Physiology of Ion Channel Complexes
My research is focused on the impact of mutations, molecular regulatory mechanisms and accessory subunits on the function of ion channel complexes with special focus on cardiac arrhythmia. Many studies dealt with the molecular regulation and biophysical mechanisms behind ion channel dysfunction observed in cardiac arrhythmia, especially in atrial fibrillation, Brugada syndrome and Long QT syndrome.
Due to the fact that many of the studied channels are expressed in a variety of tissues, we are also interested in their characterization in e.g. neurons, pancreatic cells, and the vasculature. Here, the different patterns observed in different organs give valuable hints for the understanding of the complexity (and beauty) of human physiology.
Further core areas of my research are the molecular mechanisms of cardiac ion channel trafficking, and the posttranslational modification and regulation of cardiac ion channel complexes.
- Molecular understanding of cardiac arrhythmia with focus on atrial fibrillation;
- Beyond the genes – unravelling epigenetic mechanisms leading to heart disease;
- Physiology and pathophysiology of KCNE potassium channel subunits in the heart and elsewhere.
|Prof. Melvin Scheinman
(University of California San Francisco, USA)
|Functional characterization of congenital ion channel mutations associated with cardiac arrhythmia|
|Prof. Guiscard Seebohm
(U Muenster, Germany)
|Molecular mechanisms of potassium channel regulation in health and disease|
|Assoc. prof. Morten Salling Olesen (University Hospital of Copenhagen – Rigshospitalet – , Denmark)||Genetics and molecular basis for early-onset lone atrial fibrillation, long-term collaboration|
|Assoc. prof. Jean-François Perrier (Dept. of Neuroscience and Pharmacology, University of Copenhagen, Denmark)||Application of molecular and biochemical techniques in neuroscience|
|Prof. Lars Ellgard
(Dept. of Biology, University of Copenhagen, Denmark)
|Determination of the molecular mechanisms underlying protein folding|
Nicole Schmitt is part of the Department's Leadership Team. She is also in involved in a number of Steering Groups and Committees at Faculty and University level.
Activities in undergraduate teaching comprise both, class room teaching and project supervision. Find more information about teaching at BMI.
For examples of accomplished bachelor and Master projects in various study courses (Medicine, Biochemistry, Medicine and Technology, Molecular Biomedicine, Human Biology).
- Supervision of PhD projects
- Organization of PhD courses