Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men

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Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men. / Matikainen, Niina; Björnson, Elias; Söderlund, Sanni; Borén, Christofer; Eliasson, Björn; Pietiläinen, Kirsi H; Bogl, Leonie H; Hakkarainen, Antti; Lundbom, Nina; Rivellese, Angela; Riccardi, Gabriele; Després, Jean-Pierre; Alméras, Natalie; Holst, Jens Juul; Deacon, Carolyn F; Borén, Jan; Taskinen, Marja-Riitta.

In: PLOS ONE, Vol. 11, No. 1, e0145890, 2016, p. 1-15.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Matikainen, N, Björnson, E, Söderlund, S, Borén, C, Eliasson, B, Pietiläinen, KH, Bogl, LH, Hakkarainen, A, Lundbom, N, Rivellese, A, Riccardi, G, Després, J-P, Alméras, N, Holst, JJ, Deacon, CF, Borén, J & Taskinen, M-R 2016, 'Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men', PLOS ONE, vol. 11, no. 1, e0145890, pp. 1-15. https://doi.org/10.1371/journal.pone.0145890

APA

Matikainen, N., Björnson, E., Söderlund, S., Borén, C., Eliasson, B., Pietiläinen, K. H., ... Taskinen, M-R. (2016). Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men. PLOS ONE, 11(1), 1-15. [e0145890]. https://doi.org/10.1371/journal.pone.0145890

Vancouver

Matikainen N, Björnson E, Söderlund S, Borén C, Eliasson B, Pietiläinen KH et al. Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men. PLOS ONE. 2016;11(1):1-15. e0145890. https://doi.org/10.1371/journal.pone.0145890

Author

Matikainen, Niina ; Björnson, Elias ; Söderlund, Sanni ; Borén, Christofer ; Eliasson, Björn ; Pietiläinen, Kirsi H ; Bogl, Leonie H ; Hakkarainen, Antti ; Lundbom, Nina ; Rivellese, Angela ; Riccardi, Gabriele ; Després, Jean-Pierre ; Alméras, Natalie ; Holst, Jens Juul ; Deacon, Carolyn F ; Borén, Jan ; Taskinen, Marja-Riitta. / Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men. In: PLOS ONE. 2016 ; Vol. 11, No. 1. pp. 1-15.

Bibtex

@article{f4068775cace465cb825cdc935c2c843,
title = "Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men",
abstract = "CONTEXT: Glucose and lipids stimulate the gut-hormones glucagon-like peptide (GLP)-1, GLP-2 and glucose-dependent insulinotropic polypeptide (GIP) but the effect of these on human postprandial lipid metabolism is not fully clarified.OBJECTIVE: To explore the responses of GLP-1, GLP-2 and GIP after a fat-rich meal compared to the same responses after an oral glucose tolerance test (OGTT) and to investigate possible relationships between incretin response and triglyceride-rich lipoprotein (TRL) response to a fat-rich meal.DESIGN: Glucose, insulin, GLP-1, GLP-2 and GIP were measured after an OGTT and after a fat-rich meal in 65 healthy obese (BMI 26.5-40.2 kg/m2) male subjects. Triglycerides (TG), apoB48 and apoB100 in TG-rich lipoproteins (chylomicrons, VLDL1 and VLDL2) were measured after the fat-rich meal.MAIN OUTCOME MEASURES: Postprandial responses (area under the curve, AUC) for glucose, insulin, GLP-1, GLP-2, GIP in plasma, and TG, apoB48 and apoB100 in plasma and TG-rich lipoproteins.RESULTS: The GLP-1, GLP-2 and GIP responses after the fat-rich meal and after the OGTT correlated strongly (r = 0.73, p<0.0001; r = 0.46, p<0.001 and r = 0.69, p<0.001, respectively). Glucose and insulin AUCs were lower, but the AUCs for GLP-1, GLP-2 and GIP were significantly higher after the fat-rich meal than after the OGTT. The peak value for all hormones appeared at 120 minutes after the fat-rich meal, compared to 30 minutes after the OGTT. After the fat-rich meal, the AUCs for GLP-1, GLP-2 and GIP correlated significantly with plasma TG- and apoB48 AUCs but the contribution was very modest.CONCLUSIONS: In obese males, GLP-1, GLP-2 and GIP responses to a fat-rich meal are greater than following an OGTT. However, the most important explanatory variable for postprandial TG excursion was fasting triglycerides. The contribution of endogenous GLP-1, GLP-2 and GIP to explaining the variance in postprandial TG excursion was minor.",
author = "Niina Matikainen and Elias Bj{\"o}rnson and Sanni S{\"o}derlund and Christofer Bor{\'e}n and Bj{\"o}rn Eliasson and Pietil{\"a}inen, {Kirsi H} and Bogl, {Leonie H} and Antti Hakkarainen and Nina Lundbom and Angela Rivellese and Gabriele Riccardi and Jean-Pierre Despr{\'e}s and Natalie Alm{\'e}ras and Holst, {Jens Juul} and Deacon, {Carolyn F} and Jan Bor{\'e}n and Marja-Riitta Taskinen",
year = "2016",
doi = "10.1371/journal.pone.0145890",
language = "English",
volume = "11",
pages = "1--15",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "1",

}

RIS

TY - JOUR

T1 - Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men

AU - Matikainen, Niina

AU - Björnson, Elias

AU - Söderlund, Sanni

AU - Borén, Christofer

AU - Eliasson, Björn

AU - Pietiläinen, Kirsi H

AU - Bogl, Leonie H

AU - Hakkarainen, Antti

AU - Lundbom, Nina

AU - Rivellese, Angela

AU - Riccardi, Gabriele

AU - Després, Jean-Pierre

AU - Alméras, Natalie

AU - Holst, Jens Juul

AU - Deacon, Carolyn F

AU - Borén, Jan

AU - Taskinen, Marja-Riitta

PY - 2016

Y1 - 2016

N2 - CONTEXT: Glucose and lipids stimulate the gut-hormones glucagon-like peptide (GLP)-1, GLP-2 and glucose-dependent insulinotropic polypeptide (GIP) but the effect of these on human postprandial lipid metabolism is not fully clarified.OBJECTIVE: To explore the responses of GLP-1, GLP-2 and GIP after a fat-rich meal compared to the same responses after an oral glucose tolerance test (OGTT) and to investigate possible relationships between incretin response and triglyceride-rich lipoprotein (TRL) response to a fat-rich meal.DESIGN: Glucose, insulin, GLP-1, GLP-2 and GIP were measured after an OGTT and after a fat-rich meal in 65 healthy obese (BMI 26.5-40.2 kg/m2) male subjects. Triglycerides (TG), apoB48 and apoB100 in TG-rich lipoproteins (chylomicrons, VLDL1 and VLDL2) were measured after the fat-rich meal.MAIN OUTCOME MEASURES: Postprandial responses (area under the curve, AUC) for glucose, insulin, GLP-1, GLP-2, GIP in plasma, and TG, apoB48 and apoB100 in plasma and TG-rich lipoproteins.RESULTS: The GLP-1, GLP-2 and GIP responses after the fat-rich meal and after the OGTT correlated strongly (r = 0.73, p<0.0001; r = 0.46, p<0.001 and r = 0.69, p<0.001, respectively). Glucose and insulin AUCs were lower, but the AUCs for GLP-1, GLP-2 and GIP were significantly higher after the fat-rich meal than after the OGTT. The peak value for all hormones appeared at 120 minutes after the fat-rich meal, compared to 30 minutes after the OGTT. After the fat-rich meal, the AUCs for GLP-1, GLP-2 and GIP correlated significantly with plasma TG- and apoB48 AUCs but the contribution was very modest.CONCLUSIONS: In obese males, GLP-1, GLP-2 and GIP responses to a fat-rich meal are greater than following an OGTT. However, the most important explanatory variable for postprandial TG excursion was fasting triglycerides. The contribution of endogenous GLP-1, GLP-2 and GIP to explaining the variance in postprandial TG excursion was minor.

AB - CONTEXT: Glucose and lipids stimulate the gut-hormones glucagon-like peptide (GLP)-1, GLP-2 and glucose-dependent insulinotropic polypeptide (GIP) but the effect of these on human postprandial lipid metabolism is not fully clarified.OBJECTIVE: To explore the responses of GLP-1, GLP-2 and GIP after a fat-rich meal compared to the same responses after an oral glucose tolerance test (OGTT) and to investigate possible relationships between incretin response and triglyceride-rich lipoprotein (TRL) response to a fat-rich meal.DESIGN: Glucose, insulin, GLP-1, GLP-2 and GIP were measured after an OGTT and after a fat-rich meal in 65 healthy obese (BMI 26.5-40.2 kg/m2) male subjects. Triglycerides (TG), apoB48 and apoB100 in TG-rich lipoproteins (chylomicrons, VLDL1 and VLDL2) were measured after the fat-rich meal.MAIN OUTCOME MEASURES: Postprandial responses (area under the curve, AUC) for glucose, insulin, GLP-1, GLP-2, GIP in plasma, and TG, apoB48 and apoB100 in plasma and TG-rich lipoproteins.RESULTS: The GLP-1, GLP-2 and GIP responses after the fat-rich meal and after the OGTT correlated strongly (r = 0.73, p<0.0001; r = 0.46, p<0.001 and r = 0.69, p<0.001, respectively). Glucose and insulin AUCs were lower, but the AUCs for GLP-1, GLP-2 and GIP were significantly higher after the fat-rich meal than after the OGTT. The peak value for all hormones appeared at 120 minutes after the fat-rich meal, compared to 30 minutes after the OGTT. After the fat-rich meal, the AUCs for GLP-1, GLP-2 and GIP correlated significantly with plasma TG- and apoB48 AUCs but the contribution was very modest.CONCLUSIONS: In obese males, GLP-1, GLP-2 and GIP responses to a fat-rich meal are greater than following an OGTT. However, the most important explanatory variable for postprandial TG excursion was fasting triglycerides. The contribution of endogenous GLP-1, GLP-2 and GIP to explaining the variance in postprandial TG excursion was minor.

U2 - 10.1371/journal.pone.0145890

DO - 10.1371/journal.pone.0145890

M3 - Journal article

C2 - 26752550

VL - 11

SP - 1

EP - 15

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 1

M1 - e0145890

ER -

ID: 160445104