Downregulation of Kv7.4 channel activity in primary and secondary hypertension
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Downregulation of Kv7.4 channel activity in primary and secondary hypertension. / Jepps, Thomas Andrew; Chadha, Preet S; Davis, Alison J; Harhun, Maksym I; Cockerill, Gillian W; Olesen, Søren Peter; Hansen, Rie S; Greenwood, Iain A.
I: Circulation, Bind 124, Nr. 5, 02.08.2011, s. 602-11.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Downregulation of Kv7.4 channel activity in primary and secondary hypertension
AU - Jepps, Thomas Andrew
AU - Chadha, Preet S
AU - Davis, Alison J
AU - Harhun, Maksym I
AU - Cockerill, Gillian W
AU - Olesen, Søren Peter
AU - Hansen, Rie S
AU - Greenwood, Iain A
PY - 2011/8/2
Y1 - 2011/8/2
N2 - Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators of vascular tone; however, nothing is known about the functional impact of these channels in vascular disease. We ascertained the effect of 3 structurally different activators of Kv7.2 through Kv7.5 channels (BMS-204352, S-1, and retigabine) on blood vessels from normotensive and hypertensive animals.
AB - Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators of vascular tone; however, nothing is known about the functional impact of these channels in vascular disease. We ascertained the effect of 3 structurally different activators of Kv7.2 through Kv7.5 channels (BMS-204352, S-1, and retigabine) on blood vessels from normotensive and hypertensive animals.
KW - Angiotensin II
KW - Animals
KW - Aorta, Thoracic
KW - Blood Pressure
KW - Carbamates
KW - Down-Regulation
KW - Hypertension
KW - Indoles
KW - KCNQ Potassium Channels
KW - Male
KW - Membrane Potentials
KW - Mesenteric Arteries
KW - Mice
KW - Phenylenediamines
KW - Rats
KW - Rats, Inbred SHR
KW - Rats, Wistar
KW - Vasoconstrictor Agents
U2 - 10.1161/CIRCULATIONAHA.111.032136
DO - 10.1161/CIRCULATIONAHA.111.032136
M3 - Journal article
C2 - 21747056
VL - 124
SP - 602
EP - 611
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 5
ER -
ID: 108539339