Modulation of KCNQ4 channel activity by changes in cell volume.
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Modulation of KCNQ4 channel activity by changes in cell volume. / Hougaard, Charlotte; Klaerke, Dan A; Hoffmann, Else K; Olesen, Søren-Peter; Jorgensen, Nanna K.
I: BBA General Subjects, Bind 1660, Nr. 1-2, 2004, s. 1-6.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Modulation of KCNQ4 channel activity by changes in cell volume.
AU - Hougaard, Charlotte
AU - Klaerke, Dan A
AU - Hoffmann, Else K
AU - Olesen, Søren-Peter
AU - Jorgensen, Nanna K
N1 - Keywords: Calcium; Carbamates; Cell Line; Cell Size; Cyclic AMP-Dependent Protein Kinases; Humans; Indoles; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Osmolar Concentration; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinase C; Pyridines; Signal Transduction
PY - 2004
Y1 - 2004
N2 - KCNQ4 channels expressed in HEK 293 cells are sensitive to cell volume changes, being activated by swelling and inhibited by shrinkage, respectively. The KCNQ4 channels contribute significantly to the regulatory volume decrease (RVD) process following cell swelling. Under isoosmotic conditions, the KCNQ4 channel activity is modulated by protein kinases A and C, G protein activation, and a reduction in the intracellular Ca2+ concentration, but these signalling pathways are not responsible for the increased channel activity during cell swelling.
AB - KCNQ4 channels expressed in HEK 293 cells are sensitive to cell volume changes, being activated by swelling and inhibited by shrinkage, respectively. The KCNQ4 channels contribute significantly to the regulatory volume decrease (RVD) process following cell swelling. Under isoosmotic conditions, the KCNQ4 channel activity is modulated by protein kinases A and C, G protein activation, and a reduction in the intracellular Ca2+ concentration, but these signalling pathways are not responsible for the increased channel activity during cell swelling.
U2 - 10.1016/j.bbamem.2003.11.015
DO - 10.1016/j.bbamem.2003.11.015
M3 - Journal article
C2 - 14757214
VL - 1660
SP - 1
EP - 6
JO - B B A - General Subjects
JF - B B A - General Subjects
SN - 0304-4165
IS - 1-2
ER -
ID: 6768730