Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese : Comparison of type 2 diabetes patients and healthy controls. / Yabe, Daisuke; Kuroe, Akira; Lee, Soushou; Watanabe, Koin; Hyo, Takanori; Hishizawa, Masahiro; Kurose, Takeshi; Deacon, Carolyn F; Holst, Jens Juul; Hirano, Tsutomu; Inagaki, Nobuya; Seino, Yutaka.

In: Journal of Diabetes Investigation, Vol. 1, No. 1-2, 22.04.2010, p. 56-9.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Yabe, D, Kuroe, A, Lee, S, Watanabe, K, Hyo, T, Hishizawa, M, Kurose, T, Deacon, CF, Holst, JJ, Hirano, T, Inagaki, N & Seino, Y 2010, 'Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls', Journal of Diabetes Investigation, vol. 1, no. 1-2, pp. 56-9. https://doi.org/10.1111/j.2040-1124.2010.00010.x

APA

Yabe, D., Kuroe, A., Lee, S., Watanabe, K., Hyo, T., Hishizawa, M., ... Seino, Y. (2010). Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls. Journal of Diabetes Investigation, 1(1-2), 56-9. https://doi.org/10.1111/j.2040-1124.2010.00010.x

Vancouver

Yabe D, Kuroe A, Lee S, Watanabe K, Hyo T, Hishizawa M et al. Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls. Journal of Diabetes Investigation. 2010 Apr 22;1(1-2):56-9. https://doi.org/10.1111/j.2040-1124.2010.00010.x

Author

Yabe, Daisuke ; Kuroe, Akira ; Lee, Soushou ; Watanabe, Koin ; Hyo, Takanori ; Hishizawa, Masahiro ; Kurose, Takeshi ; Deacon, Carolyn F ; Holst, Jens Juul ; Hirano, Tsutomu ; Inagaki, Nobuya ; Seino, Yutaka. / Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese : Comparison of type 2 diabetes patients and healthy controls. In: Journal of Diabetes Investigation. 2010 ; Vol. 1, No. 1-2. pp. 56-9.

Bibtex

@article{1e35982ab1c142b4af5c713fad2338b3,
title = "Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls",
abstract = "Although glucose-dependent insulinotropic polypeptide (GIP) levels have been characterized previously, GLP-1 levels in Asians remain unclear. Here, we investigate total and intact levels of GLP-1, as well as GIP during oral glucose and meal tolerance tests (OGTT and MTT) in Japanese patients with or without type 2 diabetes (T2DM). Seventeen Japanese healthy controls and 18 age-matched and untreated patients with T2DM of short duration participated in the present study. Fasting levels of total GPL-1 were similar between the two groups (approximately 15 pM), and intact GLP-1 levels were considerably low in both groups (less than 1 pM). In both groups, total GLP-1 reached a peak 30 min after glucose ingestion (30-40 pM), whereas intact GLP-1 levels remained low with no significant peak. In MTT, total and intact GLP-1 showed no obvious peak. The current data indicate that intact GLP-1 levels are considerably low in the Japanese and that meal-induced enhancement of GLP-1 secretion is negligible in the Japanese. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2010.00010.x, 2010).",
author = "Daisuke Yabe and Akira Kuroe and Soushou Lee and Koin Watanabe and Takanori Hyo and Masahiro Hishizawa and Takeshi Kurose and Deacon, {Carolyn F} and Holst, {Jens Juul} and Tsutomu Hirano and Nobuya Inagaki and Yutaka Seino",
year = "2010",
month = "4",
day = "22",
doi = "10.1111/j.2040-1124.2010.00010.x",
language = "English",
volume = "1",
pages = "56--9",
journal = "Journal of Diabetes Investigation",
issn = "2040-1116",
publisher = "Wiley-Blackwell Publishing Asia",
number = "1-2",

}

RIS

TY - JOUR

T1 - Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese

T2 - Comparison of type 2 diabetes patients and healthy controls

AU - Yabe, Daisuke

AU - Kuroe, Akira

AU - Lee, Soushou

AU - Watanabe, Koin

AU - Hyo, Takanori

AU - Hishizawa, Masahiro

AU - Kurose, Takeshi

AU - Deacon, Carolyn F

AU - Holst, Jens Juul

AU - Hirano, Tsutomu

AU - Inagaki, Nobuya

AU - Seino, Yutaka

PY - 2010/4/22

Y1 - 2010/4/22

N2 - Although glucose-dependent insulinotropic polypeptide (GIP) levels have been characterized previously, GLP-1 levels in Asians remain unclear. Here, we investigate total and intact levels of GLP-1, as well as GIP during oral glucose and meal tolerance tests (OGTT and MTT) in Japanese patients with or without type 2 diabetes (T2DM). Seventeen Japanese healthy controls and 18 age-matched and untreated patients with T2DM of short duration participated in the present study. Fasting levels of total GPL-1 were similar between the two groups (approximately 15 pM), and intact GLP-1 levels were considerably low in both groups (less than 1 pM). In both groups, total GLP-1 reached a peak 30 min after glucose ingestion (30-40 pM), whereas intact GLP-1 levels remained low with no significant peak. In MTT, total and intact GLP-1 showed no obvious peak. The current data indicate that intact GLP-1 levels are considerably low in the Japanese and that meal-induced enhancement of GLP-1 secretion is negligible in the Japanese. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2010.00010.x, 2010).

AB - Although glucose-dependent insulinotropic polypeptide (GIP) levels have been characterized previously, GLP-1 levels in Asians remain unclear. Here, we investigate total and intact levels of GLP-1, as well as GIP during oral glucose and meal tolerance tests (OGTT and MTT) in Japanese patients with or without type 2 diabetes (T2DM). Seventeen Japanese healthy controls and 18 age-matched and untreated patients with T2DM of short duration participated in the present study. Fasting levels of total GPL-1 were similar between the two groups (approximately 15 pM), and intact GLP-1 levels were considerably low in both groups (less than 1 pM). In both groups, total GLP-1 reached a peak 30 min after glucose ingestion (30-40 pM), whereas intact GLP-1 levels remained low with no significant peak. In MTT, total and intact GLP-1 showed no obvious peak. The current data indicate that intact GLP-1 levels are considerably low in the Japanese and that meal-induced enhancement of GLP-1 secretion is negligible in the Japanese. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2010.00010.x, 2010).

U2 - 10.1111/j.2040-1124.2010.00010.x

DO - 10.1111/j.2040-1124.2010.00010.x

M3 - Journal article

C2 - 24843409

VL - 1

SP - 56

EP - 59

JO - Journal of Diabetes Investigation

JF - Journal of Diabetes Investigation

SN - 2040-1116

IS - 1-2

ER -

ID: 117855159