Mammalian heme peroxidases: from molecular mechanisms to health implications

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Mammalian heme peroxidases : from molecular mechanisms to health implications. / Davies, Michael Jonathan; Hawkins, Clare Louise; Pattison, David I; Rees, Martin D.

In: Antioxidants & Redox Signaling, Vol. 10, No. 7, 07.2008, p. 1199-234.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Davies, MJ, Hawkins, CL, Pattison, DI & Rees, MD 2008, 'Mammalian heme peroxidases: from molecular mechanisms to health implications', Antioxidants & Redox Signaling, vol. 10, no. 7, pp. 1199-234. https://doi.org/10.1089/ars.2007.1927

APA

Davies, M. J., Hawkins, C. L., Pattison, D. I., & Rees, M. D. (2008). Mammalian heme peroxidases: from molecular mechanisms to health implications. Antioxidants & Redox Signaling, 10(7), 1199-234. https://doi.org/10.1089/ars.2007.1927

Vancouver

Davies MJ, Hawkins CL, Pattison DI, Rees MD. Mammalian heme peroxidases: from molecular mechanisms to health implications. Antioxidants & Redox Signaling. 2008 Jul;10(7):1199-234. https://doi.org/10.1089/ars.2007.1927

Author

Davies, Michael Jonathan ; Hawkins, Clare Louise ; Pattison, David I ; Rees, Martin D. / Mammalian heme peroxidases : from molecular mechanisms to health implications. In: Antioxidants & Redox Signaling. 2008 ; Vol. 10, No. 7. pp. 1199-234.

Bibtex

@article{1163d293efec44b3978ca649edb44e97,
title = "Mammalian heme peroxidases: from molecular mechanisms to health implications",
abstract = "A marked increase in interest has occurred over the last few years in the role that mammalian heme peroxidase enzymes, primarily myeloperoxidase, eosinophil peroxidase, and lactoperoxidase, may play in both disease prevention and human pathologies. This increased interest has been sparked by developments in our understanding of polymorphisms that control the levels of these enzymes, a greater understanding of the basic chemistry and biochemistry of the oxidants formed by these species, the development of specific biomarkers that can be used in vivo to detect damage induced by these oxidants, the detection of active forms of these peroxidases at most, if not all, sites of inflammation, and a correlation between the levels of these enzymes and a number of major human pathologies. This article reviews recent developments in our understanding of the enzymology, chemistry, biochemistry and biologic roles of mammalian peroxidases and the oxidants that they generate, the potential role of these oxidants in human disease, and the use of the levels of these enzymes in disease prognosis.",
keywords = "Animals, Eosinophil Peroxidase, Heme, Humans, Inflammation, Lactoperoxidase, Oxidants, Peroxidase, Peroxidases",
author = "Davies, {Michael Jonathan} and Hawkins, {Clare Louise} and Pattison, {David I} and Rees, {Martin D}",
year = "2008",
month = "7",
doi = "10.1089/ars.2007.1927",
language = "English",
volume = "10",
pages = "1199--234",
journal = "Antioxidants & Redox Signaling",
issn = "1523-0864",
publisher = "Mary AnnLiebert, Inc. Publishers",
number = "7",

}

RIS

TY - JOUR

T1 - Mammalian heme peroxidases

T2 - from molecular mechanisms to health implications

AU - Davies, Michael Jonathan

AU - Hawkins, Clare Louise

AU - Pattison, David I

AU - Rees, Martin D

PY - 2008/7

Y1 - 2008/7

N2 - A marked increase in interest has occurred over the last few years in the role that mammalian heme peroxidase enzymes, primarily myeloperoxidase, eosinophil peroxidase, and lactoperoxidase, may play in both disease prevention and human pathologies. This increased interest has been sparked by developments in our understanding of polymorphisms that control the levels of these enzymes, a greater understanding of the basic chemistry and biochemistry of the oxidants formed by these species, the development of specific biomarkers that can be used in vivo to detect damage induced by these oxidants, the detection of active forms of these peroxidases at most, if not all, sites of inflammation, and a correlation between the levels of these enzymes and a number of major human pathologies. This article reviews recent developments in our understanding of the enzymology, chemistry, biochemistry and biologic roles of mammalian peroxidases and the oxidants that they generate, the potential role of these oxidants in human disease, and the use of the levels of these enzymes in disease prognosis.

AB - A marked increase in interest has occurred over the last few years in the role that mammalian heme peroxidase enzymes, primarily myeloperoxidase, eosinophil peroxidase, and lactoperoxidase, may play in both disease prevention and human pathologies. This increased interest has been sparked by developments in our understanding of polymorphisms that control the levels of these enzymes, a greater understanding of the basic chemistry and biochemistry of the oxidants formed by these species, the development of specific biomarkers that can be used in vivo to detect damage induced by these oxidants, the detection of active forms of these peroxidases at most, if not all, sites of inflammation, and a correlation between the levels of these enzymes and a number of major human pathologies. This article reviews recent developments in our understanding of the enzymology, chemistry, biochemistry and biologic roles of mammalian peroxidases and the oxidants that they generate, the potential role of these oxidants in human disease, and the use of the levels of these enzymes in disease prognosis.

KW - Animals

KW - Eosinophil Peroxidase

KW - Heme

KW - Humans

KW - Inflammation

KW - Lactoperoxidase

KW - Oxidants

KW - Peroxidase

KW - Peroxidases

U2 - 10.1089/ars.2007.1927

DO - 10.1089/ars.2007.1927

M3 - Journal article

C2 - 18331199

VL - 10

SP - 1199

EP - 1234

JO - Antioxidants & Redox Signaling

JF - Antioxidants & Redox Signaling

SN - 1523-0864

IS - 7

ER -

ID: 129670839