Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome

Research output: Contribution to journalJournal articlepeer-review

  • Alon Barsheshet
  • Ilan Goldenberg
  • Jin O-Uchi
  • Arthur J Moss
  • Christian Jons
  • Wataru Shimizu
  • Arthur A Wilde
  • Scott McNitt
  • Derick R Peterson
  • Wojciech Zareba
  • Jennifer L Robinson
  • Michael J Ackerman
  • Michael Cypress
  • Daniel A Gray
  • Nynke Hofman
  • Elizabeth S Kaufman
  • Pyotr G Platonov
  • Ming Qi
  • Jeffrey A Towbin
  • G Michael Vincent
  • Coeli M Lopes
β-Adrenergic stimulation is the main trigger for cardiac events in type 1 long-QT syndrome (LQT1). We evaluated a possible association between ion channel response to β-adrenergic stimulation and clinical response to β-blocker therapy according to mutation location.
Original languageEnglish
JournalCirculation
Volume125
Issue number16
Pages (from-to)1988-96
Number of pages9
ISSN0009-7322
DOIs
Publication statusPublished - 24 Apr 2012

    Research areas

  • Adolescent, Adrenergic beta-Antagonists, Adult, Child, Female, Genetic Predisposition to Disease, Heart Arrest, Humans, KCNQ1 Potassium Channel, Male, Mutation, Risk, Romano-Ward Syndrome, Treatment Outcome, Young Adult

ID: 48052006