Immunolymphoscintigraphy for metastatic sentinel nodes: test of a model

Research output: Contribution to journalJournal articleResearchpeer-review

  • B S Nielsen
  • J Madsen
  • J Romer
  • P E G Kristjansen
  • I Buch
  • C Ingvar
  • A Nalla
  • B Hesse
  • A H Chakera
  • Boye S. Nielsen
  • J Madsen
  • John Rømer
  • Paul Ejnar Gremaud Kristjansen
  • I Buch
  • T Binderup
  • C Ingvar
  • Amarnadh Nalla
  • B Hesse
Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune-deficient (nude) mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactively labelled, monoclonal antibody could be scintigraphically visualized, and (2) transportation to and retention in regional lymph nodes of the radioactively labelled antibody after subcutaneous injection in healthy rabbits. Results and Conclusion. Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging.
Original languageEnglish
JournalInternational Journal of Molecular Imaging
Pages (from-to)828151
Number of pages7
Publication statusPublished - 2011

ID: 33790867