The focus of the research is to develop tools to analyze dose-response effects at equilibrium in pharmaco-dynamics and combinatorial drug therapy.
Present analyses of allosteric dose-response functions rely heavily on operational models and Hill’s exponentiation. The non-mechanistic Hill expression, solving for black-box parameters, has dominated the field for more than 100 years. It is an empirical tool.
Aim of the research
The aim of the research is to introduce new mechanistic models for analysis and simulation of dose-response relations at equilibrium, “synagics”, in genuine allosteric two-state models - instead of operational models and sliding down hill slopes.