Cardiac Physiology Laboratory
In the Cardiac Physiology Laboratory, we aim at elucidating the physiological function of membrane embedded and associated proteins, through molecular, biochemical, pharmacological, and electrophysiological investigations.
Our primary research focus is on cardiac electrophysiology and arrhythmias. However, we also have ongoing projects reaching from metabolic diseases to neuronal disorders.
The focus is on revealing novel functional roles of ion channels and receptors localized in cardiac and epithelial tissue as well as in CNS. Our goal is to incorporate in vitro findings into a whole organ context by the use of ex vivo and in vivo animal models.
In the Cardiac Physiology Laboratory, we focus on mechanisms leading to cardiac diseases and arrhythmias through studying the regulation of membrane proteins, with a major focus on ion channels and receptors in the heart.
We use electrophysiological, pharmacological and molecular tools to investigate physiological functions. Furthermore, potent and selective pharmacological molecules are pivotal in a number of our atrial fibrillation and long-QT and cardiac infarct studies, where we use these to delineate a potential beneficial effect in treating the disease.
Our projects are designed to reveal novel aspects of membrane protein complexes. Several different approaches and techniques are often used which make it possible to perform investigations from molecule to whole organ, whereby the physiological importance of the findings can be established.
The groups’ main research projects in dealing with unravelling the mechanisms that are involved with rhythm disorders (arrhythmias) in the heart. Several projects are focusing on both supraventricular as vel as ventricular arrhythmias.
We use both pharmacological and molecular tools to investigate physiological functions. Further, different pharmacological compounds are pivotal in a number of our atrial fibrillation studies where we use these to delineate a potential beneficial effect in treating the disease.
The group's main interest is sodium and potassium currents, as well as receptors and intracellular mechanisms involved in regulating the channel complexes underlying these currents.
Some of our currently running projects are:
- Acute myocardial infarction and sudden cardiac death in a pig model (MI-RISK)
- Action potential measurements in human cardiac tissue
- Treatment of heart failure in the SHHF rat model
- SK potassium current in atria and atrial fibrillation
- Electrical characterisation of the horse heart
- Regulation of ion channel activity by ubiquitylation and de-ubiquitylation
- Receptor regulation of GIRK ion channels
- Ion channel mutations underlying cardiac arrhythmia
- In vivo genetic manipulation of cardiac ion channels
- Epilepsy/Dravet Syndrome: Pharmacological intervention of Nav1.1 channel activity