Human Gut Transport
The Human Gut Transport Lab has developed a mini-ussing chamber due to the fact that it has been difficult to study functional receptors and related diseases in the human gastrointestinal tract at a cellular level.
In the mini-ussing chamber, gut endoscopic biopsies may be mounted with air suction for the study of neuro-, endo-, and paracrine receptor subtypes involved in epithelial transport.
We seek to characterize especially functional receptor subtypes for serotonin and prostaglandins in human duodenum and colon.
Serotonergic receptors: We determine serotonergic receptors involved in duodenal secretion combined with studies of control and dyspeptic patient with a focus on ulcus.
Prostaglandin E2 receptors: We determine the prostaglandin E2 receptors in control and colorectal cancer patients with the purpose of revealing links between the cancer disease and expression of various E2 subtype receptors.