The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial

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The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides : a randomized trial. / Samkani, Amirsalar; Skytte, Mads Gustav Juul; Anholm, Christian; Astrup, Arne; Deacon, Carolyn F; Holst, Jens Juul; Madsbad, Sten; Boston, Ray; Krarup, Thure; Haugaard, Steen B.

In: Lipids in Health and Disease, Vol. 17, 295, 2018.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Samkani, A, Skytte, MGJ, Anholm, C, Astrup, A, Deacon, CF, Holst, JJ, Madsbad, S, Boston, R, Krarup, T & Haugaard, SB 2018, 'The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial', Lipids in Health and Disease, vol. 17, 295. https://doi.org/10.1186/s12944-018-0953-8

APA

Samkani, A., Skytte, M. G. J., Anholm, C., Astrup, A., Deacon, C. F., Holst, J. J., ... Haugaard, S. B. (2018). The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial. Lipids in Health and Disease, 17, [295]. https://doi.org/10.1186/s12944-018-0953-8

Vancouver

Samkani A, Skytte MGJ, Anholm C, Astrup A, Deacon CF, Holst JJ et al. The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial. Lipids in Health and Disease. 2018;17. 295. https://doi.org/10.1186/s12944-018-0953-8

Author

Samkani, Amirsalar ; Skytte, Mads Gustav Juul ; Anholm, Christian ; Astrup, Arne ; Deacon, Carolyn F ; Holst, Jens Juul ; Madsbad, Sten ; Boston, Ray ; Krarup, Thure ; Haugaard, Steen B. / The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides : a randomized trial. In: Lipids in Health and Disease. 2018 ; Vol. 17.

Bibtex

@article{878c00d42cbb4aa99ceab56c053efd31,
title = "The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial",
abstract = "Background: Postprandial non-esterified fatty acid (NEFA) and triglyceride (TG) responses are increased in subjects with type 2 diabetes mellitus (T2DM) and may impair insulin action and increase risk of cardiovascular disease and death. Dietary carbohydrate reduction has been suggested as non-pharmacological therapy for T2DM, but the acute effects on NEFA and TG during subsequent meals remain to be investigated.Methods: Postprandial NEFA and TG responses were assessed in subjects with T2DM by comparing a carbohydrate-reduced high-protein (CRHP) diet with a conventional diabetes (CD) diet in an open-label, randomized, cross-over study. Each diet was consumed on two consecutive days, separated by a wash-out period. The iso-caloric CRHP/CD diets contained 31/54 E{\%} from carbohydrate, 29/16 E{\%} energy from protein and 40/30 E{\%} from fat, respectively. Sixteen subjects with well-controlled T2DM (median HbA1c 47 mmol/mol, (37-67 mmol/mol) and BMI 30 ± 4.4 kg/m2) participated in the study. NEFA and TG were evaluated following breakfast and lunch.Results: NEFA net area under curve (AUC) was increased by 97 ± 38 μmol/Lx270 min (p = 0.024) after breakfast but reduced by 141 ± 33 μmol/Lx180 min (p < 0.001) after lunch on the CRHP compared with CD diet. Likewise, TG net AUC was increased by 80 ± 28 μmol/Lx270 min (p = 0.012) after breakfast but reduced by 320 ± 60 μmol/Lx180 min (p < 0.001) after lunch on the CRHP compared with CD diet.Conclusions: In well-controlled T2DM a modest reduction of dietary carbohydrate with a corresponding increase in protein and fat acutely reduced postprandial serum NEFA suppression and increased serum TG responses after a breakfast meal but had the opposite effect after a lunch meal. The mechanism behind this second-meal phenomenon of CRHP diet on important risk factors for aggravating T2DM and cardiovascular disease awaits further investigation.Trial registration: The study was registered at clinicaltrials.gov ID: NCT02472951. https://clinicaltrials.gov/ct2/show/NCT02472951 . Registered June 16, 2015.",
keywords = "Faculty of Science, Dietary carbohydrate reduction, Postprandial triglycerides, Non-esterified fatty acids",
author = "Amirsalar Samkani and Skytte, {Mads Gustav Juul} and Christian Anholm and Arne Astrup and Deacon, {Carolyn F} and Holst, {Jens Juul} and Sten Madsbad and Ray Boston and Thure Krarup and Haugaard, {Steen B}",
note = "CURIS 2018 NEXS 434",
year = "2018",
doi = "10.1186/s12944-018-0953-8",
language = "English",
volume = "17",
journal = "Lipids in Health and Disease",
issn = "1476-511X",
publisher = "BioMed Central",

}

RIS

TY - JOUR

T1 - The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides

T2 - a randomized trial

AU - Samkani, Amirsalar

AU - Skytte, Mads Gustav Juul

AU - Anholm, Christian

AU - Astrup, Arne

AU - Deacon, Carolyn F

AU - Holst, Jens Juul

AU - Madsbad, Sten

AU - Boston, Ray

AU - Krarup, Thure

AU - Haugaard, Steen B

N1 - CURIS 2018 NEXS 434

PY - 2018

Y1 - 2018

N2 - Background: Postprandial non-esterified fatty acid (NEFA) and triglyceride (TG) responses are increased in subjects with type 2 diabetes mellitus (T2DM) and may impair insulin action and increase risk of cardiovascular disease and death. Dietary carbohydrate reduction has been suggested as non-pharmacological therapy for T2DM, but the acute effects on NEFA and TG during subsequent meals remain to be investigated.Methods: Postprandial NEFA and TG responses were assessed in subjects with T2DM by comparing a carbohydrate-reduced high-protein (CRHP) diet with a conventional diabetes (CD) diet in an open-label, randomized, cross-over study. Each diet was consumed on two consecutive days, separated by a wash-out period. The iso-caloric CRHP/CD diets contained 31/54 E% from carbohydrate, 29/16 E% energy from protein and 40/30 E% from fat, respectively. Sixteen subjects with well-controlled T2DM (median HbA1c 47 mmol/mol, (37-67 mmol/mol) and BMI 30 ± 4.4 kg/m2) participated in the study. NEFA and TG were evaluated following breakfast and lunch.Results: NEFA net area under curve (AUC) was increased by 97 ± 38 μmol/Lx270 min (p = 0.024) after breakfast but reduced by 141 ± 33 μmol/Lx180 min (p < 0.001) after lunch on the CRHP compared with CD diet. Likewise, TG net AUC was increased by 80 ± 28 μmol/Lx270 min (p = 0.012) after breakfast but reduced by 320 ± 60 μmol/Lx180 min (p < 0.001) after lunch on the CRHP compared with CD diet.Conclusions: In well-controlled T2DM a modest reduction of dietary carbohydrate with a corresponding increase in protein and fat acutely reduced postprandial serum NEFA suppression and increased serum TG responses after a breakfast meal but had the opposite effect after a lunch meal. The mechanism behind this second-meal phenomenon of CRHP diet on important risk factors for aggravating T2DM and cardiovascular disease awaits further investigation.Trial registration: The study was registered at clinicaltrials.gov ID: NCT02472951. https://clinicaltrials.gov/ct2/show/NCT02472951 . Registered June 16, 2015.

AB - Background: Postprandial non-esterified fatty acid (NEFA) and triglyceride (TG) responses are increased in subjects with type 2 diabetes mellitus (T2DM) and may impair insulin action and increase risk of cardiovascular disease and death. Dietary carbohydrate reduction has been suggested as non-pharmacological therapy for T2DM, but the acute effects on NEFA and TG during subsequent meals remain to be investigated.Methods: Postprandial NEFA and TG responses were assessed in subjects with T2DM by comparing a carbohydrate-reduced high-protein (CRHP) diet with a conventional diabetes (CD) diet in an open-label, randomized, cross-over study. Each diet was consumed on two consecutive days, separated by a wash-out period. The iso-caloric CRHP/CD diets contained 31/54 E% from carbohydrate, 29/16 E% energy from protein and 40/30 E% from fat, respectively. Sixteen subjects with well-controlled T2DM (median HbA1c 47 mmol/mol, (37-67 mmol/mol) and BMI 30 ± 4.4 kg/m2) participated in the study. NEFA and TG were evaluated following breakfast and lunch.Results: NEFA net area under curve (AUC) was increased by 97 ± 38 μmol/Lx270 min (p = 0.024) after breakfast but reduced by 141 ± 33 μmol/Lx180 min (p < 0.001) after lunch on the CRHP compared with CD diet. Likewise, TG net AUC was increased by 80 ± 28 μmol/Lx270 min (p = 0.012) after breakfast but reduced by 320 ± 60 μmol/Lx180 min (p < 0.001) after lunch on the CRHP compared with CD diet.Conclusions: In well-controlled T2DM a modest reduction of dietary carbohydrate with a corresponding increase in protein and fat acutely reduced postprandial serum NEFA suppression and increased serum TG responses after a breakfast meal but had the opposite effect after a lunch meal. The mechanism behind this second-meal phenomenon of CRHP diet on important risk factors for aggravating T2DM and cardiovascular disease awaits further investigation.Trial registration: The study was registered at clinicaltrials.gov ID: NCT02472951. https://clinicaltrials.gov/ct2/show/NCT02472951 . Registered June 16, 2015.

KW - Faculty of Science

KW - Dietary carbohydrate reduction

KW - Postprandial triglycerides

KW - Non-esterified fatty acids

U2 - 10.1186/s12944-018-0953-8

DO - 10.1186/s12944-018-0953-8

M3 - Journal article

C2 - 30591062

VL - 17

JO - Lipids in Health and Disease

JF - Lipids in Health and Disease

SN - 1476-511X

M1 - 295

ER -

ID: 210787735