SHP-1 in hematopoietic cells. JBC. Vol. 282 p.6316-23 IF: 4.1
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M El-Salem, PN Raghunath, M Marzec, P Wlodarski, E Hsi, MA Wasik. 2007. Constitutive activation of mTOR signaling pathway in post-transplant lymphoproliferative disorders (PTLDs). Lab Investigation.Vol.87 p.29-39 IF: 4.8
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S-H Jo, C Yang, Q Miao, M Marzec, MA Wasik, P Lu, YL Wang. 2006. PPARg promotes lymphocyte survival through its actions on cellular metabolic activities. J Immunology. Vol.177 p.3737-45 IF: 4.9
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Marzec M, Monika Kasprzycka, Xiaobin Liu, Raghunath PN, Pawel Wlodarski, Mariusz A. Wasik. 2006. Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf. Oncogene. Vol. 26 p.813-21 IF: 8.4
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Kasprzycka M, Marzec M, Liu X, Zhang Q, Wasik MA. 2006. Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3. 2006. Proc Natl Acad Sci U S A. Vol. 103 p.9964-9 IF: 9.6 Cited: 135
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Marzec M, Monika Kasprzycka, Raymond Lai, Andrew Gladden, Pawel Wlodarski, Ewa Tomczak, Peter Nowell, Samuel E. DePrimo, Seth Sadis, Stephen Eck, Stephen J. Schuster, J. Alan Diehl, Mariusz A. Wasik. 2006. Mantle cell lymphoma cells express predominantly Cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity. Blood. Vol. 108 p.1744-50 IF: 13.1 Cited: 118
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Kasprzycka M, Majewski M, Wang ZJ, Ptasznik A, Wysocka M, Zhang Q, Marzec M, Gimotty P, Crompton MR, Wasik MA. 2006. Expression and Oncogenic Role of Brk (PTK6/Sik) Protein Tyrosine Kinase in Lymphocytes. Am J Pathology. Vol. 168 p.1631-41 IF: 4.2
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Nagasawa T, Zhang Q, Raghunath PN, Wong HY, El-Salem M, Szallasi A, Marzec M, Gimotty P, Rook AH, Vonderheid EC, Odum N, Wasik MA. 2005. Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells; delayed expression of the p16 protein upon reversal of the silencing. Leukemia Res. Vol. 30 p.303-12 2.3
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Marzec M, Kasprzycka M, Ptasznik A, Wlodarski P, Zhang Q, Odum N, Wasik MA. 2005. Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3. Lab Investigation. Vol. 85 p.1544-54 IF: 4.8
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Wlodarski P, Kasprzycka M, Liu X, Marzec M, Robertson ES, Slupianek A, Wasik MA. 2005. Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase, insulin growth factor-I, and serum. Cancer Research. Vol. 65 p. 7800-8 IF: 9.3
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Zhang Q, Wang HY, Marzec M, Raghunath PN, Nagasawa T, Wasik MA. 2005. STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes. Proc Natl Acad Sci U S A. Vol. 102 p. 6948-53 IF: 9.6 Cited: 204
Education
M.D.; Ph.D.
ID: 129941679
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Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells
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