The antiresorptive effect of GIP, but not GLP-2, is preserved in patients with hypoparathyroidism - a randomized crossover study

Research output: Contribution to journalJournal articlepeer-review

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The antiresorptive effect of GIP, but not GLP-2, is preserved in patients with hypoparathyroidism - a randomized crossover study. / Skov-Jeppesen, Kirsa; Hepp, Nicola; Oeke, Jannika; Hansen, Morten Steen; Jafari, Abbas; Svane, Maria Saur; Balenga, Nariman; Olson, John A; Frost, Morten; Kassem, Moustapha; Madsbad, Sten; Beck Jensen, Jens-Erik; Holst, Jens Juul; Rosenkilde, Mette Marie; Hartmann, Bolette.

In: Journal of Bone and Mineral Research, Vol. 36, No. 8, 2021, p. 1448-1458.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Skov-Jeppesen, K, Hepp, N, Oeke, J, Hansen, MS, Jafari, A, Svane, MS, Balenga, N, Olson, JA, Frost, M, Kassem, M, Madsbad, S, Beck Jensen, J-E, Holst, JJ, Rosenkilde, MM & Hartmann, B 2021, 'The antiresorptive effect of GIP, but not GLP-2, is preserved in patients with hypoparathyroidism - a randomized crossover study', Journal of Bone and Mineral Research, vol. 36, no. 8, pp. 1448-1458. https://doi.org/10.1002/jbmr.4308

APA

Skov-Jeppesen, K., Hepp, N., Oeke, J., Hansen, M. S., Jafari, A., Svane, M. S., Balenga, N., Olson, J. A., Frost, M., Kassem, M., Madsbad, S., Beck Jensen, J-E., Holst, J. J., Rosenkilde, M. M., & Hartmann, B. (2021). The antiresorptive effect of GIP, but not GLP-2, is preserved in patients with hypoparathyroidism - a randomized crossover study. Journal of Bone and Mineral Research, 36(8), 1448-1458. https://doi.org/10.1002/jbmr.4308

Vancouver

Skov-Jeppesen K, Hepp N, Oeke J, Hansen MS, Jafari A, Svane MS et al. The antiresorptive effect of GIP, but not GLP-2, is preserved in patients with hypoparathyroidism - a randomized crossover study. Journal of Bone and Mineral Research. 2021;36(8):1448-1458. https://doi.org/10.1002/jbmr.4308

Author

Skov-Jeppesen, Kirsa ; Hepp, Nicola ; Oeke, Jannika ; Hansen, Morten Steen ; Jafari, Abbas ; Svane, Maria Saur ; Balenga, Nariman ; Olson, John A ; Frost, Morten ; Kassem, Moustapha ; Madsbad, Sten ; Beck Jensen, Jens-Erik ; Holst, Jens Juul ; Rosenkilde, Mette Marie ; Hartmann, Bolette. / The antiresorptive effect of GIP, but not GLP-2, is preserved in patients with hypoparathyroidism - a randomized crossover study. In: Journal of Bone and Mineral Research. 2021 ; Vol. 36, No. 8. pp. 1448-1458.

Bibtex

@article{a997f8c74a2f4176ae757ec027aa20ac,
title = "The antiresorptive effect of GIP, but not GLP-2, is preserved in patients with hypoparathyroidism - a randomized crossover study",
abstract = "Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are gut hormones secreted postprandially. In healthy humans, both hormones decrease bone resorption accompanied by a rapid reduction in parathyroid hormone (PTH). The aim of this study was to investigate whether the changes in bone turnover after meal intake and after GIP- and GLP-2 injections, respectively, are mediated via a reduction in PTH secretion. This was tested in female patients with hypoparathyroidism given a standardized liquid mixed-meal test (n = 7) followed by a peptide injection-test (n = 4) using a randomized crossover design. We observed that the meal- and GIP-, but not the GLP-2-induced changes in bone turnover markers, were preserved in the patients with hypoparathyroidism. To understand the underlying mechanisms, we examined the expression of the GIP receptor (GIPR) and the GLP-2 receptor (GLP-2R) in human osteoblasts and osteoclasts as well as in parathyroid tissue. The GIPR was expressed in both human osteoclasts and osteoblasts, whereas the GLP-2R was absent or only weakly expressed in osteoclasts. Furthermore, both GIPR and GLP-2R were expressed in parathyroid tissue. Our findings suggest that the GIP-induced effect on bone turnover may be mediated directly via GIPR expressed in osteoblasts and osteoclasts and that this may occur independent of PTH. In contrast, the effect of GLP-2 on bone turnover seems to depend on changes in PTH and may be mediated through GLP-2R in the parathyroid gland.",
author = "Kirsa Skov-Jeppesen and Nicola Hepp and Jannika Oeke and Hansen, {Morten Steen} and Abbas Jafari and Svane, {Maria Saur} and Nariman Balenga and Olson, {John A} and Morten Frost and Moustapha Kassem and Sten Madsbad and {Beck Jensen}, Jens-Erik and Holst, {Jens Juul} and Rosenkilde, {Mette Marie} and Bolette Hartmann",
note = "This article is protected by copyright. All rights reserved.",
year = "2021",
doi = "10.1002/jbmr.4308",
language = "English",
volume = "36",
pages = "1448--1458",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "8",

}

RIS

TY - JOUR

T1 - The antiresorptive effect of GIP, but not GLP-2, is preserved in patients with hypoparathyroidism - a randomized crossover study

AU - Skov-Jeppesen, Kirsa

AU - Hepp, Nicola

AU - Oeke, Jannika

AU - Hansen, Morten Steen

AU - Jafari, Abbas

AU - Svane, Maria Saur

AU - Balenga, Nariman

AU - Olson, John A

AU - Frost, Morten

AU - Kassem, Moustapha

AU - Madsbad, Sten

AU - Beck Jensen, Jens-Erik

AU - Holst, Jens Juul

AU - Rosenkilde, Mette Marie

AU - Hartmann, Bolette

N1 - This article is protected by copyright. All rights reserved.

PY - 2021

Y1 - 2021

N2 - Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are gut hormones secreted postprandially. In healthy humans, both hormones decrease bone resorption accompanied by a rapid reduction in parathyroid hormone (PTH). The aim of this study was to investigate whether the changes in bone turnover after meal intake and after GIP- and GLP-2 injections, respectively, are mediated via a reduction in PTH secretion. This was tested in female patients with hypoparathyroidism given a standardized liquid mixed-meal test (n = 7) followed by a peptide injection-test (n = 4) using a randomized crossover design. We observed that the meal- and GIP-, but not the GLP-2-induced changes in bone turnover markers, were preserved in the patients with hypoparathyroidism. To understand the underlying mechanisms, we examined the expression of the GIP receptor (GIPR) and the GLP-2 receptor (GLP-2R) in human osteoblasts and osteoclasts as well as in parathyroid tissue. The GIPR was expressed in both human osteoclasts and osteoblasts, whereas the GLP-2R was absent or only weakly expressed in osteoclasts. Furthermore, both GIPR and GLP-2R were expressed in parathyroid tissue. Our findings suggest that the GIP-induced effect on bone turnover may be mediated directly via GIPR expressed in osteoblasts and osteoclasts and that this may occur independent of PTH. In contrast, the effect of GLP-2 on bone turnover seems to depend on changes in PTH and may be mediated through GLP-2R in the parathyroid gland.

AB - Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are gut hormones secreted postprandially. In healthy humans, both hormones decrease bone resorption accompanied by a rapid reduction in parathyroid hormone (PTH). The aim of this study was to investigate whether the changes in bone turnover after meal intake and after GIP- and GLP-2 injections, respectively, are mediated via a reduction in PTH secretion. This was tested in female patients with hypoparathyroidism given a standardized liquid mixed-meal test (n = 7) followed by a peptide injection-test (n = 4) using a randomized crossover design. We observed that the meal- and GIP-, but not the GLP-2-induced changes in bone turnover markers, were preserved in the patients with hypoparathyroidism. To understand the underlying mechanisms, we examined the expression of the GIP receptor (GIPR) and the GLP-2 receptor (GLP-2R) in human osteoblasts and osteoclasts as well as in parathyroid tissue. The GIPR was expressed in both human osteoclasts and osteoblasts, whereas the GLP-2R was absent or only weakly expressed in osteoclasts. Furthermore, both GIPR and GLP-2R were expressed in parathyroid tissue. Our findings suggest that the GIP-induced effect on bone turnover may be mediated directly via GIPR expressed in osteoblasts and osteoclasts and that this may occur independent of PTH. In contrast, the effect of GLP-2 on bone turnover seems to depend on changes in PTH and may be mediated through GLP-2R in the parathyroid gland.

U2 - 10.1002/jbmr.4308

DO - 10.1002/jbmr.4308

M3 - Journal article

C2 - 33852173

VL - 36

SP - 1448

EP - 1458

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 8

ER -

ID: 260351297