EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors

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Standard

EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors. / Nørregaard, Kristine; Benned-Jensen, Tau; Rosenkilde, Mette Marie.

I: Current Topics in Medicinal Chemistry, Bind 11, Nr. 6, 2011, s. 618-28.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nørregaard, K, Benned-Jensen, T & Rosenkilde, MM 2011, 'EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors', Current Topics in Medicinal Chemistry, bind 11, nr. 6, s. 618-28. https://doi.org/10.2174/1568026611109060618

APA

Nørregaard, K., Benned-Jensen, T., & Rosenkilde, M. M. (2011). EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors. Current Topics in Medicinal Chemistry, 11(6), 618-28. https://doi.org/10.2174/1568026611109060618

Vancouver

Nørregaard K, Benned-Jensen T, Rosenkilde MM. EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors. Current Topics in Medicinal Chemistry. 2011;11(6):618-28. https://doi.org/10.2174/1568026611109060618

Author

Nørregaard, Kristine ; Benned-Jensen, Tau ; Rosenkilde, Mette Marie. / EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors. I: Current Topics in Medicinal Chemistry. 2011 ; Bind 11, Nr. 6. s. 618-28.

Bibtex

@article{bd9e957b17cf4be5942b517a80398471,
title = "EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors",
abstract = "7TM receptors constitute one of the largest superfamilies of proteins in the human genome. They are involved in a large number of physiological and pathological processes in the human body and thus represent major and important drug targets for the pharmaceutical industry. Although the majority have been deorphanized, many remain orphan, and these orphan receptors constitute a large pool of potential drug targets. This review focuses on one of these orphan targets, the Epstein-Barr Virus-induced receptor 2, EBI2 (or GPR183), together with two structurally related receptors, GPR17 and GPR18. The pharmacology and {"}druggability{"} of these three receptors is reviewed through a thorough description of their structural and functional properties and in vivo biology together with a status of currently available ligands for these receptors.",
keywords = "Humans, Protein Conformation, Receptors, Cell Surface, Receptors, G-Protein-Coupled",
author = "Kristine N{\o}rregaard and Tau Benned-Jensen and Rosenkilde, {Mette Marie}",
year = "2011",
doi = "10.2174/1568026611109060618",
language = "English",
volume = "11",
pages = "618--28",
journal = "Current Topics in Medicinal Chemistry",
issn = "1568-0266",
publisher = "Bentham Science Publishers",
number = "6",

}

RIS

TY - JOUR

T1 - EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors

AU - Nørregaard, Kristine

AU - Benned-Jensen, Tau

AU - Rosenkilde, Mette Marie

PY - 2011

Y1 - 2011

N2 - 7TM receptors constitute one of the largest superfamilies of proteins in the human genome. They are involved in a large number of physiological and pathological processes in the human body and thus represent major and important drug targets for the pharmaceutical industry. Although the majority have been deorphanized, many remain orphan, and these orphan receptors constitute a large pool of potential drug targets. This review focuses on one of these orphan targets, the Epstein-Barr Virus-induced receptor 2, EBI2 (or GPR183), together with two structurally related receptors, GPR17 and GPR18. The pharmacology and "druggability" of these three receptors is reviewed through a thorough description of their structural and functional properties and in vivo biology together with a status of currently available ligands for these receptors.

AB - 7TM receptors constitute one of the largest superfamilies of proteins in the human genome. They are involved in a large number of physiological and pathological processes in the human body and thus represent major and important drug targets for the pharmaceutical industry. Although the majority have been deorphanized, many remain orphan, and these orphan receptors constitute a large pool of potential drug targets. This review focuses on one of these orphan targets, the Epstein-Barr Virus-induced receptor 2, EBI2 (or GPR183), together with two structurally related receptors, GPR17 and GPR18. The pharmacology and "druggability" of these three receptors is reviewed through a thorough description of their structural and functional properties and in vivo biology together with a status of currently available ligands for these receptors.

KW - Humans

KW - Protein Conformation

KW - Receptors, Cell Surface

KW - Receptors, G-Protein-Coupled

U2 - 10.2174/1568026611109060618

DO - 10.2174/1568026611109060618

M3 - Journal article

C2 - 21261596

VL - 11

SP - 618

EP - 628

JO - Current Topics in Medicinal Chemistry

JF - Current Topics in Medicinal Chemistry

SN - 1568-0266

IS - 6

ER -

ID: 48321193