Rune E. Kuhre receives two-year postdoc grant from the Lundbeck Foundation
Postdoc Rune E. Kuhre from Jens Juul Holst’s group has received DKK 1.4 million from the Lundbeck Foundation for a two-year postdoc where he will work on the project “The role of Somatostatin and Urocrotin-3 for Regulation of Glucagon Secretion”.
Rune Ehrenreich Kuhre, who is a part of Jens Juul Holst’s research group, has received DKK 1,4 million from the Lundbeck Foundation for a project entitled “The role of Somatostatin and Urocrotin-3 for Regulation of Glucagon Secretion”.
Rune’s project will investigate whether the inhibitory effect of sugar (glucose) on glucagon secretion is mediated indirectly via the peptides urocortin-3 and somatostatin which is produced by neighbouring cells to the alpha cell and possibly acts as paracrine inhibitory signal molecules on the pancreatic alpha cell.
“Glucagon is secreted from the alpha cells of the islet of the Langerhans in the pancreas and maintains the blood sugar level during fasting. When the blood sugar level rises (after food intake), glucagon secretion is attenuated within few minutes but the underlying mechanism(s) responsible for this inhibition has yet to be understood in detail,” says Rune about his project.