Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses

Research output: Contribution to journal › Review › Research › peer-review

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Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses. / Rosenkilde, Mette M.; Tsutsumi, Naotaka; Knerr, Julius M.; Kildedal, Dagmar F.; Garcia, K. Christopher.

In: Annual Review of Virology, Vol. 9, No. 1, 2022, p. 329-351.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Rosenkilde, MM, Tsutsumi, N, Knerr, JM, Kildedal, DF & Garcia, KC 2022, 'Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses', Annual Review of Virology, vol. 9, no. 1, pp. 329-351. https://doi.org/10.1146/annurev-virology-100220-113942

APA

Rosenkilde, M. M., Tsutsumi, N., Knerr, J. M., Kildedal, D. F., & Garcia, K. C. (2022). Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses. Annual Review of Virology, 9(1), 329-351. https://doi.org/10.1146/annurev-virology-100220-113942

Vancouver

Rosenkilde MM, Tsutsumi N, Knerr JM, Kildedal DF, Garcia KC. Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses. Annual Review of Virology. 2022;9(1):329-351. https://doi.org/10.1146/annurev-virology-100220-113942

Author

Rosenkilde, Mette M. ; Tsutsumi, Naotaka ; Knerr, Julius M. ; Kildedal, Dagmar F. ; Garcia, K. Christopher. / Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses. In: Annual Review of Virology. 2022 ; Vol. 9, No. 1. pp. 329-351.

Bibtex

@article{7f9c91273812410ebf6be5ab1ff73520,
title = "Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses",
abstract = "Herpesviruses are ancient large DNA viruses that have exploited gene capture as part of their strategy to escape immune surveillance, promote virus spreading, or reprogram host cells to benefit their survival. Most acquired genes are transmembrane proteins and cytokines, such as viral G protein-coupled receptors (vGPCRs), chemokines, and chemokine-binding proteins. This review focuses on the vGPCRs encoded by the human β- and γ-herpesviruses. These include receptors from human cytomegalovirus, which encodes four vGPCRs: US27, US28, UL33, and UL78; human herpesvirus 6 and 7 with two receptors: U12 and U51; Epstein-Barr virus with one: BILF1; and Kaposi's sarcoma-associated herpesvirus with one: open reading frame 74, ORF74. We discuss ligand binding, signaling, and structures of the vGPCRs in light of robust differences from endogenous receptors. Finally, we briefly discuss the therapeutic targeting of vGPCRs as future treatment of acute and chronic herpesvirus infections.",
keywords = "broad-spectrum ligand binding, chemokine receptor, G protein signaling, GPCR structure, herpesvirus",
author = "Rosenkilde, {Mette M.} and Naotaka Tsutsumi and Knerr, {Julius M.} and Kildedal, {Dagmar F.} and Garcia, {K. Christopher}",
year = "2022",
doi = "10.1146/annurev-virology-100220-113942",
language = "English",
volume = "9",
pages = "329--351",
journal = "Annual Review of Virology",
issn = "2327-056X",
publisher = "Annual Reviews, inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses

AU - Rosenkilde, Mette M.

AU - Tsutsumi, Naotaka

AU - Knerr, Julius M.

AU - Kildedal, Dagmar F.

AU - Garcia, K. Christopher

PY - 2022

Y1 - 2022

N2 - Herpesviruses are ancient large DNA viruses that have exploited gene capture as part of their strategy to escape immune surveillance, promote virus spreading, or reprogram host cells to benefit their survival. Most acquired genes are transmembrane proteins and cytokines, such as viral G protein-coupled receptors (vGPCRs), chemokines, and chemokine-binding proteins. This review focuses on the vGPCRs encoded by the human β- and γ-herpesviruses. These include receptors from human cytomegalovirus, which encodes four vGPCRs: US27, US28, UL33, and UL78; human herpesvirus 6 and 7 with two receptors: U12 and U51; Epstein-Barr virus with one: BILF1; and Kaposi's sarcoma-associated herpesvirus with one: open reading frame 74, ORF74. We discuss ligand binding, signaling, and structures of the vGPCRs in light of robust differences from endogenous receptors. Finally, we briefly discuss the therapeutic targeting of vGPCRs as future treatment of acute and chronic herpesvirus infections.

AB - Herpesviruses are ancient large DNA viruses that have exploited gene capture as part of their strategy to escape immune surveillance, promote virus spreading, or reprogram host cells to benefit their survival. Most acquired genes are transmembrane proteins and cytokines, such as viral G protein-coupled receptors (vGPCRs), chemokines, and chemokine-binding proteins. This review focuses on the vGPCRs encoded by the human β- and γ-herpesviruses. These include receptors from human cytomegalovirus, which encodes four vGPCRs: US27, US28, UL33, and UL78; human herpesvirus 6 and 7 with two receptors: U12 and U51; Epstein-Barr virus with one: BILF1; and Kaposi's sarcoma-associated herpesvirus with one: open reading frame 74, ORF74. We discuss ligand binding, signaling, and structures of the vGPCRs in light of robust differences from endogenous receptors. Finally, we briefly discuss the therapeutic targeting of vGPCRs as future treatment of acute and chronic herpesvirus infections.

KW - broad-spectrum ligand binding

KW - chemokine receptor

KW - G protein signaling

KW - GPCR structure

KW - herpesvirus

UR - http://www.scopus.com/inward/record.url?scp=85138507259&partnerID=8YFLogxK

U2 - 10.1146/annurev-virology-100220-113942

DO - 10.1146/annurev-virology-100220-113942

M3 - Review

C2 - 35671566

AN - SCOPUS:85138507259

VL - 9

SP - 329

EP - 351

JO - Annual Review of Virology

JF - Annual Review of Virology

SN - 2327-056X

IS - 1

ER -

ID: 323196744