Total average diastolic longitudinal displacement by colour tissue doppler imaging as an assessment of diastolic function
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Total average diastolic longitudinal displacement by colour tissue doppler imaging as an assessment of diastolic function. / de Knegt, Martina Chantal; Biering-Sørensen, Tor; Søgaard, Peter; Sivertsen, Jacob; Jensen, Jan Skov; Møgelvang, Rasmus.
I: Cardiovascular Ultrasound, Bind 14, 41, 17.09.2016.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Total average diastolic longitudinal displacement by colour tissue doppler imaging as an assessment of diastolic function
AU - de Knegt, Martina Chantal
AU - Biering-Sørensen, Tor
AU - Søgaard, Peter
AU - Sivertsen, Jacob
AU - Jensen, Jan Skov
AU - Møgelvang, Rasmus
PY - 2016/9/17
Y1 - 2016/9/17
N2 - BACKGROUND: The current method for a non-invasive assessment of diastolic dysfunction is complex with the use of algorithms of many different echocardiographic parameters. Total average diastolic longitudinal displacement (LD), determined by colour tissue Doppler imaging (TDI) via the measurement of LD during early diastole and atrial contraction, can potentially be used as a simple and reliable alternative.METHODS: In 206 patients, using GE Healthcare Vivid E7 and 9 and Echopac BT11 software, we determined both diastolic LD, measured in the septal and lateral walls in the apical 4-chamber view by TDI, and the degree of diastolic dysfunction, based on current guidelines. Of these 206 patients, 157 had cardiac anomalies that could potentially affect diastolic LD such as severe systolic heart failure (n = 45), LV hypertrophy (n = 49), left ventricular (LV) dilation (n = 30), and mitral regurgitation (n = 33). Intra and interobserver variability of diastolic LD measures was tested in 125 patients.RESULTS: A linear relationship between total average diastolic LD and the degree of diastolic dysfunction was found. A total average diastolic LD of 10 mm was found to be a consistent threshold for the general discrimination of patients with or without diastolic dysfunction. Using linear regression, total average diastolic LD was estimated to fall by 2.4 mm for every increase in graded severity of diastolic dysfunction (β = -0.61, p-value <0.001). Patients with LV hypertrophy had preserved total average diastolic LD despite being classified as having diastolic dysfunction. Reproducibility of LD measures was acceptable.CONCLUSIONS: There is strong evidence suggesting that patients with a total average diastolic LD under 10 mm have diastolic dysfunction.
AB - BACKGROUND: The current method for a non-invasive assessment of diastolic dysfunction is complex with the use of algorithms of many different echocardiographic parameters. Total average diastolic longitudinal displacement (LD), determined by colour tissue Doppler imaging (TDI) via the measurement of LD during early diastole and atrial contraction, can potentially be used as a simple and reliable alternative.METHODS: In 206 patients, using GE Healthcare Vivid E7 and 9 and Echopac BT11 software, we determined both diastolic LD, measured in the septal and lateral walls in the apical 4-chamber view by TDI, and the degree of diastolic dysfunction, based on current guidelines. Of these 206 patients, 157 had cardiac anomalies that could potentially affect diastolic LD such as severe systolic heart failure (n = 45), LV hypertrophy (n = 49), left ventricular (LV) dilation (n = 30), and mitral regurgitation (n = 33). Intra and interobserver variability of diastolic LD measures was tested in 125 patients.RESULTS: A linear relationship between total average diastolic LD and the degree of diastolic dysfunction was found. A total average diastolic LD of 10 mm was found to be a consistent threshold for the general discrimination of patients with or without diastolic dysfunction. Using linear regression, total average diastolic LD was estimated to fall by 2.4 mm for every increase in graded severity of diastolic dysfunction (β = -0.61, p-value <0.001). Patients with LV hypertrophy had preserved total average diastolic LD despite being classified as having diastolic dysfunction. Reproducibility of LD measures was acceptable.CONCLUSIONS: There is strong evidence suggesting that patients with a total average diastolic LD under 10 mm have diastolic dysfunction.
KW - Aged
KW - Diastole
KW - Echocardiography, Doppler, Pulsed
KW - Female
KW - Heart Ventricles
KW - Humans
KW - Male
KW - Middle Aged
KW - Reproducibility of Results
KW - Ventricular Dysfunction, Left
KW - Ventricular Function, Left
U2 - 10.1186/s12947-016-0083-2
DO - 10.1186/s12947-016-0083-2
M3 - Journal article
C2 - 27639377
VL - 14
JO - Cardiovascular Ultrasound
JF - Cardiovascular Ultrasound
SN - 1476-7120
M1 - 41
ER -
ID: 176335951