Immuno-endocrinology - in health and disease
We work to prevent and cure type 1 and type 2 diabetes by targeting the inflammatory pathways leading to pancreatic beta-cell failure. Ongoing projects define the transcriptional, translational and posttranslational responses of the pancreatic beta-cell to immune, inflammatory, metabolic and oxidative stress, with the aim of identifying novel therapeutic targets to be tested in preclinical models and clinical trials.
Understand the intersection of the immune andendocrine systems
Immuno-endocrinology is a rapidly developing field of research that seeks to understand the intersection of the immune and endocrine systems. The mutual regulation of immune and endocrine functions by hormones and immune mediators such as cytokines is an exciting evolving field in physiology.
The immune system is the largest endocrine organ
More and more hormones are found to affect immune function, and cytokines are increasingly recognised to have homeostatic importance and to exert auto-, para- and endocrine actions. This makes the immune system the largest endocrine organ in the body.
Mangage non-curable diseases
Autoimmune and inflammatory endocrinopathies are non-curable diseases, and clinical management focuses on either hormonal substitution therapy or disease activity modification. Substitution therapy of most hormonal deficiencies secondary to inflammatory endocrine tissue destruction is gratifying and restores normal life quality and expectancy. Notable exceptions from these are type 1 and type 2 diabetes that are notoriously problematic to manage and still associated with significant over-morbidity and mortality. Therefore these diseases present pressing needs for better causative treatments based on detailed insights into the molecular and cellular pathogenetic mechanisms.