Sympathetic vasoconstriction takes an unexpected pannexin detour

Research output: Contribution to journal › Comment/debate › Research › peer-review

Standard

Sympathetic vasoconstriction takes an unexpected pannexin detour. / Schak Nielsen, Morten.

In: Science Signaling, Vol. 8, No. 364, fs4, 17.02.2015, p. 1-2.

Research output: Contribution to journal › Comment/debate › Research › peer-review

Harvard

Schak Nielsen, M 2015, 'Sympathetic vasoconstriction takes an unexpected pannexin detour', Science Signaling, vol. 8, no. 364, fs4, pp. 1-2. https://doi.org/10.1126/scisignal.aaa7312

APA

Schak Nielsen, M. (2015). Sympathetic vasoconstriction takes an unexpected pannexin detour. Science Signaling, 8(364), 1-2. [fs4]. https://doi.org/10.1126/scisignal.aaa7312

Vancouver

Schak Nielsen M. Sympathetic vasoconstriction takes an unexpected pannexin detour. Science Signaling. 2015 Feb 17;8(364):1-2. fs4. https://doi.org/10.1126/scisignal.aaa7312

Author

Schak Nielsen, Morten. / Sympathetic vasoconstriction takes an unexpected pannexin detour. In: Science Signaling. 2015 ; Vol. 8, No. 364. pp. 1-2.

Bibtex

@article{03138ab58686441c94841d8664f717a2,
title = "Sympathetic vasoconstriction takes an unexpected pannexin detour",
abstract = "Sympathetic vasoconstriction plays an important role in the control of blood pressure and the distribution of blood flow. In this issue of Science Signaling, Billaud et al. show that sympathetic vasoconstriction occurs through a complex scheme involving the activation of large-pore pannexin 1 channels and the subsequent release of adenosine triphosphate that promotes contraction in an autocrine and paracrine manner. This elaborate mechanism may function as a point of intercept for other signaling pathways-for example, in relation to the phenomenon {"}functional sympatholysis,{"} in which exercise abrogates sympathetic vasoconstriction in skeletal muscle. Because pannexin 1 channels are inhibited by nitric oxide, they may function as a switch to turn off adrenergic signaling in skeletal muscle during exercise.",
author = "{Schak Nielsen}, Morten",
note = "Copyright {\textcopyright} 2015, American Association for the Advancement of Science.",
year = "2015",
month = feb,
day = "17",
doi = "10.1126/scisignal.aaa7312",
language = "English",
volume = "8",
pages = "1--2",
journal = "Science Signaling",
issn = "1945-0877",
publisher = "American Association for the Advancement of Science",
number = "364",

}

RIS

TY - JOUR

T1 - Sympathetic vasoconstriction takes an unexpected pannexin detour

AU - Schak Nielsen, Morten

N1 - Copyright © 2015, American Association for the Advancement of Science.

PY - 2015/2/17

Y1 - 2015/2/17

N2 - Sympathetic vasoconstriction plays an important role in the control of blood pressure and the distribution of blood flow. In this issue of Science Signaling, Billaud et al. show that sympathetic vasoconstriction occurs through a complex scheme involving the activation of large-pore pannexin 1 channels and the subsequent release of adenosine triphosphate that promotes contraction in an autocrine and paracrine manner. This elaborate mechanism may function as a point of intercept for other signaling pathways-for example, in relation to the phenomenon "functional sympatholysis," in which exercise abrogates sympathetic vasoconstriction in skeletal muscle. Because pannexin 1 channels are inhibited by nitric oxide, they may function as a switch to turn off adrenergic signaling in skeletal muscle during exercise.

AB - Sympathetic vasoconstriction plays an important role in the control of blood pressure and the distribution of blood flow. In this issue of Science Signaling, Billaud et al. show that sympathetic vasoconstriction occurs through a complex scheme involving the activation of large-pore pannexin 1 channels and the subsequent release of adenosine triphosphate that promotes contraction in an autocrine and paracrine manner. This elaborate mechanism may function as a point of intercept for other signaling pathways-for example, in relation to the phenomenon "functional sympatholysis," in which exercise abrogates sympathetic vasoconstriction in skeletal muscle. Because pannexin 1 channels are inhibited by nitric oxide, they may function as a switch to turn off adrenergic signaling in skeletal muscle during exercise.

U2 - 10.1126/scisignal.aaa7312

DO - 10.1126/scisignal.aaa7312

M3 - Comment/debate

C2 - 25690011

VL - 8

SP - 1

EP - 2

JO - Science Signaling

JF - Science Signaling

SN - 1945-0877

IS - 364

M1 - fs4

ER -

ID: 131539236