KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel.

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KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel. / Lundby, Alicia; Olesen, Søren-Peter.

In: Biochemical and Biophysical Research Communications, Vol. 346, No. 3, 2006, p. 958-67.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lundby, A & Olesen, S-P 2006, 'KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel.', Biochemical and Biophysical Research Communications, vol. 346, no. 3, pp. 958-67. https://doi.org/10.1016/j.bbrc.2006.06.004

APA

Lundby, A., & Olesen, S-P. (2006). KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel. Biochemical and Biophysical Research Communications, 346(3), 958-67. https://doi.org/10.1016/j.bbrc.2006.06.004

Vancouver

Lundby A, Olesen S-P. KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel. Biochemical and Biophysical Research Communications. 2006;346(3):958-67. https://doi.org/10.1016/j.bbrc.2006.06.004

Author

Lundby, Alicia ; Olesen, Søren-Peter. / KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel. In: Biochemical and Biophysical Research Communications. 2006 ; Vol. 346, No. 3. pp. 958-67.

Bibtex

@article{e9ee0820acd711ddb538000ea68e967b,
title = "KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel.",
abstract = "The mammalian Kv4.3 potassium channel is a fast activating and inactivating K+ channel widely distributed in mammalian tissues. Kv4.3 is the major component of various physiologically important currents ranging from A-type currents in the CNS to the transient outward potassium conductance in the heart (I(to)). Here we show that the KCNE3 beta-subunit has a strong inhibitory effect on current conducted by heterologously expressed Kv4.3 channels. KCNE3 reduces the Kv4.3 current amplitude, and it slows down the channel activation and inactivation as well as the recovery from inactivation. KCNE3 also inhibits currents generated by Kv4.3 in complex with the accessory subunit KChIP2. We find the inhibitory effect of KCNE3 to be specific for Kv4.3 within the Kv4 channel family. Kv4.3 has previously been shown to interact with a number of beta-subunits, but none of the described subunit-interactions exert an inhibitory effect on the Kv4.3 current.",
author = "Alicia Lundby and S{\o}ren-Peter Olesen",
note = "Keywords: Animals; Cell Line; Electrophysiology; Female; Gene Expression Regulation; Humans; Ion Channel Gating; Kv Channel-Interacting Proteins; Oocytes; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated; Protein Subunits; RNA; Shal Potassium Channels; Xenopus laevis",
year = "2006",
doi = "10.1016/j.bbrc.2006.06.004",
language = "English",
volume = "346",
pages = "958--67",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel.

AU - Lundby, Alicia

AU - Olesen, Søren-Peter

N1 - Keywords: Animals; Cell Line; Electrophysiology; Female; Gene Expression Regulation; Humans; Ion Channel Gating; Kv Channel-Interacting Proteins; Oocytes; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated; Protein Subunits; RNA; Shal Potassium Channels; Xenopus laevis

PY - 2006

Y1 - 2006

N2 - The mammalian Kv4.3 potassium channel is a fast activating and inactivating K+ channel widely distributed in mammalian tissues. Kv4.3 is the major component of various physiologically important currents ranging from A-type currents in the CNS to the transient outward potassium conductance in the heart (I(to)). Here we show that the KCNE3 beta-subunit has a strong inhibitory effect on current conducted by heterologously expressed Kv4.3 channels. KCNE3 reduces the Kv4.3 current amplitude, and it slows down the channel activation and inactivation as well as the recovery from inactivation. KCNE3 also inhibits currents generated by Kv4.3 in complex with the accessory subunit KChIP2. We find the inhibitory effect of KCNE3 to be specific for Kv4.3 within the Kv4 channel family. Kv4.3 has previously been shown to interact with a number of beta-subunits, but none of the described subunit-interactions exert an inhibitory effect on the Kv4.3 current.

AB - The mammalian Kv4.3 potassium channel is a fast activating and inactivating K+ channel widely distributed in mammalian tissues. Kv4.3 is the major component of various physiologically important currents ranging from A-type currents in the CNS to the transient outward potassium conductance in the heart (I(to)). Here we show that the KCNE3 beta-subunit has a strong inhibitory effect on current conducted by heterologously expressed Kv4.3 channels. KCNE3 reduces the Kv4.3 current amplitude, and it slows down the channel activation and inactivation as well as the recovery from inactivation. KCNE3 also inhibits currents generated by Kv4.3 in complex with the accessory subunit KChIP2. We find the inhibitory effect of KCNE3 to be specific for Kv4.3 within the Kv4 channel family. Kv4.3 has previously been shown to interact with a number of beta-subunits, but none of the described subunit-interactions exert an inhibitory effect on the Kv4.3 current.

U2 - 10.1016/j.bbrc.2006.06.004

DO - 10.1016/j.bbrc.2006.06.004

M3 - Journal article

C2 - 16782062

VL - 346

SP - 958

EP - 967

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 3

ER -

ID: 8466436