Neural synchronization via potassium signaling
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Neural synchronization via potassium signaling. / Postnov, Dmitry E; Ryazanova, Ludmila S; Mosekilde, Erik; Sosnovtseva, Olga.
I: International Journal of Neural Systems, Bind 16, Nr. 2, 01.04.2006, s. 99-109.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Neural synchronization via potassium signaling
AU - Postnov, Dmitry E
AU - Ryazanova, Ludmila S
AU - Mosekilde, Erik
AU - Sosnovtseva, Olga
PY - 2006/4/1
Y1 - 2006/4/1
N2 - Using a relatively simple model we examine how variations of the extracellular potassium concentration can give rise to synchronization of two nearby pacemaker cells. With the volume of the extracellular space and the rate of potassium diffusion as control parameters, the dual nature of this resource-mediated coupling is found to be responsible for the coexistence of competing patterns of in- and anti-phase synchronization between identical cells. Cell heterogeneity produces significant modifications of the dynamical regimes in the control parameter plane. By comparison with conventional gap junctional coupling, potassium signaling gives rise to considerable changes of the cellular response to external stimuli.
AB - Using a relatively simple model we examine how variations of the extracellular potassium concentration can give rise to synchronization of two nearby pacemaker cells. With the volume of the extracellular space and the rate of potassium diffusion as control parameters, the dual nature of this resource-mediated coupling is found to be responsible for the coexistence of competing patterns of in- and anti-phase synchronization between identical cells. Cell heterogeneity produces significant modifications of the dynamical regimes in the control parameter plane. By comparison with conventional gap junctional coupling, potassium signaling gives rise to considerable changes of the cellular response to external stimuli.
KW - Animals
KW - Biological Clocks
KW - Gap Junctions
KW - Humans
KW - Models, Neurological
KW - Nerve Net
KW - Neural Pathways
KW - Neuroglia
KW - Neurons
KW - Periodicity
KW - Potassium Channels
KW - Signal Transduction
M3 - Journal article
C2 - 16688850
VL - 16
SP - 99
EP - 109
JO - International Journal of Neural Systems
JF - International Journal of Neural Systems
SN - 0129-0657
IS - 2
ER -
ID: 33812643