Organism-wide, cell-type-specific secretome mapping of exercise training in mice
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Organism-wide, cell-type-specific secretome mapping of exercise training in mice. / Wei, Wei; Riley, Nicholas M.; Lyu, Xuchao; Shen, Xiaotao; Guo, Jing; Raun, Steffen H.; Zhao, Meng; Moya-Garzon, Maria Dolores; Basu, Himanish; Sheng-Hwa Tung, Alan; Li, Veronica L.; Huang, Wentao; Wiggenhorn, Amanda L.; Svensson, Katrin J.; Snyder, Michael P.; Bertozzi, Carolyn R.; Long, Jonathan Z.
I: Cell Metabolism, Bind 35, Nr. 7, e11, 2023, s. 1261-1279.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Organism-wide, cell-type-specific secretome mapping of exercise training in mice
AU - Wei, Wei
AU - Riley, Nicholas M.
AU - Lyu, Xuchao
AU - Shen, Xiaotao
AU - Guo, Jing
AU - Raun, Steffen H.
AU - Zhao, Meng
AU - Moya-Garzon, Maria Dolores
AU - Basu, Himanish
AU - Sheng-Hwa Tung, Alan
AU - Li, Veronica L.
AU - Huang, Wentao
AU - Wiggenhorn, Amanda L.
AU - Svensson, Katrin J.
AU - Snyder, Michael P.
AU - Bertozzi, Carolyn R.
AU - Long, Jonathan Z.
N1 - Publisher Copyright: © 2023 Elsevier Inc.
PY - 2023
Y1 - 2023
N2 - There is a significant interest in identifying blood-borne factors that mediate tissue crosstalk and function as molecular effectors of physical activity. Although past studies have focused on an individual molecule or cell type, the organism-wide secretome response to physical activity has not been evaluated. Here, we use a cell-type-specific proteomic approach to generate a 21-cell-type, 10-tissue map of exercise training-regulated secretomes in mice. Our dataset identifies >200 exercise training-regulated cell-type-secreted protein pairs, the majority of which have not been previously reported. Pdgfra-cre-labeled secretomes were the most responsive to exercise training. Finally, we show anti-obesity, anti-diabetic, and exercise performance-enhancing activities for proteoforms of intracellular carboxylesterases whose secretion from the liver is induced by exercise training.
AB - There is a significant interest in identifying blood-borne factors that mediate tissue crosstalk and function as molecular effectors of physical activity. Although past studies have focused on an individual molecule or cell type, the organism-wide secretome response to physical activity has not been evaluated. Here, we use a cell-type-specific proteomic approach to generate a 21-cell-type, 10-tissue map of exercise training-regulated secretomes in mice. Our dataset identifies >200 exercise training-regulated cell-type-secreted protein pairs, the majority of which have not been previously reported. Pdgfra-cre-labeled secretomes were the most responsive to exercise training. Finally, we show anti-obesity, anti-diabetic, and exercise performance-enhancing activities for proteoforms of intracellular carboxylesterases whose secretion from the liver is induced by exercise training.
KW - cell type
KW - CES2
KW - energy metabolism
KW - exercise
KW - exercise performance
KW - hepatokine
KW - obesity
KW - secretome
KW - tissue crosstalk
U2 - 10.1016/j.cmet.2023.04.011
DO - 10.1016/j.cmet.2023.04.011
M3 - Journal article
C2 - 37141889
AN - SCOPUS:85163155389
VL - 35
SP - 1261
EP - 1279
JO - Cell Metabolism
JF - Cell Metabolism
SN - 1550-4131
IS - 7
M1 - e11
ER -
ID: 358968199