Birgitte Holst
Guest Researcher
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
- Published
Modulation of the constitutive activity of the ghrelin receptor by use of pharmacological tools and mutagenesis
Mokrosinski, J. & Holst, Birgitte, Jan 2010, In: Methods in Enzymology. 484, p. 53-73 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop
Mokrosinski, J., Frimurer, Thomas Michael, Sivertsen, B., Schwartz, Thue W. & Holst, Birgitte, Sep 2012, In: Journal of Biological Chemistry. 287, p. 33488-33502 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Translating biased signaling in the ghrelin receptor system into differential in vivo functions
Mende, F., Johnsen, Cecilie Hundahl, Plouffe, B., Skov, Louise Julie, Sivertsen, B., Madsen, A. N., Lückmann, Michael, Diep, T. A., Offermanns, S., Frimurer, Thomas Michael, Bouvier, M. & Holst, Birgitte, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 43, p. E10255-E10264 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype
Martini, L., Hastrup, H., Holst, Birgitte, Fraile-Ramos, A., Marsh, M. & Schwartz, Thue W., 2002, In: Molecular Pharmacology. 62, 1, p. 30-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In Silico Investigation of the Neurotensin Receptor 1 Binding Site: Overlapping Binding Modes for Small Molecule Antagonists and the Endogenous Peptide Agonist
Lückmann, Michael, Holst, Birgitte, Schwartz, Thue W. & Frimurer, Thomas Michael, 2016, In: Molecular Informatics. 35, p. 19-24 6 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
The Zinc-Sensing Receptor GPR39 in Physiology and as a Pharmacological Target
Laitakari, Anna Isabella, Liu, L., Frimurer, Thomas Michael & Holst, Birgitte, 2021, In: International Journal of Molecular Sciences. 22, 8, 22 p., 3872.Research output: Contribution to journal › Review › Research › peer-review
- Published
C4.4A gene ablation is compatible with normal epidermal development and causes modest overt phenotypes
Kriegbaum, M. C., Jacobsen, B., Fuchtbauer, A., Hansen, Gert Helge, Christensen, I. J., Friis, Carsten, Persson, M., Engelholm, Lars Henning, Madsen, A. N., Di Meo, I., Lund, I. K., Holst, Birgitte, Kjær, Andreas, Laerum, O. D., Fuchtbauer, E. & Ploug, Michael, 12 May 2016, In: Scientific Reports. 6, 25833.Research output: Contribution to journal › Journal article › Research › peer-review
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Neprilysin activity is increased in metabolic dysfunction-associated steatotic liver disease and normalizes after bariatric surgery or GLP-1 therapy
Kjeldsen, S. A. S., Gluud, L. L., Werge, M. P., Pedersen, J. S., Bendtsen, F., Alexiadou, K., Tan, T., Torekov, S. S., Iepsen, E. W., Jensen, N. J., Richter, M. M., Goetze, J. P., Rungby, J., Hartmann, B., Holst, J. J., Holst, B., Holt, J., Gustafsson, F., Madsbad, S., Svane, M. S. & 2 others, , 2023, In: iScience. 26, 11, 13 p., 108190.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biased Ghrelin Receptor Signaling and the Dopaminergic System as Potential Targets for Metabolic and Psychological Symptoms of Anorexia Nervosa
Khelifa, M. S., Skov, Louise Julie & Holst, Birgitte, 2021, In: Frontiers in Endocrinology. 12, 13 p., 734547.Research output: Contribution to journal › Review › Research › peer-review
- Published
Impaired glucose metabolism and altered gut microbiome despite calorie restriction of ob/ob mice
Kashani, A., Brejnrod, A. D., Jin, C., Kern, T., Madsen, A. N., Holm, L. A., Gerber, G. K., Holm, Jens-Christian, Hansen, Torben, Holst, Birgitte & Arumugam, Mani, 2019, In: Animal Microbiome. 1, 1, 16 p., 11.Research output: Contribution to journal › Journal article › Research › peer-review
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Anxiolytic-Like Effects of Increased Ghrelin Receptor Signaling in the Amygdala
Jensen, M., Ratner, C., Rudenko, Olga, Christiansen, S. H., Skov, Louise Julie, Johnsen, Cecilie Hundahl, Woldbye, David Paul Drucker & Holst, Birgitte, 1 May 2016, In: International Journal of Neuropsychopharmacology. 19, 5, 12 p., pyv123.Research output: Contribution to journal › Journal article › Research › peer-review
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Hypothalamic hormone-sensitive lipase regulates appetite and energy homeostasis
Johnsen, Cecilie Hundahl, Kotzbeck, P., Burm, Hayley Beth, Christiansen, S. H., Pedersen, Lola Julie Torz, zmw799, zmw799, Madsen, M. P., Ratner, C., Serup, A. K., Thompson, J. J., Eichmann, T. O., Pers, Tune H, Woldbye, David Paul Drucker, Piomelli, D., Kiens, Bente, Zechner, R., Skov, Louise Julie & Holst, Birgitte, 2021, In: Molecular Metabolism. 47, 16 p., 101174.Research output: Contribution to journal › Journal article › Research › peer-review
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Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity
Holst, Peter Johannes, Rosenkilde, Mette, Manfra, D., Chen, S. C., Wiekowski, M. T., Holst, Birgitte, Cifire, F., Lipp, M., Schwartz, Thue W. & Lira, S. A., 2001, In: Journal of Clinical Investigation. 108, 12, p. 1789-96 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe
Holst, Birgitte & Schwartz, Thue W., 2003, In: Annals of the New York Academy of Sciences. 994, p. 1-11 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist
Holst, Birgitte, Cygankiewicz, A., Jensen, T. H., Ankersen, M. & Schwartz, Thue W., 2003, In: Molecular Endocrinology. 17, 11, p. 2201-10 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ghrelin receptor mutations--too little height and too much hunger
Holst, Birgitte & Schwartz, Thue W., 2006, In: Journal of Clinical Investigation. 116, 3, p. 637-41 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction
Holst, Birgitte, Egerod, Kristoffer Lihme, Jin, C., Petersen, P. S., Østergaard, M. V., Hald, J., Sprinkel, A. M. E., Størling, J., Mandrup-Poulsen, Thomas, Holst, Jens Juul, Thams, P., Orskov, C., Wierup, N., Sundler, F., Madsen, O. D. & Schwartz, Thue W., 2009, In: Endocrinology. 150, 6, p. 2577-85 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor
Holst, Birgitte, Frimurer, T. M., Mokrosinski, J., Halkjaer, T., Cullberg, K. B., Underwood, C. R. & Schwartz, Thue W., 2008, In: Molecular Pharmacology. 75, 1, p. 44-59 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors
Holst, Birgitte, Nygaard, R., Hansen, L. V., Bach, Anders, Engelstoft, M. S., Petersen, P. S., Frimurer, T. M. & Schwartz, Thue W., 2010, In: Journal of Biological Chemistry. 285, 6, p. 3973-85 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation
Holst, Birgitte & Schwartz, Thue W., 2004, In: TIPS - Trends in Pharmacological Sciences. 25, 3, p. 113-7 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling
Holst, Birgitte, Brandt, E., Bach, Anders, Heding, A. & Schwartz, Thue W., 2005, In: Molecular Endocrinology. 19, 9, p. 2400-11 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism
Holst, Birgitte, Mokrosinski, J., Lang, M., Brandt, E., Nygaard, R., Frimurer, T. M., Beck-Sickinger, A. G. & Schwartz, Thue W., 2007, In: Journal of Biological Chemistry. 282, 21, p. 15799-811 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
Holst, Birgitte, Madsen, Kenneth Lindegaard, Jansen, A. M., Jin, C., Rickhag, Karl Mattias, Lund, Viktor Karlovich, Jensen, M., Bhatia, V., Sørensen, G., Madsen, A. N., Xue, Z., Møller, S. K., Woldbye, David Paul Drucker, Qvortrup, Klaus, Huganir, R., Stamou, Dimitrios, Kjærulff, Ole & Gether, Ulrik, Apr 2013, In: P L o S Biology (Online). 11, 4, p. 1-25 25 p., e1001542.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPR39 signaling is stimulated by zinc ions but not by obestatin
Holst, Birgitte, Egerod, Kristoffer Lihme, Schild, E., Vickers, S. P., Cheetham, S., Gerlach, L., Storjohann, L., Stidsen, C. E., Jones, R., Beck-Sickinger, A. G. & Schwartz, Thue W., 2006, In: Endocrinology. 148, 1, p. 13-20 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Steric hindrance mutagenesis versus alanine scan in mapping of ligand binding sites in the tachykinin NK1 receptor
Holst, Birgitte, Jensen, S. Z., Elling, C. E., Hjorth, S. A. & Schwartz, Thue W., 1998, In: Molecular Pharmacology. 53, no. 1, p. 166-175Research output: Contribution to journal › Journal article › Research › peer-review
ID: 9886
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Dietary non-esterified oleic Acid decreases the jejunal levels of anorectic N-acylethanolamines
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Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity
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PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
Research output: Contribution to journal › Journal article › Research › peer-review
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