The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus

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The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus. / Kaur, Simranjeet; Mirza, Aashiq H.; Brorsson, Caroline Anna; Fløyel, Tina; Størling, Joachim; Mortensen, Henrik B.; Pociot, Flemming; Hvidoere International Study Group.

In: Molecular and Cellular Endocrinology, Vol. 419, 05.01.2016, p. 83-91.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kaur, S, Mirza, AH, Brorsson, CA, Fløyel, T, Størling, J, Mortensen, HB, Pociot, F & Hvidoere International Study Group 2016, 'The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus', Molecular and Cellular Endocrinology, vol. 419, pp. 83-91. https://doi.org/10.1016/j.mce.2015.10.002

APA

Kaur, S., Mirza, A. H., Brorsson, C. A., Fløyel, T., Størling, J., Mortensen, H. B., Pociot, F., & Hvidoere International Study Group (2016). The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus. Molecular and Cellular Endocrinology, 419, 83-91. https://doi.org/10.1016/j.mce.2015.10.002

Vancouver

Kaur S, Mirza AH, Brorsson CA, Fløyel T, Størling J, Mortensen HB et al. The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus. Molecular and Cellular Endocrinology. 2016 Jan 5;419:83-91. https://doi.org/10.1016/j.mce.2015.10.002

Author

Kaur, Simranjeet ; Mirza, Aashiq H. ; Brorsson, Caroline Anna ; Fløyel, Tina ; Størling, Joachim ; Mortensen, Henrik B. ; Pociot, Flemming ; Hvidoere International Study Group. / The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus. In: Molecular and Cellular Endocrinology. 2016 ; Vol. 419. pp. 83-91.

Bibtex

@article{d0a3eacdece6477d977160a86b4589b6,

title = "The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus",

abstract = "The study aimed to explore the role of ERBB3 in type 1 diabetes (T1D). We examined whether genetic variation of ERBB3 (rs2292239) affects residual β-cell function in T1D cases. Furthermore, we examined the expression of ERBB3 in human islets, the effect of ERBB3 knockdown on apoptosis in insulin-producing INS-1E cells and the genetic and regulatory architecture of the ERBB3 locus to provide insights to how rs2292239 may confer disease susceptibility. rs2292239 strongly correlated with residual β-cell function and metabolic control in children with T1D. ERBB3 locus associated lncRNA (NONHSAG011351) was found to be expressed in human islets. ERBB3 was expressed and down-regulated by pro-inflammatory cytokines in human islets and INS-1E cells; knockdown of ERBB3 in INS-1E cells decreased basal and cytokine-induced apoptosis. Our data suggests an important functional role of ERBB3 and its potential regulators in the β-cells and may constitute novel targets to prevent β-cell destruction in T1D.",

keywords = "Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",

author = "Simranjeet Kaur and Mirza, {Aashiq H.} and Brorsson, {Caroline Anna} and Tina Fl{\o}yel and Joachim St{\o}rling and Mortensen, {Henrik B.} and Flemming Pociot and {Hvidoere International Study Group}",

year = "2016",

month = jan,

day = "5",

doi = "10.1016/j.mce.2015.10.002",

language = "English",

volume = "419",

pages = "83--91",

journal = "Molecular and Cellular Endocrinology",

issn = "0303-7207",

publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus

AU - Kaur, Simranjeet

AU - Mirza, Aashiq H.

AU - Brorsson, Caroline Anna

AU - Fløyel, Tina

AU - Størling, Joachim

AU - Mortensen, Henrik B.

AU - Pociot, Flemming

AU - Hvidoere International Study Group

PY - 2016/1/5

Y1 - 2016/1/5

N2 - The study aimed to explore the role of ERBB3 in type 1 diabetes (T1D). We examined whether genetic variation of ERBB3 (rs2292239) affects residual β-cell function in T1D cases. Furthermore, we examined the expression of ERBB3 in human islets, the effect of ERBB3 knockdown on apoptosis in insulin-producing INS-1E cells and the genetic and regulatory architecture of the ERBB3 locus to provide insights to how rs2292239 may confer disease susceptibility. rs2292239 strongly correlated with residual β-cell function and metabolic control in children with T1D. ERBB3 locus associated lncRNA (NONHSAG011351) was found to be expressed in human islets. ERBB3 was expressed and down-regulated by pro-inflammatory cytokines in human islets and INS-1E cells; knockdown of ERBB3 in INS-1E cells decreased basal and cytokine-induced apoptosis. Our data suggests an important functional role of ERBB3 and its potential regulators in the β-cells and may constitute novel targets to prevent β-cell destruction in T1D.

AB - The study aimed to explore the role of ERBB3 in type 1 diabetes (T1D). We examined whether genetic variation of ERBB3 (rs2292239) affects residual β-cell function in T1D cases. Furthermore, we examined the expression of ERBB3 in human islets, the effect of ERBB3 knockdown on apoptosis in insulin-producing INS-1E cells and the genetic and regulatory architecture of the ERBB3 locus to provide insights to how rs2292239 may confer disease susceptibility. rs2292239 strongly correlated with residual β-cell function and metabolic control in children with T1D. ERBB3 locus associated lncRNA (NONHSAG011351) was found to be expressed in human islets. ERBB3 was expressed and down-regulated by pro-inflammatory cytokines in human islets and INS-1E cells; knockdown of ERBB3 in INS-1E cells decreased basal and cytokine-induced apoptosis. Our data suggests an important functional role of ERBB3 and its potential regulators in the β-cells and may constitute novel targets to prevent β-cell destruction in T1D.

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.mce.2015.10.002

DO - 10.1016/j.mce.2015.10.002

M3 - Journal article

C2 - 26450151

VL - 419

SP - 83

EP - 91

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

SN - 0303-7207

ER -

ID: 178487913

Department of Biomedical Sciences