Increase in IL-6, TNF-a, and MMP-9, but not sICAM-1, concentrations depends on exercise duration

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Increase in IL-6, TNF-a, and MMP-9, but not sICAM-1, concentrations depends on exercise duration. / Reihmane, Dace; Jurka, Antra; Tretjakovs, Peteris; Dela, Flemming.

In: European Journal of Applied Physiology, Vol. 113, No. 4, 04.2013, p. 851-8.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Reihmane, D, Jurka, A, Tretjakovs, P & Dela, F 2013, 'Increase in IL-6, TNF-a, and MMP-9, but not sICAM-1, concentrations depends on exercise duration', European Journal of Applied Physiology, vol. 113, no. 4, pp. 851-8. https://doi.org/10.1007/s00421-012-2491-9

APA

Reihmane, D., Jurka, A., Tretjakovs, P., & Dela, F. (2013). Increase in IL-6, TNF-a, and MMP-9, but not sICAM-1, concentrations depends on exercise duration. European Journal of Applied Physiology, 113(4), 851-8. https://doi.org/10.1007/s00421-012-2491-9

Vancouver

Reihmane D, Jurka A, Tretjakovs P, Dela F. Increase in IL-6, TNF-a, and MMP-9, but not sICAM-1, concentrations depends on exercise duration. European Journal of Applied Physiology. 2013 Apr;113(4):851-8. https://doi.org/10.1007/s00421-012-2491-9

Author

Reihmane, Dace ; Jurka, Antra ; Tretjakovs, Peteris ; Dela, Flemming. / Increase in IL-6, TNF-a, and MMP-9, but not sICAM-1, concentrations depends on exercise duration. In: European Journal of Applied Physiology. 2013 ; Vol. 113, No. 4. pp. 851-8.

Bibtex

@article{0b98574233584b20bebc9fd169ec150f,
title = "Increase in IL-6, TNF-a, and MMP-9, but not sICAM-1, concentrations depends on exercise duration",
abstract = "It has been suggested that exercise intensity is of importance in the regulation of increase in pro-inflammatory molecules, but there is still a debate about the effect of duration on these molecules. Therefore, the effect of exercise duration on the serum concentrations of interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), soluble form of intercellular adhesion molecule-1 (sICAM-1), and matrix metalloproteinase-9 (MMP-9) was studied in 22 half-marathon (HM) and 18 marathon (M) male amateur runners who completed their exercise task in 1.8 ± 0.2 (mean ± standard deviation) and 3.6 ± 0.4 h, respectively (thus, average speed was 11.7 ± 1.5 and 11.9 ± 1.8 km h−1, respectively). Blood was sampled 2 days before, 15 min after, and 28 h after the race. IL-6, TNF-α, and MMP-9 always increased immediately after exercise, but the increase was larger (P < 0.05) in M versus HM (∆IL-6: 31 ± 24 vs. 5 ± 4 pg ml−1; ∆TNF-α: 1.7 ± 1.9 vs. 0.5 ± 0.8 pg ml−1; MMP-9: 288 ± 216 vs. 145 ± 128 ng ml−1, respectively). sICAM-1 also increased with exercise, but similarly in M and HM (20 ± 40 vs. 23 ± 32 ng ml−1, respectively). Only sICAM-1 remained elevated 28 h post-exercise in both HM and M, while IL-6, TNF-α, and MMP-9 returned to pre-exercise levels. Competitive HM and M races induce significant increases in IL-6, TNF-α, sICAM-1, and MMP-9 concentrations. As HM and M runners performed the competition with similar absolute intensity, the difference in response between the groups suggests that exercise duration is of importance in the regulation of IL-6, TNF-α, and MMP-9, but not sICAM-1 concentrations in response to prolonged running.",
author = "Dace Reihmane and Antra Jurka and Peteris Tretjakovs and Flemming Dela",
year = "2013",
month = apr,
doi = "10.1007/s00421-012-2491-9",
language = "English",
volume = "113",
pages = "851--8",
journal = "European Journal of Applied Physiology",
issn = "1439-6319",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Increase in IL-6, TNF-a, and MMP-9, but not sICAM-1, concentrations depends on exercise duration

AU - Reihmane, Dace

AU - Jurka, Antra

AU - Tretjakovs, Peteris

AU - Dela, Flemming

PY - 2013/4

Y1 - 2013/4

N2 - It has been suggested that exercise intensity is of importance in the regulation of increase in pro-inflammatory molecules, but there is still a debate about the effect of duration on these molecules. Therefore, the effect of exercise duration on the serum concentrations of interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), soluble form of intercellular adhesion molecule-1 (sICAM-1), and matrix metalloproteinase-9 (MMP-9) was studied in 22 half-marathon (HM) and 18 marathon (M) male amateur runners who completed their exercise task in 1.8 ± 0.2 (mean ± standard deviation) and 3.6 ± 0.4 h, respectively (thus, average speed was 11.7 ± 1.5 and 11.9 ± 1.8 km h−1, respectively). Blood was sampled 2 days before, 15 min after, and 28 h after the race. IL-6, TNF-α, and MMP-9 always increased immediately after exercise, but the increase was larger (P < 0.05) in M versus HM (∆IL-6: 31 ± 24 vs. 5 ± 4 pg ml−1; ∆TNF-α: 1.7 ± 1.9 vs. 0.5 ± 0.8 pg ml−1; MMP-9: 288 ± 216 vs. 145 ± 128 ng ml−1, respectively). sICAM-1 also increased with exercise, but similarly in M and HM (20 ± 40 vs. 23 ± 32 ng ml−1, respectively). Only sICAM-1 remained elevated 28 h post-exercise in both HM and M, while IL-6, TNF-α, and MMP-9 returned to pre-exercise levels. Competitive HM and M races induce significant increases in IL-6, TNF-α, sICAM-1, and MMP-9 concentrations. As HM and M runners performed the competition with similar absolute intensity, the difference in response between the groups suggests that exercise duration is of importance in the regulation of IL-6, TNF-α, and MMP-9, but not sICAM-1 concentrations in response to prolonged running.

AB - It has been suggested that exercise intensity is of importance in the regulation of increase in pro-inflammatory molecules, but there is still a debate about the effect of duration on these molecules. Therefore, the effect of exercise duration on the serum concentrations of interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), soluble form of intercellular adhesion molecule-1 (sICAM-1), and matrix metalloproteinase-9 (MMP-9) was studied in 22 half-marathon (HM) and 18 marathon (M) male amateur runners who completed their exercise task in 1.8 ± 0.2 (mean ± standard deviation) and 3.6 ± 0.4 h, respectively (thus, average speed was 11.7 ± 1.5 and 11.9 ± 1.8 km h−1, respectively). Blood was sampled 2 days before, 15 min after, and 28 h after the race. IL-6, TNF-α, and MMP-9 always increased immediately after exercise, but the increase was larger (P < 0.05) in M versus HM (∆IL-6: 31 ± 24 vs. 5 ± 4 pg ml−1; ∆TNF-α: 1.7 ± 1.9 vs. 0.5 ± 0.8 pg ml−1; MMP-9: 288 ± 216 vs. 145 ± 128 ng ml−1, respectively). sICAM-1 also increased with exercise, but similarly in M and HM (20 ± 40 vs. 23 ± 32 ng ml−1, respectively). Only sICAM-1 remained elevated 28 h post-exercise in both HM and M, while IL-6, TNF-α, and MMP-9 returned to pre-exercise levels. Competitive HM and M races induce significant increases in IL-6, TNF-α, sICAM-1, and MMP-9 concentrations. As HM and M runners performed the competition with similar absolute intensity, the difference in response between the groups suggests that exercise duration is of importance in the regulation of IL-6, TNF-α, and MMP-9, but not sICAM-1 concentrations in response to prolonged running.

U2 - 10.1007/s00421-012-2491-9

DO - 10.1007/s00421-012-2491-9

M3 - Journal article

C2 - 22990627

VL - 113

SP - 851

EP - 858

JO - European Journal of Applied Physiology

JF - European Journal of Applied Physiology

SN - 1439-6319

IS - 4

ER -

ID: 44914770