Rat retinal vasomotion assessed by laser speckle imaging

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Rat retinal vasomotion assessed by laser speckle imaging. / Neganova, Anastasiia Y; Postnov, Dmitry D; Sosnovtseva, Olga; Jacobsen, Jens Christian B.

In: PloS one, Vol. 12, No. 3, e0173805, 2017.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Neganova, AY, Postnov, DD, Sosnovtseva, O & Jacobsen, JCB 2017, 'Rat retinal vasomotion assessed by laser speckle imaging', PloS one, vol. 12, no. 3, e0173805. https://doi.org/10.1371/journal.pone.0173805

APA

Neganova, A. Y., Postnov, D. D., Sosnovtseva, O., & Jacobsen, J. C. B. (2017). Rat retinal vasomotion assessed by laser speckle imaging. PloS one, 12(3), [e0173805]. https://doi.org/10.1371/journal.pone.0173805

Vancouver

Neganova AY, Postnov DD, Sosnovtseva O, Jacobsen JCB. Rat retinal vasomotion assessed by laser speckle imaging. PloS one. 2017;12(3). e0173805. https://doi.org/10.1371/journal.pone.0173805

Author

Neganova, Anastasiia Y ; Postnov, Dmitry D ; Sosnovtseva, Olga ; Jacobsen, Jens Christian B. / Rat retinal vasomotion assessed by laser speckle imaging. In: PloS one. 2017 ; Vol. 12, No. 3.

Bibtex

@article{e69a1b1924b144afb66462f11526ff19,
title = "Rat retinal vasomotion assessed by laser speckle imaging",
abstract = "Vasomotion is spontaneous or induced rhythmic changes in vascular tone or vessel diameter that lead to rhythmic changes in flow. While the vascular research community debates the physiological and pathophysiological consequence of vasomotion, there is a great need for experimental techniques that can address the role and dynamical properties of vasomotion in vivo. We apply laser speckle imaging to study spontaneous and drug induced vasomotion in retinal network of anesthetized rats. The results reveal a wide variety of dynamical patterns. Wavelet-based analysis shows that (i) spontaneous vasomotion occurs in anesthetized animals and (ii) vasomotion can be initiated by systemic administration of the thromboxane analogue U-46619 and the nitric-oxide donor S-nitroso-acetylDL-penicillamine (SNAP). Although these drugs activate different cellular pathways responsible for vasomotion, our approach can track the dynamical changes they cause.",
keywords = "Journal Article",
author = "Neganova, {Anastasiia Y} and Postnov, {Dmitry D} and Olga Sosnovtseva and Jacobsen, {Jens Christian B}",
year = "2017",
doi = "10.1371/journal.pone.0173805",
language = "English",
volume = "12",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

RIS

TY - JOUR

T1 - Rat retinal vasomotion assessed by laser speckle imaging

AU - Neganova, Anastasiia Y

AU - Postnov, Dmitry D

AU - Sosnovtseva, Olga

AU - Jacobsen, Jens Christian B

PY - 2017

Y1 - 2017

N2 - Vasomotion is spontaneous or induced rhythmic changes in vascular tone or vessel diameter that lead to rhythmic changes in flow. While the vascular research community debates the physiological and pathophysiological consequence of vasomotion, there is a great need for experimental techniques that can address the role and dynamical properties of vasomotion in vivo. We apply laser speckle imaging to study spontaneous and drug induced vasomotion in retinal network of anesthetized rats. The results reveal a wide variety of dynamical patterns. Wavelet-based analysis shows that (i) spontaneous vasomotion occurs in anesthetized animals and (ii) vasomotion can be initiated by systemic administration of the thromboxane analogue U-46619 and the nitric-oxide donor S-nitroso-acetylDL-penicillamine (SNAP). Although these drugs activate different cellular pathways responsible for vasomotion, our approach can track the dynamical changes they cause.

AB - Vasomotion is spontaneous or induced rhythmic changes in vascular tone or vessel diameter that lead to rhythmic changes in flow. While the vascular research community debates the physiological and pathophysiological consequence of vasomotion, there is a great need for experimental techniques that can address the role and dynamical properties of vasomotion in vivo. We apply laser speckle imaging to study spontaneous and drug induced vasomotion in retinal network of anesthetized rats. The results reveal a wide variety of dynamical patterns. Wavelet-based analysis shows that (i) spontaneous vasomotion occurs in anesthetized animals and (ii) vasomotion can be initiated by systemic administration of the thromboxane analogue U-46619 and the nitric-oxide donor S-nitroso-acetylDL-penicillamine (SNAP). Although these drugs activate different cellular pathways responsible for vasomotion, our approach can track the dynamical changes they cause.

KW - Journal Article

U2 - 10.1371/journal.pone.0173805

DO - 10.1371/journal.pone.0173805

M3 - Journal article

C2 - 28339503

VL - 12

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 3

M1 - e0173805

ER -

ID: 176771248