Liposome accumulation in irradiated tumors display important tumor and dose dependent differences

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Liposome accumulation in irradiated tumors display important tumor and dose dependent differences. / Hansen, Anders Elias; Fliedner, Frederikke Petrine; Henriksen, Jonas Rosager; Jørgensen, Jesper Tranekjær; Clemmensen, Andreas Ettrup; Børresen, Betina; Elema, Dennis Ringkjøbing; Kjær, Andreas; Andresen, Thomas Lars.

In: Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 14, No. 1, 2018, p. 27-34.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hansen, AE, Fliedner, FP, Henriksen, JR, Jørgensen, JT, Clemmensen, AE, Børresen, B, Elema, DR, Kjær, A & Andresen, TL 2018, 'Liposome accumulation in irradiated tumors display important tumor and dose dependent differences', Nanomedicine: Nanotechnology, Biology and Medicine, vol. 14, no. 1, pp. 27-34. https://doi.org/10.1016/j.nano.2017.08.013

APA

Hansen, A. E., Fliedner, F. P., Henriksen, J. R., Jørgensen, J. T., Clemmensen, A. E., Børresen, B., Elema, D. R., Kjær, A., & Andresen, T. L. (2018). Liposome accumulation in irradiated tumors display important tumor and dose dependent differences. Nanomedicine: Nanotechnology, Biology and Medicine, 14(1), 27-34. https://doi.org/10.1016/j.nano.2017.08.013

Vancouver

Hansen AE, Fliedner FP, Henriksen JR, Jørgensen JT, Clemmensen AE, Børresen B et al. Liposome accumulation in irradiated tumors display important tumor and dose dependent differences. Nanomedicine: Nanotechnology, Biology and Medicine. 2018;14(1):27-34. https://doi.org/10.1016/j.nano.2017.08.013

Author

Hansen, Anders Elias ; Fliedner, Frederikke Petrine ; Henriksen, Jonas Rosager ; Jørgensen, Jesper Tranekjær ; Clemmensen, Andreas Ettrup ; Børresen, Betina ; Elema, Dennis Ringkjøbing ; Kjær, Andreas ; Andresen, Thomas Lars. / Liposome accumulation in irradiated tumors display important tumor and dose dependent differences. In: Nanomedicine: Nanotechnology, Biology and Medicine. 2018 ; Vol. 14, No. 1. pp. 27-34.

Bibtex

@article{b920680e81074d21a6a93f4e2827bd53,

title = "Liposome accumulation in irradiated tumors display important tumor and dose dependent differences",

abstract = "Radiation therapy may affect several important parameters in the tumor microenvironment and thereby influence the accumulation of liposomes by the enhanced permeability and retention (EPR)-effect. Here we investigate the effect of single dose radiation therapy on liposome tumor accumulation by PET/CT imaging using radiolabeled liposomes. Head and neck cancer xenografts (FaDu) and syngenic colorectal (CT26) cancer models were investigated. Radiotherapy displayed opposite effects in the two models. FaDu tumors displayed increased mean accumulation of liposomes for radiation doses up to 10 Gy, whereas CT26 tumors displayed a tendency for decreased accumulation. Tumor hypoxia was found negatively correlated to microregional distribution of liposomes. However, liposome distribution in relation to hypoxia was improved at lower radiation doses. The study reveals that the heterogeneity in liposome tumor accumulation between tumors and different radiation protocols are important factors that need to be taken into consideration to achieve optimal effect of liposome based radio-sensitizer therapy.",

keywords = "Animals, Colorectal Neoplasms/diagnostic imaging, Copper Radioisotopes/administration & dosage, Female, Gamma Rays/therapeutic use, Head and Neck Neoplasms/diagnostic imaging, Humans, Hypoxia/metabolism, Liposomes/administration & dosage, Mice, Mice, Nude, Positron Emission Tomography Computed Tomography/methods, Radiation Dosage, Tissue Distribution, Treatment Outcome, Tumor Cells, Cultured, Xenograft Model Antitumor Assays",

author = "Hansen, {Anders Elias} and Fliedner, {Frederikke Petrine} and Henriksen, {Jonas Rosager} and J{\o}rgensen, {Jesper Tranekj{\ae}r} and Clemmensen, {Andreas Ettrup} and Betina B{\o}rresen and Elema, {Dennis Ringkj{\o}bing} and Andreas Kj{\ae}r and Andresen, {Thomas Lars}",

year = "2018",

doi = "10.1016/j.nano.2017.08.013",

language = "English",

volume = "14",

pages = "27--34",

journal = "Nanomedicine: Nanotechnology, Biology and Medicine",

issn = "1549-9634",

publisher = "Elsevier",

number = "1",

}

RIS

TY - JOUR

T1 - Liposome accumulation in irradiated tumors display important tumor and dose dependent differences

AU - Hansen, Anders Elias

AU - Fliedner, Frederikke Petrine

AU - Henriksen, Jonas Rosager

AU - Jørgensen, Jesper Tranekjær

AU - Clemmensen, Andreas Ettrup

AU - Børresen, Betina

AU - Elema, Dennis Ringkjøbing

AU - Kjær, Andreas

AU - Andresen, Thomas Lars

PY - 2018

Y1 - 2018

N2 - Radiation therapy may affect several important parameters in the tumor microenvironment and thereby influence the accumulation of liposomes by the enhanced permeability and retention (EPR)-effect. Here we investigate the effect of single dose radiation therapy on liposome tumor accumulation by PET/CT imaging using radiolabeled liposomes. Head and neck cancer xenografts (FaDu) and syngenic colorectal (CT26) cancer models were investigated. Radiotherapy displayed opposite effects in the two models. FaDu tumors displayed increased mean accumulation of liposomes for radiation doses up to 10 Gy, whereas CT26 tumors displayed a tendency for decreased accumulation. Tumor hypoxia was found negatively correlated to microregional distribution of liposomes. However, liposome distribution in relation to hypoxia was improved at lower radiation doses. The study reveals that the heterogeneity in liposome tumor accumulation between tumors and different radiation protocols are important factors that need to be taken into consideration to achieve optimal effect of liposome based radio-sensitizer therapy.

AB - Radiation therapy may affect several important parameters in the tumor microenvironment and thereby influence the accumulation of liposomes by the enhanced permeability and retention (EPR)-effect. Here we investigate the effect of single dose radiation therapy on liposome tumor accumulation by PET/CT imaging using radiolabeled liposomes. Head and neck cancer xenografts (FaDu) and syngenic colorectal (CT26) cancer models were investigated. Radiotherapy displayed opposite effects in the two models. FaDu tumors displayed increased mean accumulation of liposomes for radiation doses up to 10 Gy, whereas CT26 tumors displayed a tendency for decreased accumulation. Tumor hypoxia was found negatively correlated to microregional distribution of liposomes. However, liposome distribution in relation to hypoxia was improved at lower radiation doses. The study reveals that the heterogeneity in liposome tumor accumulation between tumors and different radiation protocols are important factors that need to be taken into consideration to achieve optimal effect of liposome based radio-sensitizer therapy.

KW - Animals

KW - Colorectal Neoplasms/diagnostic imaging

KW - Copper Radioisotopes/administration & dosage

KW - Female

KW - Gamma Rays/therapeutic use

KW - Head and Neck Neoplasms/diagnostic imaging

KW - Humans

KW - Hypoxia/metabolism

KW - Liposomes/administration & dosage

KW - Mice

KW - Mice, Nude

KW - Positron Emission Tomography Computed Tomography/methods

KW - Radiation Dosage

KW - Tissue Distribution

KW - Treatment Outcome

KW - Tumor Cells, Cultured

KW - Xenograft Model Antitumor Assays

U2 - 10.1016/j.nano.2017.08.013

DO - 10.1016/j.nano.2017.08.013

M3 - Journal article

C2 - 28882674

VL - 14

SP - 27

EP - 34

JO - Nanomedicine: Nanotechnology, Biology and Medicine

JF - Nanomedicine: Nanotechnology, Biology and Medicine

SN - 1549-9634

IS - 1

ER -

ID: 212685786

Department of Biomedical Sciences