Positron emission tomography/computed tomography for optimized colon cancer staging and follow up

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Positron emission tomography/computed tomography for optimized colon cancer staging and follow up. / Engelmann, Bodil Elisabeth; Loft, Annika; Kjær, Andreas; Nielsen, Hans Jørgen; Berthelsen, Anne Kiil; Binderup, Tina; Brinch, Kim; Brünner, Nils; Gerds, Thomas Alexander; Høyer-Hansen, Gunilla; Kristensen, Michael Holmsgaard; Kurt, Engin Yeter; Latocha, Jan Erik; Lindblom, Gunnar; Sloth, Carsten; Højgaard, Liselotte.

In: Scandinavian Journal of Gastroenterology, Vol. 49, No. 2, 02.2014, p. 191-201.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Engelmann, BE, Loft, A, Kjær, A, Nielsen, HJ, Berthelsen, AK, Binderup, T, Brinch, K, Brünner, N, Gerds, TA, Høyer-Hansen, G, Kristensen, MH, Kurt, EY, Latocha, JE, Lindblom, G, Sloth, C & Højgaard, L 2014, 'Positron emission tomography/computed tomography for optimized colon cancer staging and follow up', Scandinavian Journal of Gastroenterology, vol. 49, no. 2, pp. 191-201. https://doi.org/10.3109/00365521.2013.863967

APA

Engelmann, B. E., Loft, A., Kjær, A., Nielsen, H. J., Berthelsen, A. K., Binderup, T., ... Højgaard, L. (2014). Positron emission tomography/computed tomography for optimized colon cancer staging and follow up. Scandinavian Journal of Gastroenterology, 49(2), 191-201. https://doi.org/10.3109/00365521.2013.863967

Vancouver

Engelmann BE, Loft A, Kjær A, Nielsen HJ, Berthelsen AK, Binderup T et al. Positron emission tomography/computed tomography for optimized colon cancer staging and follow up. Scandinavian Journal of Gastroenterology. 2014 Feb;49(2):191-201. https://doi.org/10.3109/00365521.2013.863967

Author

Engelmann, Bodil Elisabeth ; Loft, Annika ; Kjær, Andreas ; Nielsen, Hans Jørgen ; Berthelsen, Anne Kiil ; Binderup, Tina ; Brinch, Kim ; Brünner, Nils ; Gerds, Thomas Alexander ; Høyer-Hansen, Gunilla ; Kristensen, Michael Holmsgaard ; Kurt, Engin Yeter ; Latocha, Jan Erik ; Lindblom, Gunnar ; Sloth, Carsten ; Højgaard, Liselotte. / Positron emission tomography/computed tomography for optimized colon cancer staging and follow up. In: Scandinavian Journal of Gastroenterology. 2014 ; Vol. 49, No. 2. pp. 191-201.

Bibtex

@article{a4d0db1520ad4ab1bd17d9ea5179f0bf,
title = "Positron emission tomography/computed tomography for optimized colon cancer staging and follow up",
abstract = "OBJECTIVES: Optimal management of colon cancer (CC) requires detailed assessment of extent of disease. This study prospectively investigates the diagnostic accuracy of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (PET/CT) for staging and detection of recurrence in primary CC.MATERIAL AND METHODS: PET/CT for preoperative staging was performed in 66 prospectively included patients with primary CC. Diagnostic accuracy for PET/CT and CT was analyzed. In addition to routine follow up, 42 stages I-III CC patients had postoperative PET/CT examinations every 6 months for 2 years. Serological levels of tissue inhibitor of metalloproteinase-1 (TIMP-1), carcinoembryonic antigen, and liberated domain I of urokinase plasminogen activator receptor were analyzed.RESULTS: Accuracy for tumor, nodal, and metastases staging by PET/CT were 82{\%} (95{\%} confidence interval [CI]: 70; 91), 66{\%} (CI: 51; 78), and 89{\%} (CI: 79; 96); for CT the accuracy was 77{\%} (CI: 64; 87), 60{\%} (CI: 46; 73), and 69{\%} (CI: 57; 80). Cumulative relapse incidences for stages I-III CC at 6, 12, 18, and 24 months were 7.1{\%} (CI: 0; 15); 14.3{\%} (CI: 4; 25); 19{\%} (CI: 7; 31), and 21.4{\%} (CI: 9; 34). PET/CT diagnosed all relapses detected during the first 2 years. High preoperative TIMP-1 levels were associated with significant hazards toward risk of recurrence and shorter overall survival.CONCLUSIONS: This study indicates PET/CT as a valuable tool for staging and follow up in CC. TIMP-1 provided prognostic information potentially useful in selection of patients for intensive follow up.",
author = "Engelmann, {Bodil Elisabeth} and Annika Loft and Andreas Kj{\ae}r and Nielsen, {Hans J{\o}rgen} and Berthelsen, {Anne Kiil} and Tina Binderup and Kim Brinch and Nils Br{\"u}nner and Gerds, {Thomas Alexander} and Gunilla H{\o}yer-Hansen and Kristensen, {Michael Holmsgaard} and Kurt, {Engin Yeter} and Latocha, {Jan Erik} and Gunnar Lindblom and Carsten Sloth and Liselotte H{\o}jgaard",
year = "2014",
month = "2",
doi = "10.3109/00365521.2013.863967",
language = "English",
volume = "49",
pages = "191--201",
journal = "Scandinavian Journal of Gastroenterology. Supplement",
issn = "0085-5928",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - Positron emission tomography/computed tomography for optimized colon cancer staging and follow up

AU - Engelmann, Bodil Elisabeth

AU - Loft, Annika

AU - Kjær, Andreas

AU - Nielsen, Hans Jørgen

AU - Berthelsen, Anne Kiil

AU - Binderup, Tina

AU - Brinch, Kim

AU - Brünner, Nils

AU - Gerds, Thomas Alexander

AU - Høyer-Hansen, Gunilla

AU - Kristensen, Michael Holmsgaard

AU - Kurt, Engin Yeter

AU - Latocha, Jan Erik

AU - Lindblom, Gunnar

AU - Sloth, Carsten

AU - Højgaard, Liselotte

PY - 2014/2

Y1 - 2014/2

N2 - OBJECTIVES: Optimal management of colon cancer (CC) requires detailed assessment of extent of disease. This study prospectively investigates the diagnostic accuracy of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (PET/CT) for staging and detection of recurrence in primary CC.MATERIAL AND METHODS: PET/CT for preoperative staging was performed in 66 prospectively included patients with primary CC. Diagnostic accuracy for PET/CT and CT was analyzed. In addition to routine follow up, 42 stages I-III CC patients had postoperative PET/CT examinations every 6 months for 2 years. Serological levels of tissue inhibitor of metalloproteinase-1 (TIMP-1), carcinoembryonic antigen, and liberated domain I of urokinase plasminogen activator receptor were analyzed.RESULTS: Accuracy for tumor, nodal, and metastases staging by PET/CT were 82% (95% confidence interval [CI]: 70; 91), 66% (CI: 51; 78), and 89% (CI: 79; 96); for CT the accuracy was 77% (CI: 64; 87), 60% (CI: 46; 73), and 69% (CI: 57; 80). Cumulative relapse incidences for stages I-III CC at 6, 12, 18, and 24 months were 7.1% (CI: 0; 15); 14.3% (CI: 4; 25); 19% (CI: 7; 31), and 21.4% (CI: 9; 34). PET/CT diagnosed all relapses detected during the first 2 years. High preoperative TIMP-1 levels were associated with significant hazards toward risk of recurrence and shorter overall survival.CONCLUSIONS: This study indicates PET/CT as a valuable tool for staging and follow up in CC. TIMP-1 provided prognostic information potentially useful in selection of patients for intensive follow up.

AB - OBJECTIVES: Optimal management of colon cancer (CC) requires detailed assessment of extent of disease. This study prospectively investigates the diagnostic accuracy of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (PET/CT) for staging and detection of recurrence in primary CC.MATERIAL AND METHODS: PET/CT for preoperative staging was performed in 66 prospectively included patients with primary CC. Diagnostic accuracy for PET/CT and CT was analyzed. In addition to routine follow up, 42 stages I-III CC patients had postoperative PET/CT examinations every 6 months for 2 years. Serological levels of tissue inhibitor of metalloproteinase-1 (TIMP-1), carcinoembryonic antigen, and liberated domain I of urokinase plasminogen activator receptor were analyzed.RESULTS: Accuracy for tumor, nodal, and metastases staging by PET/CT were 82% (95% confidence interval [CI]: 70; 91), 66% (CI: 51; 78), and 89% (CI: 79; 96); for CT the accuracy was 77% (CI: 64; 87), 60% (CI: 46; 73), and 69% (CI: 57; 80). Cumulative relapse incidences for stages I-III CC at 6, 12, 18, and 24 months were 7.1% (CI: 0; 15); 14.3% (CI: 4; 25); 19% (CI: 7; 31), and 21.4% (CI: 9; 34). PET/CT diagnosed all relapses detected during the first 2 years. High preoperative TIMP-1 levels were associated with significant hazards toward risk of recurrence and shorter overall survival.CONCLUSIONS: This study indicates PET/CT as a valuable tool for staging and follow up in CC. TIMP-1 provided prognostic information potentially useful in selection of patients for intensive follow up.

U2 - 10.3109/00365521.2013.863967

DO - 10.3109/00365521.2013.863967

M3 - Journal article

C2 - 24286594

VL - 49

SP - 191

EP - 201

JO - Scandinavian Journal of Gastroenterology. Supplement

JF - Scandinavian Journal of Gastroenterology. Supplement

SN - 0085-5928

IS - 2

ER -

ID: 120330399