Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes
Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
Standard
Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes. / Christensen, M; Sparre-Ulrich, A H; Hartmann, B; Grevstad, U; Rosenkilde, M M; Holst, J J; Vilsbøll, T; Knop, F K.
I: International journal of obesity (2005), Bind 39, Nr. 11, 11.2015, s. 1651-1654.Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes
AU - Christensen, M
AU - Sparre-Ulrich, A H
AU - Hartmann, B
AU - Grevstad, U
AU - Rosenkilde, M M
AU - Holst, J J
AU - Vilsbøll, T
AU - Knop, F K
PY - 2015/11
Y1 - 2015/11
N2 - Treatment with liraglutide leads to weight loss. We investigated whether blood-to-cerebrospinal fluid (CSF) transfer of liraglutide occurs, and if so, whether it associates with clinical weight loss following liraglutide treatment in humans. We performed lumbar puncture and blood sampling in eight patients with type 2 diabetes (mean (range)): age 63 (54-79) years; actual body weight: 90 (75-118) kg treated with 1.8 mg liraglutide for 14 (5-22) months and with a treatment-induced weight loss of 8.4 (7-11) kg. We measured liraglutide in plasma and CSF with a radioimmunoassay specific for the N-terminus of the GLP-1 moiety of liraglutide. Mean plasma liraglutide was 31 (range: 21-63) nmol l(-1). The mean CSF-liraglutide concentration was 6.5 (range: 0.9-13.9) pmol l(-1). Ratio of CSF: plasma-liraglutide concentrations was 0.02 (range: 0.07-0.002)% and plasma liraglutide did not correlate with CSF-liraglutide levels (P=0.67). Body weight loss tended to correlate with plasma-liraglutide levels (P=0.06), but not with CSF-liraglutide levels (P=0.69). In conclusion, we measured very low concentrations of liraglutide in CSF, and the levels of CSF liraglutide did not correlate with the actual clinical weight loss in these patients. The amount of liraglutide in plasma tended to correlate with the clinical weight loss.
AB - Treatment with liraglutide leads to weight loss. We investigated whether blood-to-cerebrospinal fluid (CSF) transfer of liraglutide occurs, and if so, whether it associates with clinical weight loss following liraglutide treatment in humans. We performed lumbar puncture and blood sampling in eight patients with type 2 diabetes (mean (range)): age 63 (54-79) years; actual body weight: 90 (75-118) kg treated with 1.8 mg liraglutide for 14 (5-22) months and with a treatment-induced weight loss of 8.4 (7-11) kg. We measured liraglutide in plasma and CSF with a radioimmunoassay specific for the N-terminus of the GLP-1 moiety of liraglutide. Mean plasma liraglutide was 31 (range: 21-63) nmol l(-1). The mean CSF-liraglutide concentration was 6.5 (range: 0.9-13.9) pmol l(-1). Ratio of CSF: plasma-liraglutide concentrations was 0.02 (range: 0.07-0.002)% and plasma liraglutide did not correlate with CSF-liraglutide levels (P=0.67). Body weight loss tended to correlate with plasma-liraglutide levels (P=0.06), but not with CSF-liraglutide levels (P=0.69). In conclusion, we measured very low concentrations of liraglutide in CSF, and the levels of CSF liraglutide did not correlate with the actual clinical weight loss in these patients. The amount of liraglutide in plasma tended to correlate with the clinical weight loss.
U2 - 10.1038/ijo.2015.136
DO - 10.1038/ijo.2015.136
M3 - Letter
C2 - 26228460
VL - 39
SP - 1651
EP - 1654
JO - International Journal of Obesity
JF - International Journal of Obesity
SN - 0307-0565
IS - 11
ER -
ID: 150708849