Quantitative determination of 64Cu-liposome accumulation at inflammatory and infectious sites: Potential for future theranostic system

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Quantitative determination of 64Cu-liposome accumulation at inflammatory and infectious sites : Potential for future theranostic system. / Clausen, Anne Skovsbo; Ostergaard, Daniella Elisabet; Holmberg, Petter; Henriksen, Jonas Rosager; Tham, Johan; Damborg, Peter Panduro; Jensen, Andreas; Kjaer, Andreas; Hansen, Anders Elias; Andresen, Thomas Lars.

In: Journal of Controlled Release, Vol. 327, 2020, p. 737-746.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Clausen, AS, Ostergaard, DE, Holmberg, P, Henriksen, JR, Tham, J, Damborg, PP, Jensen, A, Kjaer, A, Hansen, AE & Andresen, TL 2020, 'Quantitative determination of 64Cu-liposome accumulation at inflammatory and infectious sites: Potential for future theranostic system', Journal of Controlled Release, vol. 327, pp. 737-746. https://doi.org/10.1016/j.jconrel.2020.09.018

APA

Clausen, A. S., Ostergaard, D. E., Holmberg, P., Henriksen, J. R., Tham, J., Damborg, P. P., Jensen, A., Kjaer, A., Hansen, A. E., & Andresen, T. L. (2020). Quantitative determination of 64Cu-liposome accumulation at inflammatory and infectious sites: Potential for future theranostic system. Journal of Controlled Release, 327, 737-746. https://doi.org/10.1016/j.jconrel.2020.09.018

Vancouver

Clausen AS, Ostergaard DE, Holmberg P, Henriksen JR, Tham J, Damborg PP et al. Quantitative determination of 64Cu-liposome accumulation at inflammatory and infectious sites: Potential for future theranostic system. Journal of Controlled Release. 2020;327:737-746. https://doi.org/10.1016/j.jconrel.2020.09.018

Author

Clausen, Anne Skovsbo ; Ostergaard, Daniella Elisabet ; Holmberg, Petter ; Henriksen, Jonas Rosager ; Tham, Johan ; Damborg, Peter Panduro ; Jensen, Andreas ; Kjaer, Andreas ; Hansen, Anders Elias ; Andresen, Thomas Lars. / Quantitative determination of 64Cu-liposome accumulation at inflammatory and infectious sites : Potential for future theranostic system. In: Journal of Controlled Release. 2020 ; Vol. 327. pp. 737-746.

Bibtex

@article{e72b24d03fea4f269075be9549059ab6,
title = "Quantitative determination of 64Cu-liposome accumulation at inflammatory and infectious sites: Potential for future theranostic system",
abstract = "BackgroundTherapeutic interventions for infectious and inflammatory diseases are becoming increasingly challenging in terms of therapeutic resistance and side-effects. Theranostic systems to ameliorate diagnosis and therapy are therefore highly warranted. The pathophysiological changes in inflammatory lesions provide an attractive basis for extravasation and accumulation of PEGylated liposomes. The objective of this study was to provide direct quantitative information on the theranostic potential of radiolabeled liposome for accumulation in inflammatory models using position emission tomography (PET).MethodPreclinical murine models of inflammation (turpentine and LPS), infection (Staphylococcus aureus) and collagen-induced arthritis (CIA) was established and monitored using bioluminescence imaging (BLI). Across all models PET imaging using radiolabeled PEGylated liposomes (64Cu-liposomes) were performed and evaluated in terms of accumulation properties in inflammatory and infectious lesions.ResultsBLI demonstrated that the inflammatory and infectious models were successfully established and provided information on lesion pathology. Activity of 64Cu-liposomes were increased in inflammatory and infectious lesions between early (10-minute or 3-hour) and late (24-hour) PET scans, which validates that a continuous extravasation and accumulation of long circulation PEGylated liposomes occurs.ConclusionThe theranostic potential of long circulating PEGylated radiolabeled liposomes was shown in multiple preclinical models. Impressive accumulation was seen in both inflammatory and infectious lesions. These results are encouraging towards advancing PEGylated liposomes as imaging and drug delivery systems in inflammatory and infectious diseases.",
keywords = "ENHANCED PERMEABILITY, RADIOLABELED LIPOSOMES, MOUSE MODEL, RETENTION, PHARMACOKINETICS, GLUCOCORTICOIDS, OSTEOMYELITIS, NANOPARTICLES, MECHANISMS, ARTHRITIS",
author = "Clausen, {Anne Skovsbo} and Ostergaard, {Daniella Elisabet} and Petter Holmberg and Henriksen, {Jonas Rosager} and Johan Tham and Damborg, {Peter Panduro} and Andreas Jensen and Andreas Kjaer and Hansen, {Anders Elias} and Andresen, {Thomas Lars}",
note = "Corrigendum to {\textquoteleft}quantitative determination of 64Cu-liposome accumulation at inflammatory and infectious sites: Potential for future theranostic system{\textquoteright}: [journal of controlled release 327 (2020) 737–746] Journal of Controlled Release, Volume 330, 10 February 2021, Pages 976 Anne Skovsbo Clausen, Daniella Elisabet {\O}stergaard, Petter Holmberg, Jonas Rosager Henriksen, Johan Tham, Peter Panduro Damborg, Andreas I. Jensen, Andreas Kjaer, Anders Elias Hansen, Thomas Lars Andresen View PDF",
year = "2020",
doi = "10.1016/j.jconrel.2020.09.018",
language = "English",
volume = "327",
pages = "737--746",
journal = "Journal of Controlled Release",
issn = "0168-3659",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Quantitative determination of 64Cu-liposome accumulation at inflammatory and infectious sites

T2 - Potential for future theranostic system

AU - Clausen, Anne Skovsbo

AU - Ostergaard, Daniella Elisabet

AU - Holmberg, Petter

AU - Henriksen, Jonas Rosager

AU - Tham, Johan

AU - Damborg, Peter Panduro

AU - Jensen, Andreas

AU - Kjaer, Andreas

AU - Hansen, Anders Elias

AU - Andresen, Thomas Lars

N1 - Corrigendum to ‘quantitative determination of 64Cu-liposome accumulation at inflammatory and infectious sites: Potential for future theranostic system’: [journal of controlled release 327 (2020) 737–746] Journal of Controlled Release, Volume 330, 10 February 2021, Pages 976 Anne Skovsbo Clausen, Daniella Elisabet Østergaard, Petter Holmberg, Jonas Rosager Henriksen, Johan Tham, Peter Panduro Damborg, Andreas I. Jensen, Andreas Kjaer, Anders Elias Hansen, Thomas Lars Andresen View PDF

PY - 2020

Y1 - 2020

N2 - BackgroundTherapeutic interventions for infectious and inflammatory diseases are becoming increasingly challenging in terms of therapeutic resistance and side-effects. Theranostic systems to ameliorate diagnosis and therapy are therefore highly warranted. The pathophysiological changes in inflammatory lesions provide an attractive basis for extravasation and accumulation of PEGylated liposomes. The objective of this study was to provide direct quantitative information on the theranostic potential of radiolabeled liposome for accumulation in inflammatory models using position emission tomography (PET).MethodPreclinical murine models of inflammation (turpentine and LPS), infection (Staphylococcus aureus) and collagen-induced arthritis (CIA) was established and monitored using bioluminescence imaging (BLI). Across all models PET imaging using radiolabeled PEGylated liposomes (64Cu-liposomes) were performed and evaluated in terms of accumulation properties in inflammatory and infectious lesions.ResultsBLI demonstrated that the inflammatory and infectious models were successfully established and provided information on lesion pathology. Activity of 64Cu-liposomes were increased in inflammatory and infectious lesions between early (10-minute or 3-hour) and late (24-hour) PET scans, which validates that a continuous extravasation and accumulation of long circulation PEGylated liposomes occurs.ConclusionThe theranostic potential of long circulating PEGylated radiolabeled liposomes was shown in multiple preclinical models. Impressive accumulation was seen in both inflammatory and infectious lesions. These results are encouraging towards advancing PEGylated liposomes as imaging and drug delivery systems in inflammatory and infectious diseases.

AB - BackgroundTherapeutic interventions for infectious and inflammatory diseases are becoming increasingly challenging in terms of therapeutic resistance and side-effects. Theranostic systems to ameliorate diagnosis and therapy are therefore highly warranted. The pathophysiological changes in inflammatory lesions provide an attractive basis for extravasation and accumulation of PEGylated liposomes. The objective of this study was to provide direct quantitative information on the theranostic potential of radiolabeled liposome for accumulation in inflammatory models using position emission tomography (PET).MethodPreclinical murine models of inflammation (turpentine and LPS), infection (Staphylococcus aureus) and collagen-induced arthritis (CIA) was established and monitored using bioluminescence imaging (BLI). Across all models PET imaging using radiolabeled PEGylated liposomes (64Cu-liposomes) were performed and evaluated in terms of accumulation properties in inflammatory and infectious lesions.ResultsBLI demonstrated that the inflammatory and infectious models were successfully established and provided information on lesion pathology. Activity of 64Cu-liposomes were increased in inflammatory and infectious lesions between early (10-minute or 3-hour) and late (24-hour) PET scans, which validates that a continuous extravasation and accumulation of long circulation PEGylated liposomes occurs.ConclusionThe theranostic potential of long circulating PEGylated radiolabeled liposomes was shown in multiple preclinical models. Impressive accumulation was seen in both inflammatory and infectious lesions. These results are encouraging towards advancing PEGylated liposomes as imaging and drug delivery systems in inflammatory and infectious diseases.

KW - ENHANCED PERMEABILITY

KW - RADIOLABELED LIPOSOMES

KW - MOUSE MODEL

KW - RETENTION

KW - PHARMACOKINETICS

KW - GLUCOCORTICOIDS

KW - OSTEOMYELITIS

KW - NANOPARTICLES

KW - MECHANISMS

KW - ARTHRITIS

U2 - 10.1016/j.jconrel.2020.09.018

DO - 10.1016/j.jconrel.2020.09.018

M3 - Journal article

C2 - 32920081

AN - SCOPUS:85091195795

VL - 327

SP - 737

EP - 746

JO - Journal of Controlled Release

JF - Journal of Controlled Release

SN - 0168-3659

ER -

ID: 249063679