Kinetic modeling in PET imaging of hypoxia

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Kinetic modeling in PET imaging of hypoxia. / Li, Fan; Jørgensen, Jesper Tranekjær; Hansen, Anders E; Kjaer, Andreas.

In: American Journal of Nuclear Medicine and Molecular Imaging, Vol. 4, No. 6, 2014, p. 490-506.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Li, F, Jørgensen, JT, Hansen, AE & Kjaer, A 2014, 'Kinetic modeling in PET imaging of hypoxia', American Journal of Nuclear Medicine and Molecular Imaging, vol. 4, no. 6, pp. 490-506. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171837/>

APA

Li, F., Jørgensen, J. T., Hansen, A. E., & Kjaer, A. (2014). Kinetic modeling in PET imaging of hypoxia. American Journal of Nuclear Medicine and Molecular Imaging, 4(6), 490-506. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171837/

Vancouver

Li F, Jørgensen JT, Hansen AE, Kjaer A. Kinetic modeling in PET imaging of hypoxia. American Journal of Nuclear Medicine and Molecular Imaging. 2014;4(6):490-506.

Author

Li, Fan ; Jørgensen, Jesper Tranekjær ; Hansen, Anders E ; Kjaer, Andreas. / Kinetic modeling in PET imaging of hypoxia. In: American Journal of Nuclear Medicine and Molecular Imaging. 2014 ; Vol. 4, No. 6. pp. 490-506.

Bibtex

@article{69eb1f40d67a4737ba79afff862ced51,
title = "Kinetic modeling in PET imaging of hypoxia",
abstract = "Tumor hypoxia is associated with increased therapeutic resistance leading to poor treatment outcome. Therefore the ability to detect and quantify intratumoral oxygenation could play an important role in future individual personalized treatment strategies. Positron Emission Tomography (PET) can be used for non-invasive mapping of tissue oxygenation in vivo and several hypoxia specific PET tracers have been developed. Evaluation of PET data in the clinic is commonly based on visual assessment together with semiquantitative measurements e.g. standard uptake value (SUV). However, dynamic PET contains additional valuable information on the temporal changes in tracer distribution. Kinetic modeling can be used to extract relevant pharmacokinetic parameters of tracer behavior in vivo that reflects relevant physiological processes. In this paper, we review the potential contribution of kinetic analysis for PET imaging of hypoxia.",
author = "Fan Li and J{\o}rgensen, {Jesper Tranekj{\ae}r} and Hansen, {Anders E} and Andreas Kjaer",
year = "2014",
language = "English",
volume = "4",
pages = "490--506",
journal = "American Journal of Nuclear Medicine and Molecular Imaging",
issn = "2160-8407",
publisher = "e-Century Publishing Corporation",
number = "6",

}

RIS

TY - JOUR

T1 - Kinetic modeling in PET imaging of hypoxia

AU - Li, Fan

AU - Jørgensen, Jesper Tranekjær

AU - Hansen, Anders E

AU - Kjaer, Andreas

PY - 2014

Y1 - 2014

N2 - Tumor hypoxia is associated with increased therapeutic resistance leading to poor treatment outcome. Therefore the ability to detect and quantify intratumoral oxygenation could play an important role in future individual personalized treatment strategies. Positron Emission Tomography (PET) can be used for non-invasive mapping of tissue oxygenation in vivo and several hypoxia specific PET tracers have been developed. Evaluation of PET data in the clinic is commonly based on visual assessment together with semiquantitative measurements e.g. standard uptake value (SUV). However, dynamic PET contains additional valuable information on the temporal changes in tracer distribution. Kinetic modeling can be used to extract relevant pharmacokinetic parameters of tracer behavior in vivo that reflects relevant physiological processes. In this paper, we review the potential contribution of kinetic analysis for PET imaging of hypoxia.

AB - Tumor hypoxia is associated with increased therapeutic resistance leading to poor treatment outcome. Therefore the ability to detect and quantify intratumoral oxygenation could play an important role in future individual personalized treatment strategies. Positron Emission Tomography (PET) can be used for non-invasive mapping of tissue oxygenation in vivo and several hypoxia specific PET tracers have been developed. Evaluation of PET data in the clinic is commonly based on visual assessment together with semiquantitative measurements e.g. standard uptake value (SUV). However, dynamic PET contains additional valuable information on the temporal changes in tracer distribution. Kinetic modeling can be used to extract relevant pharmacokinetic parameters of tracer behavior in vivo that reflects relevant physiological processes. In this paper, we review the potential contribution of kinetic analysis for PET imaging of hypoxia.

M3 - Journal article

C2 - 25250200

VL - 4

SP - 490

EP - 506

JO - American Journal of Nuclear Medicine and Molecular Imaging

JF - American Journal of Nuclear Medicine and Molecular Imaging

SN - 2160-8407

IS - 6

ER -

ID: 130806162