The incretin effect does not differ in trained and untrained, young, healthy men

Research output: Contribution to journal › Journal article › peer-review

Standard

The incretin effect does not differ in trained and untrained, young, healthy men. / Lund, Michael Taulo; Dalby, Sina; Hartmann, Bolette; Helge, Jørn Wulff; Holst, Jens Juul; Dela, Flemming.

In: Acta Physiologica, Vol. 210, No. 3, 03.2014, p. 565-72.

Research output: Contribution to journal › Journal article › peer-review

Harvard

Lund, MT, Dalby, S, Hartmann, B, Helge, JW, Holst, JJ & Dela, F 2014, 'The incretin effect does not differ in trained and untrained, young, healthy men', Acta Physiologica, vol. 210, no. 3, pp. 565-72. https://doi.org/10.1111/apha.12218

APA

Lund, M. T., Dalby, S., Hartmann, B., Helge, J. W., Holst, J. J., & Dela, F. (2014). The incretin effect does not differ in trained and untrained, young, healthy men. Acta Physiologica, 210(3), 565-72. https://doi.org/10.1111/apha.12218

Vancouver

Lund MT, Dalby S, Hartmann B, Helge JW, Holst JJ, Dela F. The incretin effect does not differ in trained and untrained, young, healthy men. Acta Physiologica. 2014 Mar;210(3):565-72. https://doi.org/10.1111/apha.12218

Author

Lund, Michael Taulo ; Dalby, Sina ; Hartmann, Bolette ; Helge, Jørn Wulff ; Holst, Jens Juul ; Dela, Flemming. / The incretin effect does not differ in trained and untrained, young, healthy men. In: Acta Physiologica. 2014 ; Vol. 210, No. 3. pp. 565-72.

Bibtex

@article{8390e92c59ef400e93e19e4199de18b2,
title = "The incretin effect does not differ in trained and untrained, young, healthy men",
abstract = "Aim: After both oral and intravenous glucose administration, peripheralinsulin concentrations are lower in trained compared with untrainedhumans. Part of this is explained by an adaptation within the b-cell. Theinsulin secretion rate is higher after oral compared with intravenous glucoseadministration due to the release of glucagon-like peptide-1 (GLP-1)and glucose-dependent insulinotropic polypeptide (GIP) enhancing the glucose-induced insulin secretion (the incretin effect). Our aim was to investigatewhether GIP or GLP-1 release or the incretin effect was different intrained compared with untrained humans after oral and intravenousglucose administration.Methods: A 3½-h oral glucose tolerance test was performed in eleventrained and ten untrained, young, healthy men. On a separate day, an isoglycaemicintravenous glucose infusion was performed matching the individualglucose concentrations obtained during the oral glucose tolerancetest. Blood samples for insulin, C-peptide, GIP and GLP-1 analyses wereobtained frequently during both tests, and the insulin secretion rate, incretineffect and insulin clearance were calculated.Results: Plasma GIP and GLP-1 concentrations, the incretin effect and theinsulin clearance did not differ, and plasma glucose, insulin and C-peptideconcentrations and the insulin secretion rate were lower in trained comparedwith untrained subjects during both tests.Conclusion: With no difference in incretin effect and insulin clearancebetween the two groups, the lower plasma insulin concentrations found intrained compared with untrained, young, healthy men are most likelyexplained by lower b-cell sensitivity to glucose and enhanced glucoseuptake in skeletal muscle in the former group.",
keywords = "Faculty of Health and Medical Sciences, Incretin, insulin, GLP-1, GIP, Exercise, Training, Glucose",
author = "Lund, {Michael Taulo} and Sina Dalby and Bolette Hartmann and Helge, {J{\o}rn Wulff} and Holst, {Jens Juul} and Flemming Dela",
note = "{\textcopyright} 2013 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.",
year = "2014",
month = mar,
doi = "10.1111/apha.12218",
language = "English",
volume = "210",
pages = "565--72",
journal = "Acta Physiologica",
issn = "1748-1708",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - The incretin effect does not differ in trained and untrained, young, healthy men

AU - Lund, Michael Taulo

AU - Dalby, Sina

AU - Hartmann, Bolette

AU - Helge, Jørn Wulff

AU - Holst, Jens Juul

AU - Dela, Flemming

N1 - © 2013 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.

PY - 2014/3

Y1 - 2014/3

N2 - Aim: After both oral and intravenous glucose administration, peripheralinsulin concentrations are lower in trained compared with untrainedhumans. Part of this is explained by an adaptation within the b-cell. Theinsulin secretion rate is higher after oral compared with intravenous glucoseadministration due to the release of glucagon-like peptide-1 (GLP-1)and glucose-dependent insulinotropic polypeptide (GIP) enhancing the glucose-induced insulin secretion (the incretin effect). Our aim was to investigatewhether GIP or GLP-1 release or the incretin effect was different intrained compared with untrained humans after oral and intravenousglucose administration.Methods: A 3½-h oral glucose tolerance test was performed in eleventrained and ten untrained, young, healthy men. On a separate day, an isoglycaemicintravenous glucose infusion was performed matching the individualglucose concentrations obtained during the oral glucose tolerancetest. Blood samples for insulin, C-peptide, GIP and GLP-1 analyses wereobtained frequently during both tests, and the insulin secretion rate, incretineffect and insulin clearance were calculated.Results: Plasma GIP and GLP-1 concentrations, the incretin effect and theinsulin clearance did not differ, and plasma glucose, insulin and C-peptideconcentrations and the insulin secretion rate were lower in trained comparedwith untrained subjects during both tests.Conclusion: With no difference in incretin effect and insulin clearancebetween the two groups, the lower plasma insulin concentrations found intrained compared with untrained, young, healthy men are most likelyexplained by lower b-cell sensitivity to glucose and enhanced glucoseuptake in skeletal muscle in the former group.

AB - Aim: After both oral and intravenous glucose administration, peripheralinsulin concentrations are lower in trained compared with untrainedhumans. Part of this is explained by an adaptation within the b-cell. Theinsulin secretion rate is higher after oral compared with intravenous glucoseadministration due to the release of glucagon-like peptide-1 (GLP-1)and glucose-dependent insulinotropic polypeptide (GIP) enhancing the glucose-induced insulin secretion (the incretin effect). Our aim was to investigatewhether GIP or GLP-1 release or the incretin effect was different intrained compared with untrained humans after oral and intravenousglucose administration.Methods: A 3½-h oral glucose tolerance test was performed in eleventrained and ten untrained, young, healthy men. On a separate day, an isoglycaemicintravenous glucose infusion was performed matching the individualglucose concentrations obtained during the oral glucose tolerancetest. Blood samples for insulin, C-peptide, GIP and GLP-1 analyses wereobtained frequently during both tests, and the insulin secretion rate, incretineffect and insulin clearance were calculated.Results: Plasma GIP and GLP-1 concentrations, the incretin effect and theinsulin clearance did not differ, and plasma glucose, insulin and C-peptideconcentrations and the insulin secretion rate were lower in trained comparedwith untrained subjects during both tests.Conclusion: With no difference in incretin effect and insulin clearancebetween the two groups, the lower plasma insulin concentrations found intrained compared with untrained, young, healthy men are most likelyexplained by lower b-cell sensitivity to glucose and enhanced glucoseuptake in skeletal muscle in the former group.

KW - Faculty of Health and Medical Sciences

KW - Incretin

KW - insulin

KW - GLP-1

KW - GIP

KW - Exercise

KW - Training

KW - Glucose

U2 - 10.1111/apha.12218

DO - 10.1111/apha.12218

M3 - Journal article

C2 - 24354574

VL - 210

SP - 565

EP - 572

JO - Acta Physiologica

JF - Acta Physiologica

SN - 1748-1708

IS - 3

ER -

ID: 106713600