The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose

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The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose. / Utzschneider, Kristina M; Tong, Jenny; Montgomery, Brenda; Udayasankar, Jayalakshmi; Gerchman, Fernando; Marcovina, Santica M; Watson, Catherine E; Ligueros-Saylan, Monica A; Foley, James E; Holst, Jens J; Deacon, Carolyn F; Kahn, Steven E.

In: Diabetes Care, Vol. 31, No. 1, 2007, p. 108-113.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Utzschneider, KM, Tong, J, Montgomery, B, Udayasankar, J, Gerchman, F, Marcovina, SM, Watson, CE, Ligueros-Saylan, MA, Foley, JE, Holst, JJ, Deacon, CF & Kahn, SE 2007, 'The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose', Diabetes Care, vol. 31, no. 1, pp. 108-113. https://doi.org/10.2337/dc07-1441

APA

Utzschneider, K. M., Tong, J., Montgomery, B., Udayasankar, J., Gerchman, F., Marcovina, S. M., ... Kahn, S. E. (2007). The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose. Diabetes Care, 31(1), 108-113. https://doi.org/10.2337/dc07-1441

Vancouver

Utzschneider KM, Tong J, Montgomery B, Udayasankar J, Gerchman F, Marcovina SM et al. The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose. Diabetes Care. 2007;31(1):108-113. https://doi.org/10.2337/dc07-1441

Author

Utzschneider, Kristina M ; Tong, Jenny ; Montgomery, Brenda ; Udayasankar, Jayalakshmi ; Gerchman, Fernando ; Marcovina, Santica M ; Watson, Catherine E ; Ligueros-Saylan, Monica A ; Foley, James E ; Holst, Jens J ; Deacon, Carolyn F ; Kahn, Steven E. / The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose. In: Diabetes Care. 2007 ; Vol. 31, No. 1. pp. 108-113.

Bibtex

@article{6545abd0ab4911ddb5e9000ea68e967b,
title = "The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose",
abstract = "OBJECTIVE: To evaluate the effect of treatment with the dipeptidyl peptidase (DPP)-4 inhibitor vildagliptin on insulin sensitivity and beta-cell function in subjects with impaired fasting glucose (IFG). RESEARCH DESIGN AND METHODS: A total of 22 subjects with IFG (11 female and 11 male, mean +/- SD age 59.6 +/- 11.5 years) were treated orally with 100 mg vildagliptin once daily in a single-blind study. Subjects received placebo for 2 weeks (run-in) followed by vildagliptin for 6 weeks (treatment) and then placebo for 2 weeks (washout). A frequently sampled intravenous glucose tolerance test (FSIGT), followed by a 2-h meal tolerance test (MTT), was performed at 2, 8, and 10 weeks. From the FSIGT, the acute insulin response to glucose (AIR(g)) and insulin sensitivity index (S(I)) were determined and used to compute the disposition index (AIR(g) x S(I)) as a measure of beta-cell function. RESULTS: Fasting plasma glucose did not change after 6 weeks of vildagliptin treatment. With treatment, mean +/- SEM AIR(g) increased from 224 +/- 44 to 286 +/- 52 pmol/l (P < 0.05), and S(I) improved from 2.8 +/- 0.5 to 3.5 +/- 0.5 x 10(-5) x min(-1) x pmol(-1) x l (P < 0.01), resulting in an increase in the disposition index from 688 +/- 180 to 1,164 +/- 318 x 10(-5)/min (P < 0.05). These effects were not sustained after washout. During the MTT, the incremental area under the glucose curve was significantly decreased after treatment (240 +/- 15 vs. 191 +/- 14 mmol x l(-1) x min(-1); P = 0.002), but this effect was not sustained after washout. CONCLUSIONS: The DPP-4 inhibitor vildagliptin improves insulin sensitivity and beta-cell function, leading to improved postprandial glycemia in subjects with IFG, who are known to have beta-cell dysfunction. Thus, vildagliptin may prevent progression to diabetes in high-risk subjects.",
author = "Utzschneider, {Kristina M} and Jenny Tong and Brenda Montgomery and Jayalakshmi Udayasankar and Fernando Gerchman and Marcovina, {Santica M} and Watson, {Catherine E} and Ligueros-Saylan, {Monica A} and Foley, {James E} and Holst, {Jens J} and Deacon, {Carolyn F} and Kahn, {Steven E}",
note = "Keywords: Adamantane; Blood Glucose; Dipeptidyl-Peptidase IV Inhibitors; Female; Glucose Intolerance; Humans; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Male; Middle Aged; Nitriles; Placebos; Pyrrolidines; Single-Blind Method",
year = "2007",
doi = "10.2337/dc07-1441",
language = "English",
volume = "31",
pages = "108--113",
journal = "Diabetes Care",
issn = "0149-5992",
publisher = "American Diabetes Association",
number = "1",

}

RIS

TY - JOUR

T1 - The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose

AU - Utzschneider, Kristina M

AU - Tong, Jenny

AU - Montgomery, Brenda

AU - Udayasankar, Jayalakshmi

AU - Gerchman, Fernando

AU - Marcovina, Santica M

AU - Watson, Catherine E

AU - Ligueros-Saylan, Monica A

AU - Foley, James E

AU - Holst, Jens J

AU - Deacon, Carolyn F

AU - Kahn, Steven E

N1 - Keywords: Adamantane; Blood Glucose; Dipeptidyl-Peptidase IV Inhibitors; Female; Glucose Intolerance; Humans; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Male; Middle Aged; Nitriles; Placebos; Pyrrolidines; Single-Blind Method

PY - 2007

Y1 - 2007

N2 - OBJECTIVE: To evaluate the effect of treatment with the dipeptidyl peptidase (DPP)-4 inhibitor vildagliptin on insulin sensitivity and beta-cell function in subjects with impaired fasting glucose (IFG). RESEARCH DESIGN AND METHODS: A total of 22 subjects with IFG (11 female and 11 male, mean +/- SD age 59.6 +/- 11.5 years) were treated orally with 100 mg vildagliptin once daily in a single-blind study. Subjects received placebo for 2 weeks (run-in) followed by vildagliptin for 6 weeks (treatment) and then placebo for 2 weeks (washout). A frequently sampled intravenous glucose tolerance test (FSIGT), followed by a 2-h meal tolerance test (MTT), was performed at 2, 8, and 10 weeks. From the FSIGT, the acute insulin response to glucose (AIR(g)) and insulin sensitivity index (S(I)) were determined and used to compute the disposition index (AIR(g) x S(I)) as a measure of beta-cell function. RESULTS: Fasting plasma glucose did not change after 6 weeks of vildagliptin treatment. With treatment, mean +/- SEM AIR(g) increased from 224 +/- 44 to 286 +/- 52 pmol/l (P < 0.05), and S(I) improved from 2.8 +/- 0.5 to 3.5 +/- 0.5 x 10(-5) x min(-1) x pmol(-1) x l (P < 0.01), resulting in an increase in the disposition index from 688 +/- 180 to 1,164 +/- 318 x 10(-5)/min (P < 0.05). These effects were not sustained after washout. During the MTT, the incremental area under the glucose curve was significantly decreased after treatment (240 +/- 15 vs. 191 +/- 14 mmol x l(-1) x min(-1); P = 0.002), but this effect was not sustained after washout. CONCLUSIONS: The DPP-4 inhibitor vildagliptin improves insulin sensitivity and beta-cell function, leading to improved postprandial glycemia in subjects with IFG, who are known to have beta-cell dysfunction. Thus, vildagliptin may prevent progression to diabetes in high-risk subjects.

AB - OBJECTIVE: To evaluate the effect of treatment with the dipeptidyl peptidase (DPP)-4 inhibitor vildagliptin on insulin sensitivity and beta-cell function in subjects with impaired fasting glucose (IFG). RESEARCH DESIGN AND METHODS: A total of 22 subjects with IFG (11 female and 11 male, mean +/- SD age 59.6 +/- 11.5 years) were treated orally with 100 mg vildagliptin once daily in a single-blind study. Subjects received placebo for 2 weeks (run-in) followed by vildagliptin for 6 weeks (treatment) and then placebo for 2 weeks (washout). A frequently sampled intravenous glucose tolerance test (FSIGT), followed by a 2-h meal tolerance test (MTT), was performed at 2, 8, and 10 weeks. From the FSIGT, the acute insulin response to glucose (AIR(g)) and insulin sensitivity index (S(I)) were determined and used to compute the disposition index (AIR(g) x S(I)) as a measure of beta-cell function. RESULTS: Fasting plasma glucose did not change after 6 weeks of vildagliptin treatment. With treatment, mean +/- SEM AIR(g) increased from 224 +/- 44 to 286 +/- 52 pmol/l (P < 0.05), and S(I) improved from 2.8 +/- 0.5 to 3.5 +/- 0.5 x 10(-5) x min(-1) x pmol(-1) x l (P < 0.01), resulting in an increase in the disposition index from 688 +/- 180 to 1,164 +/- 318 x 10(-5)/min (P < 0.05). These effects were not sustained after washout. During the MTT, the incremental area under the glucose curve was significantly decreased after treatment (240 +/- 15 vs. 191 +/- 14 mmol x l(-1) x min(-1); P = 0.002), but this effect was not sustained after washout. CONCLUSIONS: The DPP-4 inhibitor vildagliptin improves insulin sensitivity and beta-cell function, leading to improved postprandial glycemia in subjects with IFG, who are known to have beta-cell dysfunction. Thus, vildagliptin may prevent progression to diabetes in high-risk subjects.

U2 - 10.2337/dc07-1441

DO - 10.2337/dc07-1441

M3 - Journal article

C2 - 17909087

VL - 31

SP - 108

EP - 113

JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

IS - 1

ER -

ID: 8416890