Members of the Immuno-endocrinology lab

Thomas Mandrup-PoulsenProfessor Mandrup-Poulsen is a physician scientist and board certified in internal medicine and endocrinology. He serves as Professor at the University of Copenhagen and as an adjunct professor in Immuno-diabetology at the Karolinska Institute in Stockholm. His research focuses on understanding inflammatory and oxidative beta-cell death leading to diabetes, and his discovery that proinflammatory cytokines cause beta-cell functional failure and destruction qualified him for the 1994 Oskar Minkowski prize of the European Association for the Study of Diabetes. He has been leading PI or co-PI of EU and JDRF (USA) grants, three international multicenter clinical studies and had leadership roles in the data safety monitoring board/advisory boards in two international multicenter clinical studies.

See Thomas Mandrup-Poulsen's full CV and publication list.
See Thomas Mandrup-Poulsen's two courses Theoretical pathophysiology, Experimental pathophysiology. You need login to Absalon in order to gain access to the courses.

Michal MarzecMichal Marzec, MD, PhD has joined the Immuno-endocrinology Section as an Assistant Professor supported by a DFF Marie Curie Mobilex Grant.  

Over the years, Michal's research interest has shifted from understanding oncogenic pathways to providing answers to why and how organisms differ in their susceptibility to diseases. Recent massive sequencing of thousands of individuals made it possible to study the impact of human variations on pathological processes underlying multiple diseases. He joined Prof. Argon’s laboratory, to work on the involvement of GRP94 in the maturation and secretion of IGF molecules. Subsequently, he described the first human variant of GRP94 and its role in the pathogenesis of Primary IGF Deficiency.

Currently Michal is applying his expertise into diabetes pathology where he is investigating the role of endoplasmic reticulum chaperones in proinsulin folding. In addition he is exploring the possible link between population genetic variability of protein chaperones and the susceptibility to diabetes.

See Michal Marzec's full CV. Please also see Michal Marze's  profile and publication list.

Tina DahlbyTina Dahlby (MSc in Biochemistry) is employed as a PhD student at the Department of Biomedical Sciences, University of Copenhagen.

The main objective of Tina’s work is to investigate how selective histone deacetylase (HDAC) inhibition can rescue pancreatic β cells from the damaging effects of nutrient overload (glucolipotoxicity, GLT) associated with type 2 diabetes. The work is focused on investigating HDAC-mediated expression and/or activation of key candidate enzymes in order to clarify the pathway utilized by these candidates to switch the GLT-induced endoplasmic reticulum stress response from protective to proapoptotic, aiming towards the development of novel antidiabetic drugs.

Seyed Mojtaba GhiasiSeyed Mojtaba Ghiasi is employed as a research associate at the department of Biomedical Sciences. The main objective of Seyed’s research is to investigate protective actions of Rotigaptide on oxidative stress. He has also focused on the impact of RNA oxidation on insulin-producing beta-cell function. Although Seyed has recently started his investigation in the field of diabetes, with getting very promising primary results, he aims to dissect Rotigaptide-induced signaling pathways ending to cell survival and beta-cell function rescue using many various techniques in cellular and molecular biology. In addition, Seyed also interests in exploring whether the antiarrhythmic drug Rotigaptide with its antioxidant activity is able to decrease RNA oxidation. So far based on current data, using in vitro, ex vivo and in vivo studies he wants to identify target transducers interplayed between mitochondrial and endoplasmic reticulum stress signaling pathways. He strongly plans to do his PhD research by bridging this project with role of RNA oxidation in beta-cell function.

See Seyed's full CV. Please also see Seyed Ghiasi's profile and publication list.

Muhammad SaadMuhammad Saad is employed as PhD student in the Department of Biomedical Sciences, University of Copenhagen. Earlier he earned his bachelors (Doctor of Veterinary Medicine) and Masters (Physiology) from Pakistan.

The focus of Saad’s research will be on auto-immune mechanisms related to type-1 diabetes. He will explore the role of GRP94 in processing of pro-insulin. Also he will investigate the potential involvement of proteasomes in pro-insulin degradation.

Lisa ChristenLisa Christen (MSc in Biotechnology with the focus on Cell Biology) is employed as research assistant at the Department of Biomedical Sciences, University of Copenhagen. She has jointed the group already during her master thesis project in 2016.

Currently the main objective of Lisa’s project is to investigate the role of autophagy in inflammation-mediated beta-cell damage. Thereby, she works with different immortalized diabetic cell lines and uses diverse cell based assays (Griess reagent assays, cell viability assays, ELISA) and microscopic techniques to reach the aims.

Celine PhilCelina Phil (Bsc in Molecular Biomedicine) is currently taking her MSc in Molecular Biomedicine. Celina wrote her bachelor’s thesis in the immune-endocrinology lab, writing about GRP94, ER stress and degradative pathways.

As a continuation of work previously done in the lab, Celina is now focusing her research on proteins co-interacting with GRP94 and proinsulin. The goal is to give a comprehensive picture of the relationship between ER chaperones and modulating proteins, and to investigate their collaborative effect on insulin biosynthesis and processing.

Sophie Emilie BressonSophie Emilie Bresson (Bsc in Molecular Biomedicine, UCPH) has joined the group as a master student, while completing the program in Molecular Biomedicine.

Sophie joined the Immuno-Endocrinology lab in January of 2018 as a bachelor’s student where her project focused on investigating the interaction between endogenous GRP94 and proinsulin, as well as determining novel interaction partners of the complex.

This work has lead Sophie to continue with the lab, now focusing her master’s project on characterizing variations in either GRP94 or proinsulin and investigating their effects on the complex formation and insulin synthesis.

As such, this work aims to further our understanding of protein folding and ER stress and its influence on diabetes.

Tenna Bryde (BSc in Biology, UCPH) has a strong research interest in diabetes. She joined the group as a master student in Cell Biology and Physiology in September 2018 to fulfill her interest and contribute to diabetes and beta-cell research.

The goal of Tenna’s research is to evaluate the biological role of proteins co-interacting with GRP94 and proinsulin. To do so, Tenna is currently working with different cell lines and cell-based assays such as ELISA and GSIS. The achievements of her work will expand the understanding of the relationship between ER stress, protein folding, and insulin biosynthesis.

Philip AndersenPhilip Andersen (BSc in Molecular Biomedicine, UCPH) is taking his MSc in Molecular Biomedicine in the group. The focus of Philip's work is to investigate how the circadian clock is regulated in pancreatic β-cells.