HER4 and its cytoplasmic isoforms are associated with progression-free survival of malignant melanoma

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Standard

HER4 and its cytoplasmic isoforms are associated with progression-free survival of malignant melanoma. / Nielsen, Trine O; Poulsen, Steen Seier; Journe, Fabrice; Ghanem, Ghanem; Sorensen, Boe S.

I: Melanoma Research, Bind 24, Nr. 1, 02.2014, s. 88-91.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning

Harvard

Nielsen, TO, Poulsen, SS, Journe, F, Ghanem, G & Sorensen, BS 2014, 'HER4 and its cytoplasmic isoforms are associated with progression-free survival of malignant melanoma', Melanoma Research, bind 24, nr. 1, s. 88-91. https://doi.org/10.1097/CMR.0000000000000040

APA

Nielsen, T. O., Poulsen, S. S., Journe, F., Ghanem, G., & Sorensen, B. S. (2014). HER4 and its cytoplasmic isoforms are associated with progression-free survival of malignant melanoma. Melanoma Research, 24(1), 88-91. https://doi.org/10.1097/CMR.0000000000000040

Vancouver

Nielsen TO, Poulsen SS, Journe F, Ghanem G, Sorensen BS. HER4 and its cytoplasmic isoforms are associated with progression-free survival of malignant melanoma. Melanoma Research. 2014 feb.;24(1):88-91. https://doi.org/10.1097/CMR.0000000000000040

Author

Nielsen, Trine O ; Poulsen, Steen Seier ; Journe, Fabrice ; Ghanem, Ghanem ; Sorensen, Boe S. / HER4 and its cytoplasmic isoforms are associated with progression-free survival of malignant melanoma. I: Melanoma Research. 2014 ; Bind 24, Nr. 1. s. 88-91.

Bibtex

@article{a7624a1b41a54b9ba27504bda4fc3af4,
title = "HER4 and its cytoplasmic isoforms are associated with progression-free survival of malignant melanoma",
abstract = "HER4 belongs to the epidermal growth factor (EGF) family. Mutations in HER4 are associated with malignant melanoma. This points to HER4 as an important receptor in malignant melanoma and also raises the question of whether the other receptors in the EGF system could be involved. RT-qPCR mRNA quantification was carried out of all four EGF receptors (EGFR, HER2, HER3, and HER4) and the HER4 cytoplasmic isoforms in lymph node metastases from patients with malignant melanoma. We related their expression to progression of the disease. HER4 expression was found to be an indicator of short progression-free survival (P=0.0340). Interestingly, of the two cytoplasmic splice variants of HER4, the association of CYT1 (P=0.0176) with progression-free survival was more pronounced than that for CYT2 (P=0.0458). Also, HER3 was associated with progression-free survival (P=0.0169), whereas no association was found for EGFR or HER2 with time to progression. Our results further emphasize the role of HER4 as an important oncogene in malignant melanoma and point to HER4 as a possible drug target in this disease.",
author = "Nielsen, {Trine O} and Poulsen, {Steen Seier} and Fabrice Journe and Ghanem Ghanem and Sorensen, {Boe S}",
year = "2014",
month = feb,
doi = "10.1097/CMR.0000000000000040",
language = "English",
volume = "24",
pages = "88--91",
journal = "Melanoma Research",
issn = "0960-8931",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - HER4 and its cytoplasmic isoforms are associated with progression-free survival of malignant melanoma

AU - Nielsen, Trine O

AU - Poulsen, Steen Seier

AU - Journe, Fabrice

AU - Ghanem, Ghanem

AU - Sorensen, Boe S

PY - 2014/2

Y1 - 2014/2

N2 - HER4 belongs to the epidermal growth factor (EGF) family. Mutations in HER4 are associated with malignant melanoma. This points to HER4 as an important receptor in malignant melanoma and also raises the question of whether the other receptors in the EGF system could be involved. RT-qPCR mRNA quantification was carried out of all four EGF receptors (EGFR, HER2, HER3, and HER4) and the HER4 cytoplasmic isoforms in lymph node metastases from patients with malignant melanoma. We related their expression to progression of the disease. HER4 expression was found to be an indicator of short progression-free survival (P=0.0340). Interestingly, of the two cytoplasmic splice variants of HER4, the association of CYT1 (P=0.0176) with progression-free survival was more pronounced than that for CYT2 (P=0.0458). Also, HER3 was associated with progression-free survival (P=0.0169), whereas no association was found for EGFR or HER2 with time to progression. Our results further emphasize the role of HER4 as an important oncogene in malignant melanoma and point to HER4 as a possible drug target in this disease.

AB - HER4 belongs to the epidermal growth factor (EGF) family. Mutations in HER4 are associated with malignant melanoma. This points to HER4 as an important receptor in malignant melanoma and also raises the question of whether the other receptors in the EGF system could be involved. RT-qPCR mRNA quantification was carried out of all four EGF receptors (EGFR, HER2, HER3, and HER4) and the HER4 cytoplasmic isoforms in lymph node metastases from patients with malignant melanoma. We related their expression to progression of the disease. HER4 expression was found to be an indicator of short progression-free survival (P=0.0340). Interestingly, of the two cytoplasmic splice variants of HER4, the association of CYT1 (P=0.0176) with progression-free survival was more pronounced than that for CYT2 (P=0.0458). Also, HER3 was associated with progression-free survival (P=0.0169), whereas no association was found for EGFR or HER2 with time to progression. Our results further emphasize the role of HER4 as an important oncogene in malignant melanoma and point to HER4 as a possible drug target in this disease.

U2 - 10.1097/CMR.0000000000000040

DO - 10.1097/CMR.0000000000000040

M3 - Journal article

C2 - 24366194

VL - 24

SP - 88

EP - 91

JO - Melanoma Research

JF - Melanoma Research

SN - 0960-8931

IS - 1

ER -

ID: 93908081