Molecular Insights From Multiomics Studies of Physical Activity
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Molecular Insights From Multiomics Studies of Physical Activity. / Wei, Wei; Raun, Steffen H.; Long, Jonathan Z.
I: Diabetes, Bind 73, Nr. 2, 01.02.2024, s. 162-168.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Molecular Insights From Multiomics Studies of Physical Activity
AU - Wei, Wei
AU - Raun, Steffen H.
AU - Long, Jonathan Z.
N1 - Publisher Copyright: © 2024 by the American Diabetes Association.
PY - 2024/2/1
Y1 - 2024/2/1
N2 - Physical activity confers systemic health benefits and provides powerful protection against disease. There has been tremendous interest in understanding the molecular effectors of exercise that mediate these physiologic effects. The modern growth of multiomics technologies-including metabolomics, proteomics, phosphoproteomics, lipidomics, single-cell RNA sequencing, and epigenomics-has provided unparalleled opportunities to systematically investigate the molecular changes associated with physical activity on an organism-wide scale. Here, we discuss how multiomics technologies provide new insights into the systemic effects of physical activity, including the integrative responses across organs as well as the molecules and mechanisms mediating tissue communication during exercise. We also highlight critical unanswered questions that can now be addressed using these high-dimensional tools and provide perspectives on fertile future research directions.
AB - Physical activity confers systemic health benefits and provides powerful protection against disease. There has been tremendous interest in understanding the molecular effectors of exercise that mediate these physiologic effects. The modern growth of multiomics technologies-including metabolomics, proteomics, phosphoproteomics, lipidomics, single-cell RNA sequencing, and epigenomics-has provided unparalleled opportunities to systematically investigate the molecular changes associated with physical activity on an organism-wide scale. Here, we discuss how multiomics technologies provide new insights into the systemic effects of physical activity, including the integrative responses across organs as well as the molecules and mechanisms mediating tissue communication during exercise. We also highlight critical unanswered questions that can now be addressed using these high-dimensional tools and provide perspectives on fertile future research directions.
U2 - 10.2337/dbi23-0004
DO - 10.2337/dbi23-0004
M3 - Journal article
C2 - 38241506
AN - SCOPUS:85182850690
VL - 73
SP - 162
EP - 168
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 2
ER -
ID: 381502970