Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation
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Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation. / Thomsen, Morten Bækgaard; Oros, Avram; Schoenmakers, Marieke; van Opstal, Jurren M; Maas, Joep N; Beekman, Jet D M; Vos, Marc A.
In: Cardiovascular Research, Vol. 73, No. 3, 01.02.2007, p. 521-30.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation
AU - Thomsen, Morten Bækgaard
AU - Oros, Avram
AU - Schoenmakers, Marieke
AU - van Opstal, Jurren M
AU - Maas, Joep N
AU - Beekman, Jet D M
AU - Vos, Marc A
PY - 2007/2/1
Y1 - 2007/2/1
N2 - Acquired long-QT syndrome in combination with increased beat-to-beat variability of repolarisation duration (BVR) is associated with lethal torsades de pointes arrhythmias (TdP) in dogs with remodelled heart after atrioventricular block (AVB). We evaluated the relative contributions of bradycardia and ventricular remodelling to proarrhythmic BVR with and without pharmacological I(Kr) block in order to identify the individual at risk.
AB - Acquired long-QT syndrome in combination with increased beat-to-beat variability of repolarisation duration (BVR) is associated with lethal torsades de pointes arrhythmias (TdP) in dogs with remodelled heart after atrioventricular block (AVB). We evaluated the relative contributions of bradycardia and ventricular remodelling to proarrhythmic BVR with and without pharmacological I(Kr) block in order to identify the individual at risk.
KW - Action Potentials
KW - Acute Disease
KW - Animals
KW - Arrhythmias, Cardiac
KW - Death, Sudden, Cardiac
KW - Dogs
KW - Electrocardiography
KW - Female
KW - Heart Block
KW - Heart Conduction System
KW - Heart Rate
KW - Male
KW - Phenethylamines
KW - Potassium Channel Blockers
KW - Sulfonamides
KW - Torsades de Pointes
KW - Ventricular Remodeling
U2 - 10.1016/j.cardiores.2006.11.025
DO - 10.1016/j.cardiores.2006.11.025
M3 - Journal article
C2 - 17196569
VL - 73
SP - 521
EP - 530
JO - Cardiovascular Research
JF - Cardiovascular Research
SN - 0008-6363
IS - 3
ER -
ID: 45965525