Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety. / Schmidt, P T; Näslund, E; Grybäck, P; Jacobsson, H; Hartmann, B; Holst, Jens Juul; Hellström, P M.

In: Regulatory Peptides, Vol. 116, No. 1-3, 15.11.2003, p. 21-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Schmidt, PT, Näslund, E, Grybäck, P, Jacobsson, H, Hartmann, B, Holst, JJ & Hellström, PM 2003, 'Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety', Regulatory Peptides, vol. 116, no. 1-3, pp. 21-5.

APA

Schmidt, P. T., Näslund, E., Grybäck, P., Jacobsson, H., Hartmann, B., Holst, J. J., & Hellström, P. M. (2003). Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety. Regulatory Peptides, 116(1-3), 21-5.

Vancouver

Schmidt PT, Näslund E, Grybäck P, Jacobsson H, Hartmann B, Holst JJ et al. Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety. Regulatory Peptides. 2003 Nov 15;116(1-3):21-5.

Author

Schmidt, P T ; Näslund, E ; Grybäck, P ; Jacobsson, H ; Hartmann, B ; Holst, Jens Juul ; Hellström, P M. / Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety. In: Regulatory Peptides. 2003 ; Vol. 116, No. 1-3. pp. 21-5.

Bibtex

@article{10c0f09c9f494939914715f2d55d760a,
title = "Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety",
abstract = "Glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) are secreted in parallel to the circulation after a meal. Intravenous (IV) GLP-1 has an inhibitory effect on gastric emptying, hunger and food intake in man. In rodents, central administration of GLP-2 increases satiety similar to GLP-1. The aim of the present study was to assess the effect of IV administered GLP-2 on gastric emptying and feelings of hunger in human volunteers. In eight (five men) healthy subjects (age 31.1+/-2.9 years and BMI 24.1+/-1.0 kg m(-2)), scintigraphic solid gastric emptying, hunger ratings (VAS) and plasma concentrations of GLP-2 were studied during infusion of saline or GLP-2 (0.75 and 2.25 pmol kg(-1) min(-1)) for a total of 180 min. Concentrations of GLP-2 were elevated to a maximum of 50 and 110 pmol l(-1) for 0.75 and 2.25 pmol kg(-1) min(-1) infusion of GLP-2, respectively. There was no effect of GLP-2 on either the lag phase (29.5+/-4.4, 26.0+/-5.2 and 21.2+/-3.6 min for saline, GLP-2 0.75 or 2.25 pmol kg(-1) min(-1), respectively) or the half emptying time (84.5+/-6.1, 89.5+/-17.8 and 85.0+/-7.0 min for saline, GLP-2 0.75 or 2.25 pmol kg(-1) min(-1), respectively). The change in hunger rating after the meal to 180 min was also unaffected by infusion of GLP-2. GLP-2 does not seem to mediate the ileal brake mechanism.",
keywords = "Adult, Appetite Regulation, Cross-Over Studies, Gastric Emptying, Glucagon-Like Peptide 1, Glucagon-Like Peptide 2, Humans, Infusions, Intravenous, Male, Peptides, Satiation",
author = "Schmidt, {P T} and E N{\"a}slund and P Gryb{\"a}ck and H Jacobsson and B Hartmann and Holst, {Jens Juul} and Hellstr{\"o}m, {P M}",
year = "2003",
month = nov,
day = "15",
language = "English",
volume = "116",
pages = "21--5",
journal = "Regulatory Peptides",
issn = "0167-0115",
publisher = "Elsevier",
number = "1-3",

}

RIS

TY - JOUR

T1 - Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety

AU - Schmidt, P T

AU - Näslund, E

AU - Grybäck, P

AU - Jacobsson, H

AU - Hartmann, B

AU - Holst, Jens Juul

AU - Hellström, P M

PY - 2003/11/15

Y1 - 2003/11/15

N2 - Glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) are secreted in parallel to the circulation after a meal. Intravenous (IV) GLP-1 has an inhibitory effect on gastric emptying, hunger and food intake in man. In rodents, central administration of GLP-2 increases satiety similar to GLP-1. The aim of the present study was to assess the effect of IV administered GLP-2 on gastric emptying and feelings of hunger in human volunteers. In eight (five men) healthy subjects (age 31.1+/-2.9 years and BMI 24.1+/-1.0 kg m(-2)), scintigraphic solid gastric emptying, hunger ratings (VAS) and plasma concentrations of GLP-2 were studied during infusion of saline or GLP-2 (0.75 and 2.25 pmol kg(-1) min(-1)) for a total of 180 min. Concentrations of GLP-2 were elevated to a maximum of 50 and 110 pmol l(-1) for 0.75 and 2.25 pmol kg(-1) min(-1) infusion of GLP-2, respectively. There was no effect of GLP-2 on either the lag phase (29.5+/-4.4, 26.0+/-5.2 and 21.2+/-3.6 min for saline, GLP-2 0.75 or 2.25 pmol kg(-1) min(-1), respectively) or the half emptying time (84.5+/-6.1, 89.5+/-17.8 and 85.0+/-7.0 min for saline, GLP-2 0.75 or 2.25 pmol kg(-1) min(-1), respectively). The change in hunger rating after the meal to 180 min was also unaffected by infusion of GLP-2. GLP-2 does not seem to mediate the ileal brake mechanism.

AB - Glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) are secreted in parallel to the circulation after a meal. Intravenous (IV) GLP-1 has an inhibitory effect on gastric emptying, hunger and food intake in man. In rodents, central administration of GLP-2 increases satiety similar to GLP-1. The aim of the present study was to assess the effect of IV administered GLP-2 on gastric emptying and feelings of hunger in human volunteers. In eight (five men) healthy subjects (age 31.1+/-2.9 years and BMI 24.1+/-1.0 kg m(-2)), scintigraphic solid gastric emptying, hunger ratings (VAS) and plasma concentrations of GLP-2 were studied during infusion of saline or GLP-2 (0.75 and 2.25 pmol kg(-1) min(-1)) for a total of 180 min. Concentrations of GLP-2 were elevated to a maximum of 50 and 110 pmol l(-1) for 0.75 and 2.25 pmol kg(-1) min(-1) infusion of GLP-2, respectively. There was no effect of GLP-2 on either the lag phase (29.5+/-4.4, 26.0+/-5.2 and 21.2+/-3.6 min for saline, GLP-2 0.75 or 2.25 pmol kg(-1) min(-1), respectively) or the half emptying time (84.5+/-6.1, 89.5+/-17.8 and 85.0+/-7.0 min for saline, GLP-2 0.75 or 2.25 pmol kg(-1) min(-1), respectively). The change in hunger rating after the meal to 180 min was also unaffected by infusion of GLP-2. GLP-2 does not seem to mediate the ileal brake mechanism.

KW - Adult

KW - Appetite Regulation

KW - Cross-Over Studies

KW - Gastric Emptying

KW - Glucagon-Like Peptide 1

KW - Glucagon-Like Peptide 2

KW - Humans

KW - Infusions, Intravenous

KW - Male

KW - Peptides

KW - Satiation

M3 - Journal article

C2 - 14599711

VL - 116

SP - 21

EP - 25

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

IS - 1-3

ER -

ID: 132054947