Increasing gap junctional coupling: a tool for dissecting the role of gap junctions.

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Increasing gap junctional coupling: a tool for dissecting the role of gap junctions. / Axelsen, Lene Nygaard; Haugan, Ketil; Stahlhut, Martin; Kjølbye, Anne-Louise; Hennan, James K; Petersen, Jørgen Søberg; Nielsen, Morten Schak; Holstein-Rathlou, N.-H.

In: Journal of Membrane Biology, Vol. 216, No. 1, 2007, p. 23-35.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Axelsen, LN, Haugan, K, Stahlhut, M, Kjølbye, A-L, Hennan, JK, Petersen, JS, Nielsen, MS & Holstein-Rathlou, N-H 2007, 'Increasing gap junctional coupling: a tool for dissecting the role of gap junctions.', Journal of Membrane Biology, vol. 216, no. 1, pp. 23-35. https://doi.org/10.1007/s00232-007-9026-z

APA

Axelsen, L. N., Haugan, K., Stahlhut, M., Kjølbye, A-L., Hennan, J. K., Petersen, J. S., ... Holstein-Rathlou, N-H. (2007). Increasing gap junctional coupling: a tool for dissecting the role of gap junctions. Journal of Membrane Biology, 216(1), 23-35. https://doi.org/10.1007/s00232-007-9026-z

Vancouver

Axelsen LN, Haugan K, Stahlhut M, Kjølbye A-L, Hennan JK, Petersen JS et al. Increasing gap junctional coupling: a tool for dissecting the role of gap junctions. Journal of Membrane Biology. 2007;216(1):23-35. https://doi.org/10.1007/s00232-007-9026-z

Author

Axelsen, Lene Nygaard ; Haugan, Ketil ; Stahlhut, Martin ; Kjølbye, Anne-Louise ; Hennan, James K ; Petersen, Jørgen Søberg ; Nielsen, Morten Schak ; Holstein-Rathlou, N.-H. / Increasing gap junctional coupling: a tool for dissecting the role of gap junctions. In: Journal of Membrane Biology. 2007 ; Vol. 216, No. 1. pp. 23-35.

Bibtex

@article{bd761190ab5e11ddb5e9000ea68e967b,
title = "Increasing gap junctional coupling: a tool for dissecting the role of gap junctions.",
abstract = "Much of our current knowledge about the physiological and pathophysiological role of gap junctions is based on experiments where coupling has been reduced by either chemical agents or genetic modification. This has brought evidence that gap junctions are important in many physiological processes. In a number of cases, gap junctions have been implicated in the initiation and progress of disease, and experimental uncoupling has been used to investigate the exact role of coupling. The inverse approach, i.e., to increase coupling, has become possible in recent years and represents a new way of testing the role of gap junctions. The aim of this review is to summarize the current knowledge obtained with agents that selectively increase gap junctional intercellular coupling. Two approaches will be reviewed: increasing coupling by the use of antiarrhythmic peptide and its synthetic analogs and by interfering with the gating of gap junctional channels.",
author = "Axelsen, {Lene Nygaard} and Ketil Haugan and Martin Stahlhut and Anne-Louise Kj{\o}lbye and Hennan, {James K} and Petersen, {J{\o}rgen S{\o}berg} and Nielsen, {Morten Schak} and N.-H. Holstein-Rathlou",
note = "Keywords: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Bone and Bones; Cell Communication; Connexin 43; Female; Gap Junctions; Homeostasis; Humans; Ion Channel Gating; Myocardial Ischemia; Oligopeptides; Osteoblasts",
year = "2007",
doi = "10.1007/s00232-007-9026-z",
language = "English",
volume = "216",
pages = "23--35",
journal = "Journal of Membrane Biology",
issn = "0022-2631",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Increasing gap junctional coupling: a tool for dissecting the role of gap junctions.

AU - Axelsen, Lene Nygaard

AU - Haugan, Ketil

AU - Stahlhut, Martin

AU - Kjølbye, Anne-Louise

AU - Hennan, James K

AU - Petersen, Jørgen Søberg

AU - Nielsen, Morten Schak

AU - Holstein-Rathlou, N.-H.

N1 - Keywords: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Bone and Bones; Cell Communication; Connexin 43; Female; Gap Junctions; Homeostasis; Humans; Ion Channel Gating; Myocardial Ischemia; Oligopeptides; Osteoblasts

PY - 2007

Y1 - 2007

N2 - Much of our current knowledge about the physiological and pathophysiological role of gap junctions is based on experiments where coupling has been reduced by either chemical agents or genetic modification. This has brought evidence that gap junctions are important in many physiological processes. In a number of cases, gap junctions have been implicated in the initiation and progress of disease, and experimental uncoupling has been used to investigate the exact role of coupling. The inverse approach, i.e., to increase coupling, has become possible in recent years and represents a new way of testing the role of gap junctions. The aim of this review is to summarize the current knowledge obtained with agents that selectively increase gap junctional intercellular coupling. Two approaches will be reviewed: increasing coupling by the use of antiarrhythmic peptide and its synthetic analogs and by interfering with the gating of gap junctional channels.

AB - Much of our current knowledge about the physiological and pathophysiological role of gap junctions is based on experiments where coupling has been reduced by either chemical agents or genetic modification. This has brought evidence that gap junctions are important in many physiological processes. In a number of cases, gap junctions have been implicated in the initiation and progress of disease, and experimental uncoupling has been used to investigate the exact role of coupling. The inverse approach, i.e., to increase coupling, has become possible in recent years and represents a new way of testing the role of gap junctions. The aim of this review is to summarize the current knowledge obtained with agents that selectively increase gap junctional intercellular coupling. Two approaches will be reviewed: increasing coupling by the use of antiarrhythmic peptide and its synthetic analogs and by interfering with the gating of gap junctional channels.

U2 - 10.1007/s00232-007-9026-z

DO - 10.1007/s00232-007-9026-z

M3 - Journal article

C2 - 17568971

VL - 216

SP - 23

EP - 35

JO - Journal of Membrane Biology

JF - Journal of Membrane Biology

SN - 0022-2631

IS - 1

ER -

ID: 8419811