Physiology of Ion Channel Complexes

Ion channels are proteins that control a wide spectrum of physiological processes. They allow the passage of ions such as potassium, sodium, chloride and calcium across cellular membranes. This makes them key elements to cellular communication – they enable cells to relay electrical messages not only into and out of the cells, but also between cells. When ion channels work, we can observe a well-conducted symphony orchestra of physiological processes where each channel hits the right tone. If they do not work as they should, things can go really bad: cardiac arrhythmia, epilepsy, hypertension, disturbed insulin secretion, infertility, just to mention a few examples for possible cacophonies.

My research focuses on the impact of mutations, molecular regulatory mechanisms and accessory subunits on the function of ion channel complexes with special focus on cardiac arrhythmia. Because we can observe many of the studied channels in a variety of tissues, we are also interested in their characterization in e.g. neurons, pancreatic cells, and the vasculature. Observing different functional patterns in different organs gives us valuable hints for understanding the complexity (and beauty) of human physiology.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Group leader Nicole Schmitt

Group Leader
Nicole Schmitt
Professor with special responsibilities

Phone +45 35327448
nschmitt@sund.ku.dk

 

Group members

Name Title Phone E-mail
Louise Koch Laboratory Technician +4535336704 E-mail