Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue

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Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue. / Nielsen, Birgitte; Cejvanovic, Vanja; Wortwein, Gitta; Hansen, Allan R.; Marstal, Kasper K.; Weimann, Allan; Bjerring, Peter N.; Dela, Flemming; Poulsen, Henrik E.; Jorgensen, Martin B.

In: Neuroscience Letters, Vol. 690, 2019, p. 1-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, B, Cejvanovic, V, Wortwein, G, Hansen, AR, Marstal, KK, Weimann, A, Bjerring, PN, Dela, F, Poulsen, HE & Jorgensen, MB 2019, 'Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue', Neuroscience Letters, vol. 690, pp. 1-5. https://doi.org/10.1016/j.neulet.2018.09.061

APA

Nielsen, B., Cejvanovic, V., Wortwein, G., Hansen, A. R., Marstal, K. K., Weimann, A., Bjerring, P. N., Dela, F., Poulsen, H. E., & Jorgensen, M. B. (2019). Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue. Neuroscience Letters, 690, 1-5. https://doi.org/10.1016/j.neulet.2018.09.061

Vancouver

Nielsen B, Cejvanovic V, Wortwein G, Hansen AR, Marstal KK, Weimann A et al. Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue. Neuroscience Letters. 2019;690:1-5. https://doi.org/10.1016/j.neulet.2018.09.061

Author

Nielsen, Birgitte ; Cejvanovic, Vanja ; Wortwein, Gitta ; Hansen, Allan R. ; Marstal, Kasper K. ; Weimann, Allan ; Bjerring, Peter N. ; Dela, Flemming ; Poulsen, Henrik E. ; Jorgensen, Martin B. / Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue. In: Neuroscience Letters. 2019 ; Vol. 690. pp. 1-5.

Bibtex

@article{eb57b2b5cdc84e2c869e678f492465da,
title = "Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue",
abstract = "Major depressive disorder (MDD) affects 350 million people worldwide and is a serious socio-economic burden. The most efficient treatment of MDD is electroconvulsive therapy (ECT), which has been shown to influence the oxidative status believed to be part of the pathophysiology of MDD. We investigated the effects of chronic electroconvulsive stimulation (ECS) on mitochondrial respiration and mitochondrial hydrogen peroxide production, RNA oxidation, and the content of mitochondria in the piriform cortex of the rat. We found reductions of mitochondrial respiration in respiratory states 2 and 3 by 33% and 32%, respectively, and a 23% reduction in electron transfer capacity. RNA oxidation, as measured by 8-oxo-7,8-dihydroguanosine, was increased by 58%, while mitochondrial production of H2O2 was unaffected. The increased oxidative stress may thus be ascribed to extra-mitochondrial sources.",
keywords = "Mitochondria, Reactive oxygen species (ROS), Hydrogen peroxide, Major depression, 8-oxoGuo",
author = "Birgitte Nielsen and Vanja Cejvanovic and Gitta Wortwein and Hansen, {Allan R.} and Marstal, {Kasper K.} and Allan Weimann and Bjerring, {Peter N.} and Flemming Dela and Poulsen, {Henrik E.} and Jorgensen, {Martin B.}",
year = "2019",
doi = "10.1016/j.neulet.2018.09.061",
language = "English",
volume = "690",
pages = "1--5",
journal = "Neuroscience letters. Supplement",
issn = "0167-6253",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue

AU - Nielsen, Birgitte

AU - Cejvanovic, Vanja

AU - Wortwein, Gitta

AU - Hansen, Allan R.

AU - Marstal, Kasper K.

AU - Weimann, Allan

AU - Bjerring, Peter N.

AU - Dela, Flemming

AU - Poulsen, Henrik E.

AU - Jorgensen, Martin B.

PY - 2019

Y1 - 2019

N2 - Major depressive disorder (MDD) affects 350 million people worldwide and is a serious socio-economic burden. The most efficient treatment of MDD is electroconvulsive therapy (ECT), which has been shown to influence the oxidative status believed to be part of the pathophysiology of MDD. We investigated the effects of chronic electroconvulsive stimulation (ECS) on mitochondrial respiration and mitochondrial hydrogen peroxide production, RNA oxidation, and the content of mitochondria in the piriform cortex of the rat. We found reductions of mitochondrial respiration in respiratory states 2 and 3 by 33% and 32%, respectively, and a 23% reduction in electron transfer capacity. RNA oxidation, as measured by 8-oxo-7,8-dihydroguanosine, was increased by 58%, while mitochondrial production of H2O2 was unaffected. The increased oxidative stress may thus be ascribed to extra-mitochondrial sources.

AB - Major depressive disorder (MDD) affects 350 million people worldwide and is a serious socio-economic burden. The most efficient treatment of MDD is electroconvulsive therapy (ECT), which has been shown to influence the oxidative status believed to be part of the pathophysiology of MDD. We investigated the effects of chronic electroconvulsive stimulation (ECS) on mitochondrial respiration and mitochondrial hydrogen peroxide production, RNA oxidation, and the content of mitochondria in the piriform cortex of the rat. We found reductions of mitochondrial respiration in respiratory states 2 and 3 by 33% and 32%, respectively, and a 23% reduction in electron transfer capacity. RNA oxidation, as measured by 8-oxo-7,8-dihydroguanosine, was increased by 58%, while mitochondrial production of H2O2 was unaffected. The increased oxidative stress may thus be ascribed to extra-mitochondrial sources.

KW - Mitochondria

KW - Reactive oxygen species (ROS)

KW - Hydrogen peroxide

KW - Major depression

KW - 8-oxoGuo

U2 - 10.1016/j.neulet.2018.09.061

DO - 10.1016/j.neulet.2018.09.061

M3 - Journal article

C2 - 30287304

VL - 690

SP - 1

EP - 5

JO - Neuroscience letters. Supplement

JF - Neuroscience letters. Supplement

SN - 0167-6253

ER -

ID: 230041100