Regulation of microvascular tone

Biology appears to be largely characterized by a precise temporal and spatial organization. On the other hand, however, many transient interventions that alter the organisation within a biological system do not induce any significant pathology in the system.

Moreover, upon dissecting similar biological tissue, e.g. heart tissue or a specific vascular bed, the finer biological details seem to be fairly heterogeneous. Thus, biology may also be characterized by an equally high degree of plasticity and robustness. The unfolding of the underlying nature of these phenomena is of great personal interest.

In the vasculature, these features are very clear. The dynamics of signalling systems produce a precise regulation of the vascular beds although the systems are build from an underlying heterogeneous basis. We use a mathematical modelling approach to investigate the dynamics of

  1. Propagated signalling responses across large distances 
  2. The intercellular synchronization of smooth muscle cells of the arteriolar wall.

Analysis of simulated signalling responses from underlying models of heterogeneous vascular cells may furnish a better understanding of both vascular signalling pathways and the robustness of biological systems as such.

Bjørn Olav Hald is focused on this research area. If you want to know more about Bjørn's research, please contact him.