Quantitative PET of human urokinase-type plasminogen activator receptor with 64Cu-DOTA-AE105: implications for visualizing cancer invasion
Research output: Contribution to journal › Journal article › Research › peer-review
Expression levels of the urokinase-type plasminogen activator receptor (uPAR) represent an established biomarker for poor prognosis in a variety of human cancers. The objective of the present study was to explore whether noninvasive PET can be used to perform a quantitative assessment of expression levels of uPAR across different human cancer xenograft models in mice and to illustrate the clinical potential of uPAR PET in future settings for individualized therapy.
| Original language | English |
|---|---|
| Journal | Journal of Nuclear Medicine |
| Volume | 53 |
| Issue number | 1 |
| Pages (from-to) | 138-45 |
| Number of pages | 8 |
| ISSN | 0161-5505 |
| DOIs | |
| Publication status | Published - 2012 |
- Animals, Cell Transformation, Neoplastic, Colorectal Neoplasms, Copper Radioisotopes, Female, Gene Expression Regulation, Neoplastic, HT29 Cells, Heterocyclic Compounds, 1-Ring, Humans, Mice, Neoplasm Invasiveness, Oligopeptides, Positron-Emission Tomography, Positron-Emission Tomography and Computed Tomography, Radiochemistry, Receptors, Urokinase Plasminogen Activator
Research areas
ID: 40215604