Olav Larsen
Postdoc
Molecular and Translational Pharmacology
Blegdamsvej 3B
2200 København N
- 2023
- Published
Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5
Larsen, Olav, Schuermans, S., Walser, Anna Louise Silvia, Louka, S., Lillethorup, I. A., Våbenø, J., Qvortrup, K., Proost, P. & Rosenkilde, Mette, 2023, In: FEBS Letters. 597, 24, p. 3049-3060Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPR162 is a beta cell CART receptor
Lindqvist, A., Abels, M., Shcherbina, L., Ngara, M., Kryvokhyzha, D., Chriett, S., Riva, M., Fajul, A., Barghouth, M., Luan, C., Eliasson, L., Larsen, Olav, Rosenkilde, Mette, Zhang, E., Renström, E. & Wierup, N., 2023, In: iScience. 26, 12, 15 p., 108416.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Identification of a conserved chemokine receptor motif that enables ligand discrimination
Larsen, Olav, van der Velden, W. J. C., Mavri, M., Schuermans, S., Rummel, P. C., Karlshøj, S., Gustavsson, Martin, Proost, P., Våbenø, J. & Rosenkilde, Mette, 2022, In: Science Signaling. 15, 724, eabg7042.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats
van der Velden, W. J. C., Smit, F. X., Christiansen, Charlotte Bayer, Møller, T. C., Hjortø, Gertrud Malene, Larsen, Olav, Schiellerup, S. P., Bräuner, Hans, Holst, Jens Juul, Hartmann, Bolette, Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: ACS Pharmacology & Translational Science. 4, 1, p. 296-313 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7
Jørgensen, Astrid Sissel, Larsen, Olav, Uetz-von Allmen, E., Lückmann, Michael, Legler, D. F., Frimurer, Thomas Michael, Veldkamp, C. T., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Frontiers in Immunology. 10, 14 p., 2156.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selective Allosteric Modulation of N-Terminally Cleaved, but Not Full Length CCL3 in CCR1
Larsen, Olav, Lückmann, Michael, van der Velden, W. J. C., Oliva-Santiago, M., Brvar, M., Ulven, Trond, Frimurer, Thomas Michael, Karlshøj, S. & Rosenkilde, Mette, 2019, In: ACS Pharmacology & Translational Science. 2, 6, p. 429-441 13 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Structure-function guided modeling of chemokine-GPCR specificity for the chemokine XCL1 and its receptor XCR1
Fox, J. C., Thomas, M. A., Dishman, A. F., Larsen, Olav, Nakayama, T., Yoshie, O., Rosenkilde, Mette & Volkman, B. F., 2019, In: Science Signaling. 12, 597, 15 p., eaat4128.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Mutational analysis of CCL20 reveals flexibility of N-terminal amino acid composition and length
Riutta, S. J., Larsen, Olav, Getschman, A. E., Rosenkilde, M. M., Hwang, S. T. & Volkman, B. F., Aug 2018, In: Journal of Leukocyte Biology. 104, 2, p. 423-434Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Larsen, Olav, Jepsen, Sara Lind, Balk-Møller, E., Andersen, Daniel Bjørklund, Deacon, Carolyn F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, Reidar, Hartmann, Bolette, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: Molecular Metabolism. 11, p. 84-95 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulin Secretion Depends on Intra-islet Glucagon Signaling
Svendsen, B., Larsen, Olav, Gabe, M. B. N., Christiansen, Charlotte Bayer, Rosenkilde, M. M., Drucker, D. J. & Holst, Jens Juul, 2018, In: Cell Reports. 25, 5, p. 1127-1134.E2Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity
Janssens, R., Boff, D., Ruytinx, P., Mortier, A., Vanheule, V., Larsen, Olav, Daugvilaite, V., Rosenkilde, Mette, Noppen, S., Liekens, S., Schols, D., De Meester, I., Opdenakker, G., Struyf, S., Teixeira, M. M., Amaral, F. A. & Proost, P., 2018, In: Frontiers in Immunology. 9, p. 1933Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy
Miles, T. F., Spiess, Katja, Jude, K. M., Tsutsumi, N., Burg, J. S., Ingram, J. R., Waghray, D., Hjortø, Gertrud Malene, Larsen, Olav, Ploegh, H. L., Rosenkilde, Mette & Garcia, K. C., 2018, In: eLife. 7, 23 p., e35850 .Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration
González-Motos, V., Jürgens, C., Ritter, B., Kropp, K. A., Durán, V., Larsen, Olav, Binz, A., Ouwendijk, W. J. D., Lenac Rovis, T., Jonjic, S., Verjans, G. M. G. M., Sodeik, B., Krey, T., Bauerfeind, R., Schulz, T. F., Kaufer, B. B., Kalinke, U., Proudfoot, A. E. I., Rosenkilde, Mette & Viejo-Borbolla, A., May 2017, In: PLOS Pathogens. 13, 5, 28 p., e1006346.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein engineering of the chemokine CCL20 prevents psoriasiform dermatitis in an IL-23-dependent murine model
Getschman, A. E., Imai, Y., Larsen, Olav, Peterson, F. C., Wu, X., Rosenkilde, M. M., Hwang, S. T. & Volkman, B. F., 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 47, p. 12460-12465 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Truncation of CXCL12 by CD26 reduces its CXC chemokine receptor 4- and atypical chemokine receptor 3-dependent activity on endothelial cells and lymphocytes
Janssens, R., Mortier, A., Boff, D., Ruytinx, P., Gouwy, M., Vantilt, B., Larsen, Olav, Daugvilaite, V., Rosenkilde, Mette, Parmentier, M., Noppen, S., Liekens, S., Van Damme, J., Struyf, S., Teixeira, M. M., Amaral, F. A. & Proost, P., 2017, In: Biochemical Pharmacology. 132, p. 92-101 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5)
Karlshøj, S., Amarandi, R. M., Larsen, Olav, Daugvilaite, V., Steen, A., Brvar, M., Pui, A., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 23 Dec 2016, In: Journal of Biological Chemistry. 291, 52, p. 26860-26874Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Attenuation of chemokine receptor function and surface expression as an immunomodulatory strategy employed by human cytomegalovirus is linked to vGPCR US28
Frank, T., Reichel, A., Larsen, Olav, Stilp, A., Rosenkilde, Mette, Stamminger, T., Ozawa, T. & Tschammer, N., 12 Dec 2016, In: Cell Communication and Signaling. 14, 16 p., 31.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines
Hjortø, Gertrud Malene, Larsen, Olav, Steen, A., Daugvilaite, V., Berg, Christian, Fares, S., Hansen, M., Ali, S. & Rosenkilde, Mette, 9 Dec 2016, In: Frontiers in Immunology. 7, 568.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119
Hassing, H. A., Fares, S., Larsen, Olav, Pad, H., Pedersen, M. H., Jones, R. M., Schwartz, Thue W., Hansen, Harald S. & Rosenkilde, Mette, 26 Aug 2016, In: Biochemical Pharmacology. 119, 1, p. 66-75 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding
Barington, L., Rummel, P. C., Lückmann, Michael, Pihl, H., Larsen, Olav, Daugvilaite, V., Johnsen, A. H., Frimurer, Thomas Michael, Karlshøj, S. & Rosenkilde, Mette, 19 May 2016, In: The Journal of Biological Chemistry. 291, 31, p. 16208-16220Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery and Characterization of Biased Allosteric Agonists of the Chemokine Receptor CXCR3
Milanos, L., Brox, R., Frank, T., Poklukar, G., Palmisano, R., Waibel, R., Einsiedel, J., Dürr, M., Ivanović-Burmazović, I., Larsen, Olav, Hjortø, Gertrud Malene, Rosenkilde, M. M. & Tschammer, N., 2016, In: Journal of Medicinal Chemistry. 59, 5, p. 2222-2243 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Natural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo
Janssens, R., Mortier, A., Boff, D., Vanheule, V., Gouwy, M., Franck, C., Larsen, Olav, Rosenkilde, Mette, Damme, J. V., Amaral, F. A., Teixeira, M. M., Struyf, S. & Proost, P., 2016, In: OncoTarget. 7, 38, p. 62439-62459 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo
Spiess, Katja, Jeppesen, M. G., Malmgaard-Clausen, M., Krzywkowski, K., Dulal, K., Cheng, T., Hjortø, Gertrud Malene, Larsen, Olav, Burg, J. S., Jarvis, M. A., Garcia, K. C., Zhu, H., Kledal, T. N. & Rosenkilde, Mette, Jul 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 27, p. 8427-8432 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
- Published
Prevalences of HTLV-1 infection and associated risk determinants in an urban population in Guinea-Bissau, West Africa
Larsen, Olav, Andersson, S., da Silva, Z., Hedegaard, K., Sandstrom, A., Naucler, A., Dias, F., Melbye, M. & Aaby, P., 1 Oct 2000, In: Journal of Acquired Immune Deficiency Syndromes. 25, 2, p. 157-163Research output: Contribution to journal › Journal article › Research › peer-review
- 1998
- Published
HTLV-1 infection in a population-based cohort of older persons in Guinea-Bissau, West Africa: Risk factors and impact on survival
Melbye, M., Poulsen, A., Gallo, D., Pedersen, J., Biggar, R., Larsen, Olav, Dias, F. & Aaby, P., 4 May 1998, In: International Journal of Cancer. 76, 3, p. 293-298Research output: Contribution to journal › Journal article › Research › peer-review
- 1996
- Published
Aggression and personality: Association with amino acids and monoamine metabolites
Møller, Søren, Mortensen, Erik Lykke, Breum, Leif, Alling, C., Larsen, Olav, Bøge-Rasmussen, T., Jensen, C. & Bennicke, K., Mar 1996, In: Psychological Medicine. 26, 2, p. 323-331 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 138841170
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445
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Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
375
downloads
Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
304
downloads
Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration
Research output: Contribution to journal › Journal article › Research › peer-review
Published