Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients

Research output: Contribution to journal › Journal article › Research › peer-review

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Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients. / Shirakawa, Ryosuke; Yokota, Takashi; Nakajima, Takayuki; Takada, Shingo; Yamane, Miwako; Furihata, Takaaki; Maekawa, Satoshi; Nambu, Hideo; Katayama, Takashi; Fukushima, Arata; Saito, Akimichi; Ishimori, Naoki; Dela, Flemming; Kinugawa, Shintaro; Anzai, Toshihisa.

In: Scientific Reports, Vol. 9, 14709, 2019.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Shirakawa, R, Yokota, T, Nakajima, T, Takada, S, Yamane, M, Furihata, T, Maekawa, S, Nambu, H, Katayama, T, Fukushima, A, Saito, A, Ishimori, N, Dela, F, Kinugawa, S & Anzai, T 2019, 'Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients', Scientific Reports, vol. 9, 14709. https://doi.org/10.1038/s41598-019-51298-3

APA

Shirakawa, R., Yokota, T., Nakajima, T., Takada, S., Yamane, M., Furihata, T., Maekawa, S., Nambu, H., Katayama, T., Fukushima, A., Saito, A., Ishimori, N., Dela, F., Kinugawa, S., & Anzai, T. (2019). Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients. Scientific Reports, 9, [14709]. https://doi.org/10.1038/s41598-019-51298-3

Vancouver

Shirakawa R, Yokota T, Nakajima T, Takada S, Yamane M, Furihata T et al. Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients. Scientific Reports. 2019;9. 14709. https://doi.org/10.1038/s41598-019-51298-3

Author

Shirakawa, Ryosuke ; Yokota, Takashi ; Nakajima, Takayuki ; Takada, Shingo ; Yamane, Miwako ; Furihata, Takaaki ; Maekawa, Satoshi ; Nambu, Hideo ; Katayama, Takashi ; Fukushima, Arata ; Saito, Akimichi ; Ishimori, Naoki ; Dela, Flemming ; Kinugawa, Shintaro ; Anzai, Toshihisa. / Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients. In: Scientific Reports. 2019 ; Vol. 9.

Bibtex

@article{4bfb0cd766ed4e7cb3f5bc02304be55c,
title = "Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients",
abstract = "Systemic oxidative stress plays a key role in the development of chronic heart failure (CHF). We tested the hypothesis that mitochondrial reactive oxygen species (ROS) generation in circulating peripheral blood mononuclear cells (PBMCs) contributes to CHF progression. A total of 31 patients who had a history of hospital admission due to worsening HF were enrolled and grouped as having either mild CHF defined as NewYork Heart Association (NYHA) functional class I-II or moderate-to-severe CHF defined as NYHA functional class III. ROS levels in PBMC mitochondria were significantly increased in CHF patients with NYHA functional class III compared to those with NYHA functional class I-II, accompanied by impaired mitochondrial respiratory capacity in PBMCs. ROS generation in PBMC mitochondria was positively correlated with urinary 8-hydroxydeoxyguanosine, a systemic oxidative stress marker, in CHF patients. Importantly, mitochondrial ROS generation in PBMCs was directly correlated with plasma levels of B-type natriuretic peptide, a biomarker for severity of HF, and inversely correlated with peak oxygen uptake, a parameter of exercise capacity, in CHF patients. The study showed that ROS generation in PBMC mitochondria was higher in patients with advanced CHF, and it was associated with disease severity and exercise intolerance in CHF patients.",
author = "Ryosuke Shirakawa and Takashi Yokota and Takayuki Nakajima and Shingo Takada and Miwako Yamane and Takaaki Furihata and Satoshi Maekawa and Hideo Nambu and Takashi Katayama and Arata Fukushima and Akimichi Saito and Naoki Ishimori and Flemming Dela and Shintaro Kinugawa and Toshihisa Anzai",
year = "2019",
doi = "10.1038/s41598-019-51298-3",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients

AU - Shirakawa, Ryosuke

AU - Yokota, Takashi

AU - Nakajima, Takayuki

AU - Takada, Shingo

AU - Yamane, Miwako

AU - Furihata, Takaaki

AU - Maekawa, Satoshi

AU - Nambu, Hideo

AU - Katayama, Takashi

AU - Fukushima, Arata

AU - Saito, Akimichi

AU - Ishimori, Naoki

AU - Dela, Flemming

AU - Kinugawa, Shintaro

AU - Anzai, Toshihisa

PY - 2019

Y1 - 2019

N2 - Systemic oxidative stress plays a key role in the development of chronic heart failure (CHF). We tested the hypothesis that mitochondrial reactive oxygen species (ROS) generation in circulating peripheral blood mononuclear cells (PBMCs) contributes to CHF progression. A total of 31 patients who had a history of hospital admission due to worsening HF were enrolled and grouped as having either mild CHF defined as NewYork Heart Association (NYHA) functional class I-II or moderate-to-severe CHF defined as NYHA functional class III. ROS levels in PBMC mitochondria were significantly increased in CHF patients with NYHA functional class III compared to those with NYHA functional class I-II, accompanied by impaired mitochondrial respiratory capacity in PBMCs. ROS generation in PBMC mitochondria was positively correlated with urinary 8-hydroxydeoxyguanosine, a systemic oxidative stress marker, in CHF patients. Importantly, mitochondrial ROS generation in PBMCs was directly correlated with plasma levels of B-type natriuretic peptide, a biomarker for severity of HF, and inversely correlated with peak oxygen uptake, a parameter of exercise capacity, in CHF patients. The study showed that ROS generation in PBMC mitochondria was higher in patients with advanced CHF, and it was associated with disease severity and exercise intolerance in CHF patients.

AB - Systemic oxidative stress plays a key role in the development of chronic heart failure (CHF). We tested the hypothesis that mitochondrial reactive oxygen species (ROS) generation in circulating peripheral blood mononuclear cells (PBMCs) contributes to CHF progression. A total of 31 patients who had a history of hospital admission due to worsening HF were enrolled and grouped as having either mild CHF defined as NewYork Heart Association (NYHA) functional class I-II or moderate-to-severe CHF defined as NYHA functional class III. ROS levels in PBMC mitochondria were significantly increased in CHF patients with NYHA functional class III compared to those with NYHA functional class I-II, accompanied by impaired mitochondrial respiratory capacity in PBMCs. ROS generation in PBMC mitochondria was positively correlated with urinary 8-hydroxydeoxyguanosine, a systemic oxidative stress marker, in CHF patients. Importantly, mitochondrial ROS generation in PBMCs was directly correlated with plasma levels of B-type natriuretic peptide, a biomarker for severity of HF, and inversely correlated with peak oxygen uptake, a parameter of exercise capacity, in CHF patients. The study showed that ROS generation in PBMC mitochondria was higher in patients with advanced CHF, and it was associated with disease severity and exercise intolerance in CHF patients.

U2 - 10.1038/s41598-019-51298-3

DO - 10.1038/s41598-019-51298-3

M3 - Journal article

C2 - 31605012

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 14709

ER -

ID: 229060005