Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut: A new antihypertensive concept

Research output: Contribution to journal › Review › peer-review

Standard

Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut : A new antihypertensive concept. / Linz, Benedikt; Saljic, Arnela; Hohl, Mathias; Gawalko, Monika; Jespersen, Thomas; Sanders, Prashanthan; Bohm, Michael; Linz, Dominik.

In: IJC Heart and Vasculature, Vol. 29, 100591, 2020.

Research output: Contribution to journal › Review › peer-review

Harvard

Linz, B, Saljic, A, Hohl, M, Gawalko, M, Jespersen, T, Sanders, P, Bohm, M & Linz, D 2020, 'Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut: A new antihypertensive concept', IJC Heart and Vasculature, vol. 29, 100591. https://doi.org/10.1016/j.ijcha.2020.100591

APA

Linz, B., Saljic, A., Hohl, M., Gawalko, M., Jespersen, T., Sanders, P., Bohm, M., & Linz, D. (2020). Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut: A new antihypertensive concept. IJC Heart and Vasculature, 29, [100591]. https://doi.org/10.1016/j.ijcha.2020.100591

Vancouver

Linz B, Saljic A, Hohl M, Gawalko M, Jespersen T, Sanders P et al. Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut: A new antihypertensive concept. IJC Heart and Vasculature. 2020;29. 100591. https://doi.org/10.1016/j.ijcha.2020.100591

Author

Linz, Benedikt ; Saljic, Arnela ; Hohl, Mathias ; Gawalko, Monika ; Jespersen, Thomas ; Sanders, Prashanthan ; Bohm, Michael ; Linz, Dominik. / Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut : A new antihypertensive concept. In: IJC Heart and Vasculature. 2020 ; Vol. 29.

Bibtex

@article{ad1bde4f8a454b56b4b5c5bf4353fcf7,
title = "Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut: A new antihypertensive concept",
abstract = "Arterial hypertension is one of the main contributors to cardiovascular diseases, including stroke, heart failure, and coronary heart disease. Salt plays a major role in the regulation of blood pressure and is one of the most critical factors for hypertension and stroke. At the individual level, effective salt reduction is difficult to achieve and available methods for managing sodium balance are lacking for many patients. As part of the ingested food, salt is absorbed in the gastrointestinal tract by the sodium proton exchanger subtype 3 (NHE3 also known as Slc9a3), influencing extracellular fluid volume and blood pressure.In this review, we discuss the beneficial effects of pharmacological inhibition of NHE3-mediated sodium absorption in the gut and focus on the effect on blood pressure and end-organ damage. (C) 2020 Published by Elsevier B.V.",
keywords = "Hypertension, Blood pressure, Salt, Sodium-proton-exchanger, Gut, IRRITABLE-BOWEL-SYNDROME, BLOOD-PRESSURE, HUMAN MICROBIOME, NHE3 EXPRESSION, DIETARY-SODIUM, SALT INTAKE, TENAPANOR, KIDNEY, WATER, HYPERTENSION",
author = "Benedikt Linz and Arnela Saljic and Mathias Hohl and Monika Gawalko and Thomas Jespersen and Prashanthan Sanders and Michael Bohm and Dominik Linz",
year = "2020",
doi = "10.1016/j.ijcha.2020.100591",
language = "English",
volume = "29",
journal = "IJC Heart and Vasculature",
issn = "2352-9067",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut

T2 - A new antihypertensive concept

AU - Linz, Benedikt

AU - Saljic, Arnela

AU - Hohl, Mathias

AU - Gawalko, Monika

AU - Jespersen, Thomas

AU - Sanders, Prashanthan

AU - Bohm, Michael

AU - Linz, Dominik

PY - 2020

Y1 - 2020

N2 - Arterial hypertension is one of the main contributors to cardiovascular diseases, including stroke, heart failure, and coronary heart disease. Salt plays a major role in the regulation of blood pressure and is one of the most critical factors for hypertension and stroke. At the individual level, effective salt reduction is difficult to achieve and available methods for managing sodium balance are lacking for many patients. As part of the ingested food, salt is absorbed in the gastrointestinal tract by the sodium proton exchanger subtype 3 (NHE3 also known as Slc9a3), influencing extracellular fluid volume and blood pressure.In this review, we discuss the beneficial effects of pharmacological inhibition of NHE3-mediated sodium absorption in the gut and focus on the effect on blood pressure and end-organ damage. (C) 2020 Published by Elsevier B.V.

AB - Arterial hypertension is one of the main contributors to cardiovascular diseases, including stroke, heart failure, and coronary heart disease. Salt plays a major role in the regulation of blood pressure and is one of the most critical factors for hypertension and stroke. At the individual level, effective salt reduction is difficult to achieve and available methods for managing sodium balance are lacking for many patients. As part of the ingested food, salt is absorbed in the gastrointestinal tract by the sodium proton exchanger subtype 3 (NHE3 also known as Slc9a3), influencing extracellular fluid volume and blood pressure.In this review, we discuss the beneficial effects of pharmacological inhibition of NHE3-mediated sodium absorption in the gut and focus on the effect on blood pressure and end-organ damage. (C) 2020 Published by Elsevier B.V.

KW - Hypertension

KW - Blood pressure

KW - Salt

KW - Sodium-proton-exchanger

KW - Gut

KW - IRRITABLE-BOWEL-SYNDROME

KW - BLOOD-PRESSURE

KW - HUMAN MICROBIOME

KW - NHE3 EXPRESSION

KW - DIETARY-SODIUM

KW - SALT INTAKE

KW - TENAPANOR

KW - KIDNEY

KW - WATER

KW - HYPERTENSION

U2 - 10.1016/j.ijcha.2020.100591

DO - 10.1016/j.ijcha.2020.100591

M3 - Review

C2 - 32760780

VL - 29

JO - IJC Heart and Vasculature

JF - IJC Heart and Vasculature

SN - 2352-9067

M1 - 100591

ER -

ID: 248296761