Physiological role of taurine - from organism to organelle

Research output: Contribution to journal › Review › Research › peer-review

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Physiological role of taurine - from organism to organelle. / Lambert, Ian Henry; Kristensen, David Møbjerg Boslev; Holm, Jacob Bak; Mortensen, Ole Hartvig.

In: Acta Physiologica (Print), Vol. 213, No. 1, 2015, p. 191-212.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Lambert, IH, Kristensen, DMB, Holm, JB & Mortensen, OH 2015, 'Physiological role of taurine - from organism to organelle', Acta Physiologica (Print), vol. 213, no. 1, pp. 191-212. https://doi.org/10.1111/apha.12365

APA

Lambert, I. H., Kristensen, D. M. B., Holm, J. B., & Mortensen, O. H. (2015). Physiological role of taurine - from organism to organelle. Acta Physiologica (Print), 213(1), 191-212. https://doi.org/10.1111/apha.12365

Vancouver

Lambert IH, Kristensen DMB, Holm JB, Mortensen OH. Physiological role of taurine - from organism to organelle. Acta Physiologica (Print). 2015;213(1):191-212. https://doi.org/10.1111/apha.12365

Author

Lambert, Ian Henry ; Kristensen, David Møbjerg Boslev ; Holm, Jacob Bak ; Mortensen, Ole Hartvig. / Physiological role of taurine - from organism to organelle. In: Acta Physiologica (Print). 2015 ; Vol. 213, No. 1. pp. 191-212.

Bibtex

@article{de663a31e98a4d6dbf6f231d39893268,

title = "Physiological role of taurine - from organism to organelle",

abstract = "Taurine is often referred to as a semi-essential amino acid as newborn mammals have a limited ability to synthesize taurine and have to rely on dietary supply. Taurine is not thought to be incorporated into proteins as no aminoacyl tRNA synthetase has yet been identified and is not oxidized in mammalian cells. However, taurine contributes significantly to the cellular pool of organic osmolytes and has accordingly been acknowledged for its role in cell volume restoration following osmotic perturbation. This review describes taurine homeostasis in cells and organelles with emphasis on taurine biophysics/membrane dynamics, regulation of transport proteins involved in active taurine uptake and passive taurine release as well as physiological processes, for example, development, lung function, mitochondrial function, antioxidative defence and apoptosis which seem to be affected by a shift in the expression of the taurine transporters and/or the cellular taurine content.",

author = "Lambert, {Ian Henry} and Kristensen, {David M{\o}bjerg Boslev} and Holm, {Jacob Bak} and Mortensen, {Ole Hartvig}",

note = "{\textcopyright} 2014 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.",

year = "2015",

doi = "10.1111/apha.12365",

language = "English",

volume = "213",

pages = "191--212",

journal = "Acta Physiologica",

issn = "1748-1708",

publisher = "Wiley-Blackwell",

number = "1",

}

RIS

TY - JOUR

T1 - Physiological role of taurine - from organism to organelle

AU - Lambert, Ian Henry

AU - Kristensen, David Møbjerg Boslev

AU - Holm, Jacob Bak

AU - Mortensen, Ole Hartvig

PY - 2015

Y1 - 2015

N2 - Taurine is often referred to as a semi-essential amino acid as newborn mammals have a limited ability to synthesize taurine and have to rely on dietary supply. Taurine is not thought to be incorporated into proteins as no aminoacyl tRNA synthetase has yet been identified and is not oxidized in mammalian cells. However, taurine contributes significantly to the cellular pool of organic osmolytes and has accordingly been acknowledged for its role in cell volume restoration following osmotic perturbation. This review describes taurine homeostasis in cells and organelles with emphasis on taurine biophysics/membrane dynamics, regulation of transport proteins involved in active taurine uptake and passive taurine release as well as physiological processes, for example, development, lung function, mitochondrial function, antioxidative defence and apoptosis which seem to be affected by a shift in the expression of the taurine transporters and/or the cellular taurine content.

AB - Taurine is often referred to as a semi-essential amino acid as newborn mammals have a limited ability to synthesize taurine and have to rely on dietary supply. Taurine is not thought to be incorporated into proteins as no aminoacyl tRNA synthetase has yet been identified and is not oxidized in mammalian cells. However, taurine contributes significantly to the cellular pool of organic osmolytes and has accordingly been acknowledged for its role in cell volume restoration following osmotic perturbation. This review describes taurine homeostasis in cells and organelles with emphasis on taurine biophysics/membrane dynamics, regulation of transport proteins involved in active taurine uptake and passive taurine release as well as physiological processes, for example, development, lung function, mitochondrial function, antioxidative defence and apoptosis which seem to be affected by a shift in the expression of the taurine transporters and/or the cellular taurine content.

U2 - 10.1111/apha.12365

DO - 10.1111/apha.12365

M3 - Review

C2 - 25142161

VL - 213

SP - 191

EP - 212

JO - Acta Physiologica

JF - Acta Physiologica

SN - 1748-1708

IS - 1

ER -

ID: 123943836

Department of Biomedical Sciences