Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor

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Standard

Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor. / Poulsen, Steen Seier; Nexø, Ebba.

I: Gut, Bind 25, Nr. 11, 11.1984, s. 1234-40.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Poulsen, SS & Nexø, E 1984, 'Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor', Gut, bind 25, nr. 11, s. 1234-40.

APA

Poulsen, S. S., & Nexø, E. (1984). Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor. Gut, 25(11), 1234-40.

Vancouver

Poulsen SS, Nexø E. Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor. Gut. 1984 nov.;25(11):1234-40.

Author

Poulsen, Steen Seier ; Nexø, Ebba. / Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor. I: Gut. 1984 ; Bind 25, Nr. 11. s. 1234-40.

Bibtex

@article{f25eea8d734f450f815065e4aaacfa8f,
title = "Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor",
abstract = "The present study was undertaken to investigate the effect of alpha- and beta-adrenergic agonists on secretion of epidermal growth factor (EGF) from the rat submandibular glands and to test the possibility of intestinal absorption of EGF. Alpha-adrenergic agonists increased the concentration of salivary EGF by approximately a hundred times, while the serum concentration of EGF was unchanged. The contents of EGF in the submandibular glands decreased upon administration of the alpha-adrenergic agonist noradrenaline, and this was confirmed on immunohistochemical investigation of the glands. Beta-adrenergic agonists had no effect on secretion of EGF from the submandibular glands. Intestinal absorption of EGF could not be confirmed, as stimulation by noradrenaline with free passage of saliva to the gastrointestinal tract and intrajejunal infusion of EGF had no influence on the concentration of EGF in serum. This study shows that alpha-adrenergic agonists stimulate exocrine secretion of submandibular EGF and that EGF in physiological amounts are not absorbed in the gastrointestinal tract.",
keywords = "Adrenergic alpha-Agonists, Adrenergic beta-Agonists, Animals, Epidermal Growth Factor, Intestinal Absorption, Male, Rats, Rats, Inbred Strains, Saliva, Stimulation, Chemical, Submandibular Gland",
author = "Poulsen, {Steen Seier} and Ebba Nex{\o}",
year = "1984",
month = nov,
language = "English",
volume = "25",
pages = "1234--40",
journal = "Gut",
issn = "0017-5749",
publisher = "B M J Group",
number = "11",

}

RIS

TY - JOUR

T1 - Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor

AU - Poulsen, Steen Seier

AU - Nexø, Ebba

PY - 1984/11

Y1 - 1984/11

N2 - The present study was undertaken to investigate the effect of alpha- and beta-adrenergic agonists on secretion of epidermal growth factor (EGF) from the rat submandibular glands and to test the possibility of intestinal absorption of EGF. Alpha-adrenergic agonists increased the concentration of salivary EGF by approximately a hundred times, while the serum concentration of EGF was unchanged. The contents of EGF in the submandibular glands decreased upon administration of the alpha-adrenergic agonist noradrenaline, and this was confirmed on immunohistochemical investigation of the glands. Beta-adrenergic agonists had no effect on secretion of EGF from the submandibular glands. Intestinal absorption of EGF could not be confirmed, as stimulation by noradrenaline with free passage of saliva to the gastrointestinal tract and intrajejunal infusion of EGF had no influence on the concentration of EGF in serum. This study shows that alpha-adrenergic agonists stimulate exocrine secretion of submandibular EGF and that EGF in physiological amounts are not absorbed in the gastrointestinal tract.

AB - The present study was undertaken to investigate the effect of alpha- and beta-adrenergic agonists on secretion of epidermal growth factor (EGF) from the rat submandibular glands and to test the possibility of intestinal absorption of EGF. Alpha-adrenergic agonists increased the concentration of salivary EGF by approximately a hundred times, while the serum concentration of EGF was unchanged. The contents of EGF in the submandibular glands decreased upon administration of the alpha-adrenergic agonist noradrenaline, and this was confirmed on immunohistochemical investigation of the glands. Beta-adrenergic agonists had no effect on secretion of EGF from the submandibular glands. Intestinal absorption of EGF could not be confirmed, as stimulation by noradrenaline with free passage of saliva to the gastrointestinal tract and intrajejunal infusion of EGF had no influence on the concentration of EGF in serum. This study shows that alpha-adrenergic agonists stimulate exocrine secretion of submandibular EGF and that EGF in physiological amounts are not absorbed in the gastrointestinal tract.

KW - Adrenergic alpha-Agonists

KW - Adrenergic beta-Agonists

KW - Animals

KW - Epidermal Growth Factor

KW - Intestinal Absorption

KW - Male

KW - Rats

KW - Rats, Inbred Strains

KW - Saliva

KW - Stimulation, Chemical

KW - Submandibular Gland

M3 - Journal article

C2 - 6149980

VL - 25

SP - 1234

EP - 1240

JO - Gut

JF - Gut

SN - 0017-5749

IS - 11

ER -

ID: 47489219