Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels
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Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels. / Larsen, A P; Bentzen, Bo Hjorth; Grunnet, M.
I: British Journal of Pharmacology, Bind 161, Nr. 3, 10.2010, s. 614-28.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels
AU - Larsen, A P
AU - Bentzen, Bo Hjorth
AU - Grunnet, M
PY - 2010/10
Y1 - 2010/10
N2 - K(v)11.1 channels are involved in regulating cellular excitability in various tissues including brain, heart and smooth muscle. In these tissues, at least two isoforms, K(v)11.1a and K(v)11.1b, with different kinetics, are expressed. K(v)11.1 activators are potential therapeutic agents, but their effects have only been tested on the K(v)11.1a isoform. In this study, the effects of two different K(v)11.1 activators, NS1643 and RPR260243, were characterized on K(v)11.1a and K(v)11.1b channels.
AB - K(v)11.1 channels are involved in regulating cellular excitability in various tissues including brain, heart and smooth muscle. In these tissues, at least two isoforms, K(v)11.1a and K(v)11.1b, with different kinetics, are expressed. K(v)11.1 activators are potential therapeutic agents, but their effects have only been tested on the K(v)11.1a isoform. In this study, the effects of two different K(v)11.1 activators, NS1643 and RPR260243, were characterized on K(v)11.1a and K(v)11.1b channels.
KW - Animals
KW - Cresols
KW - Ether-A-Go-Go Potassium Channels
KW - Membrane Potentials
KW - Oocytes
KW - Patch-Clamp Techniques
KW - Phenylurea Compounds
KW - Piperidines
KW - Protein Isoforms
KW - Quinolines
KW - Transfection
KW - Xenopus laevis
U2 - 10.1111/j.1476-5381.2010.00897.x
DO - 10.1111/j.1476-5381.2010.00897.x
M3 - Journal article
C2 - 20880400
VL - 161
SP - 614
EP - 628
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
SN - 0007-1188
IS - 3
ER -
ID: 45080993