Functional properties of Virus-Encoded and Virus-Regulated 7TM Receptors
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning
During co-evolution with their hosts, viruses have developed several survival strategies that involve exploitation of 7TM receptors. These include virus-encoded 7TM receptors and ligands and viral regulation of endogenous receptors. Many functional properties have been ascribed to virus-exploited 7TM receptors, and although the list of putative functions is steadily growing, the presence and/or utilization of 7TM receptors are still poorly understood for many of these. This review focuses on three well described functional properties: 1) the immune evasion strategies, exemplified by γ1-herpesvirus-encoded BILF1 receptors, the human cytomegalovirus (HCMV)-encoded US28 receptor and the Epstein-Barr virus (EBV)-regulated EBI2 (or GPR183), 2) the tissue tropism and virus-dissemination properties, exemplified by the murine CMV-encoded M33, and 3) the tumorigenic properties, exemplified by the human herpesvirus 8 (HHV8)-encoded ORF74, HCMV-US28 and EBV-BILF1. Given the general high “druggability” of 7TM receptors, and the recent progress in the understanding of in particular immune evasive functions of the virus-exploited 7TM receptors, we put a special emphasis on the progress of novel anti-viral therapeutic tools
Originalsprog | Engelsk |
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Titel | G Protein-Coupled Receptor Genetics : Research and Methods in the Post-Genomic Era |
Redaktører | Craig W. Stevens |
Antal sider | 20 |
Forlag | Humana Press |
Publikationsdato | 2014 |
Sider | 45-64 |
Kapitel | 3 |
ISBN (Trykt) | 978-1-62703-778-5 |
Status | Udgivet - 2014 |
Navn | Methods in Pharmacology and Toxicology |
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ISSN | 1557-2153 |
ID: 138866130